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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human NRG1-beta 1/HRG1-beta 1 EGF Domain, CF
catalog :
396-HB-050/CF
quantity :
50 ug
price :
396 USD
more info or order :
citations: 69
Reference
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Zheng X, Salinas K, Velez D, Nakayama T, Lin X, Banerjee D, et al. Host interneurons mediate plasticity reactivated by embryonic inhibitory cell transplantation in mouse visual cortex. Nat Commun. 2021;12:862 pubmed publisher
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Wang J, Wang J, Yang L, Zhao C, Wu L, Xu L, et al. CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair. Nat Commun. 2020;11:4133 pubmed publisher
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Fornasari B, El Soury M, Nato G, Fucini A, Carta G, Ronchi G, et al. Fibroblasts Colonizing Nerve Conduits Express High Levels of Soluble Neuregulin1, a Factor Promoting Schwann Cell Dedifferentiation. Cells. 2020;9: pubmed publisher
Baker M, Abba M, Garcia Mata R, Kazanietz M. P-REX1-Independent, Calcium-Dependent RAC1 Hyperactivation in Prostate Cancer. Cancers (Basel). 2020;12: pubmed publisher
Shu M, Yan H, Xu C, Wu Y, Chi Z, Nian W, et al. A novel anti-HER2 antibody GB235 reverses Trastuzumab resistance in HER2-expressing tumor cells in vitro and in vivo. Sci Rep. 2020;10:2986 pubmed publisher
De S, Campbell C, Venkitaraman A, Esposito A. Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage. Cell Rep. 2020;30:2083-2093.e5 pubmed publisher
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Domínguez S, Rey C, Therreau L, Fanton A, Massotte D, Verret L, et al. Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory. Cell Rep. 2019;29:1099-1112.e4 pubmed publisher
Sato T, Yoo S, Kong R, Sinha A, Chandramani Shivalingappa P, Patel A, et al. Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma. Cancer Res. 2019;79:6084-6100 pubmed publisher
Li J, Zhang Z, Wu G, Yao D, Cui S. Claudin-15 overexpression inhibits proliferation and promotes apoptosis of Schwann cells in vitro. Neural Regen Res. 2020;15:169-177 pubmed publisher
Jalilzad M, Jafari A, Babaei P. Neuregulin1β improves both spatial and associative learning and memory in Alzheimer model of rats possibly through signaling pathways other than Erk1/2. Neuropeptides. 2019;78:101963 pubmed publisher
Meister K, Godse N, Khan N, Hedberg M, Kemp C, Kulkarni S, et al. HER3 targeting potentiates growth suppressive effects of the PI3K inhibitor BYL719 in pre-clinical models of head and neck squamous cell carcinoma. Sci Rep. 2019;9:9130 pubmed publisher
Urbischek M, Rannikmae H, Foets T, Ravn K, Hyvonen M, de la Roche M. Organoid culture media formulated with growth factors of defined cellular activity. Sci Rep. 2019;9:6193 pubmed publisher
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Turowec J, Lau E, Wang X, Brown K, Fellouse F, Jawanda K, et al. Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response. J Biol Chem. 2019;294:1396-1409 pubmed publisher
Surles Zeigler M, Li Y, Distel T, Omotayo H, Ge S, Ford B. Transcriptomic analysis of neuregulin-1 regulated genes following ischemic stroke by computational identification of promoter binding sites: A role for the ETS-1 transcription factor. PLoS ONE. 2018;13:e0197092 pubmed publisher
Oganesyan V, Peng L, Bee J, Li J, Perry S, Comer F, et al. Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody. J Biol Chem. 2018;293:8439-8448 pubmed publisher
Whitehead M, McGonigal R, Willison H, Barnett S. Heparanase attenuates axon degeneration following sciatic nerve transection. Sci Rep. 2018;8:5219 pubmed publisher
Muller K, Schnatz A, Schillner M, Woertge S, Müller C, von Graevenitz I, et al. A predominantly glial origin of axonal ribosomes after nerve injury. Glia. 2018;66:1591-1610 pubmed publisher
Morano M, Ronchi G, Nicolò V, Fornasari B, Crosio A, Perroteau I, et al. Modulation of the Neuregulin 1/ErbB system after skeletal muscle denervation and reinnervation. Sci Rep. 2018;8:5047 pubmed publisher
Capone E, Lamolinara A, D Agostino D, Rossi C, De Laurenzi V, Iezzi M, et al. EV20-mediated delivery of cytotoxic auristatin MMAF exhibits potent therapeutic efficacy in cutaneous melanoma. J Control Release. 2018;277:48-56 pubmed publisher
Matsuoka H, Tanaka H, Sayanagi J, Iwahashi T, Suzuki K, Nishimoto S, et al. Neurotropin® Accelerates the Differentiation of Schwann Cells and Remyelination in a Rat Lysophosphatidylcholine-Induced Demyelination Model. Int J Mol Sci. 2018;19: pubmed publisher
Razavi S, Ghasemi N, Mardani M, Salehi H. Remyelination improvement after neurotrophic factors secreting cells transplantation in rat spinal cord injury. Iran J Basic Med Sci. 2017;20:392-398 pubmed publisher
Uchida H, Machida M, Miura T, Kawasaki T, Okazaki T, Sasaki K, et al. A xenogeneic-free system generating functional human gut organoids from pluripotent stem cells. JCI Insight. 2017;2:e86492 pubmed publisher
Chung D, Wills Z, Fish K, Lewis D. Developmental pruning of excitatory synaptic inputs to parvalbumin interneurons in monkey prefrontal cortex. Proc Natl Acad Sci U S A. 2017;114:E629-E637 pubmed publisher
Fornasari B, El Soury M, De Marchis S, Perroteau I, Geuna S, Gambarotta G. Neuregulin1 alpha activates migration of neuronal progenitors expressing ErbB4. Mol Cell Neurosci. 2016;77:87-94 pubmed publisher
Bogoevska V, Wolters Eisfeld G, Hofmann B, El Gammal A, Mercanoglu B, Gebauer F, et al. HRG/HER2/HER3 signaling promotes AhR-mediated Memo-1 expression and migration in colorectal cancer. Oncogene. 2017;36:2394-2404 pubmed publisher
Unda B, Kwan V, Singh K. Neuregulin-1 Regulates Cortical Inhibitory Neuron Dendrite and Synapse Growth through DISC1. Neural Plast. 2016;2016:7694385 pubmed
Urbanski M, Kingsbury L, Moussouros D, Kassim I, Mehjabeen S, Paknejad N, et al. Myelinating glia differentiation is regulated by extracellular matrix elasticity. Sci Rep. 2016;6:33751 pubmed publisher
Simmons L, Surles Zeigler M, Li Y, Ford G, Newman G, Ford B. Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway. J Neuroinflammation. 2016;13:237 pubmed publisher
Buta C, Benabou E, Lequoy M, Régnault H, Wendum D, Meratbene F, et al. Heregulin-1ß and HER3 in hepatocellular carcinoma: status and regulation by insulin. J Exp Clin Cancer Res. 2016;35:126 pubmed publisher
Huh S, Baek S, Lee K, Whitcomb D, Jo J, Choi S, et al. The reemergence of long-term potentiation in aged Alzheimer's disease mouse model. Sci Rep. 2016;6:29152 pubmed publisher
Wu L, Wang J, Conidi A, Zhao C, Wang H, Ford Z, et al. Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination. Nat Neurosci. 2016;19:1060-72 pubmed publisher
Nakagawa A, Naito A, Sumida T, Nomura S, Shibamoto M, Higo T, et al. Activation of endothelial β-catenin signaling induces heart failure. Sci Rep. 2016;6:25009 pubmed publisher
Li Y, Lein P, Ford G, Liu C, Stovall K, White T, et al. Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury. J Neuroinflammation. 2015;12:64 pubmed publisher
Reuter S, Soonpaa M, Firulli A, Chang A, Field L. Recombinant neuregulin 1 does not activate cardiomyocyte DNA synthesis in normal or infarcted adult mice. PLoS ONE. 2014;9:e115871 pubmed publisher
Lim H, Sharoukhov D, Kassim I, Zhang Y, Salzer J, Melendez Vasquez C. Label-free imaging of Schwann cell myelination by third harmonic generation microscopy. Proc Natl Acad Sci U S A. 2014;111:18025-30 pubmed publisher
Cordo Russo R, Béguelin W, Díaz Flaqué M, Proietti C, Venturutti L, Galigniana N, et al. Targeting ErbB-2 nuclear localization and function inhibits breast cancer growth and overcomes trastuzumab resistance. Oncogene. 2015;34:3413-28 pubmed publisher
Paterson C, Law A. Transient overexposure of neuregulin 3 during early postnatal development impacts selective behaviors in adulthood. PLoS ONE. 2014;9:e104172 pubmed publisher
Kirkegaard T, Yde C, Kveiborg M, Lykkesfeldt A. The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines. Int J Oncol. 2014;45:393-400 pubmed publisher
da Silva T, Eira J, Lopes A, Malheiro A, Sousa V, Luoma A, et al. Peripheral nervous system plasmalogens regulate Schwann cell differentiation and myelination. J Clin Invest. 2014;124:2560-70 pubmed publisher
Forster N, Saladi S, van Bragt M, Sfondouris M, Jones F, Li Z, et al. Basal cell signaling by p63 controls luminal progenitor function and lactation via NRG1. Dev Cell. 2014;28:147-60 pubmed publisher
Mimura K, Shiraishi K, Mueller A, Izawa S, Kua L, So J, et al. The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer. J Immunol. 2013;191:6261-72 pubmed publisher
Fleck D, van Bebber F, Colombo A, Galante C, Schwenk B, Rabe L, et al. Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling. J Neurosci. 2013;33:7856-69 pubmed publisher
Liu R, Lin G, Xu H. An efficient method for dorsal root ganglia neurons purification with a one-time anti-mitotic reagent treatment. PLoS ONE. 2013;8:e60558 pubmed publisher
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Mahar I, Tan S, Davoli M, Dominguez Lopez S, Qiang C, Rachalski A, et al. Subchronic peripheral neuregulin-1 increases ventral hippocampal neurogenesis and induces antidepressant-like effects. PLoS ONE. 2011;6:e26610 pubmed publisher
Sarup J, Jin P, Turin L, Bai X, Beryt M, Brdlik C, et al. Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenografts. Mol Cancer Ther. 2008;7:3223-36 pubmed publisher
Kwon O, Paredes D, Gonzalez C, Neddens J, Hernandez L, Vullhorst D, et al. Neuregulin-1 regulates LTP at CA1 hippocampal synapses through activation of dopamine D4 receptors. Proc Natl Acad Sci U S A. 2008;105:15587-92 pubmed publisher
Hamra F, Chapman K, Nguyen D, Garbers D. Identification of neuregulin as a factor required for formation of aligned spermatogonia. J Biol Chem. 2007;282:721-30 pubmed
Snodgrass Belt P, Gilbert J, Davis F. Central administration of transforming growth factor-alpha and neuregulin-1 suppress active behaviors and cause weight loss in hamsters. Brain Res. 2005;1038:171-82 pubmed
Chakravarti P, Henry M, Quelle F. Prolactin and heregulin override DNA damage-induced growth arrest and promote phosphatidylinositol-3 kinase-dependent proliferation in breast cancer cells. Int J Oncol. 2005;26:509-14 pubmed
Krag T, Bogdanovich S, Jensen C, Fischer M, Hansen Schwartz J, Javazon E, et al. Heregulin ameliorates the dystrophic phenotype in mdx mice. Proc Natl Acad Sci U S A. 2004;101:13856-60 pubmed
Xu Z, Jiang J, Ford G, Ford B. Neuregulin-1 is neuroprotective and attenuates inflammatory responses induced by ischemic stroke. Biochem Biophys Res Commun. 2004;322:440-6 pubmed
image
image 1 :
R&D Systems 396-HB-050/CF image 1
Recombinant Human NRG1-beta 1/HRG1-beta 1 EGF Domain Bioactivity
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
396-HB/CF
SKU :
396-HB-050/CF
product name :
Recombinant Human NRG1-beta 1/HRG1-beta 1 EGF Domain, CF
Description :
The Recombinant Human NRG1-beta 1/HRG1-beta 1 EGF Domain, CF from R&D Systems is derived from E. coli. The Recombinant Human NRG1-beta 1/HRG1-beta 1 EGF Domain, CF has been validated for the following applications: Bioactivity.
target :
Neuregulin-1 beta 1/NRG1 beta 1
category :
Proteins and Enzymes
unit size :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
8 kDa, reducing conditions
theoretical molecular weight :
8 kDa
gene symbol :
NRG1
details of functionality :
Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells. Karey, K.P. et al . (1988) Cancer Research 48 :4083. The ED50 for this effect is 0.06-0.3 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
NP_039250
applications :
Bioactivity
source :
E. coli-derived Recombinant Human NRG1-beta 1/HRG1-beta 1 EGF Domain
USD :
396 USD
alt names :
ARIA, GGF, GGF2, Heregulin-1, HGL, HRG, HRG1, HRG1-alpha, HRG1-beta 1, HRGA, MST131, MSTP131, NDF, neuregulin 1, Neuregulin1, Neuregulin1 beta 1, NRG1, NRG1-IT2, SMDF
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.