product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Thrombomodulin/BDCA-3 Protein, CF
catalog :
3947-PA-010
quantity :
10 ug
price :
396 USD
more info or order :
R&D Systems product webpage
citations: 5
Reference
Bhargavan B, Kanmogne G. SARS-CoV-2 Spike Proteins and Cell-Cell Communication Induce P-Selectin and Markers of Endothelial Injury, NETosis, and Inflammation in Human Lung Microvascular Endothelial Cells and Neutrophils: Implications for the Pathogenesis of COVID-19 Coagulop. Int J Mol Sci. 2023;24: pubmed publisher
Siwiec Kozlik A, Kuszmiersz P, Kasper L, Frolow M, Kozlik Siwiec P, Iwaniec T, et al. Prothrombotic state, endothelial injury, and echocardiographic changes in non-active sarcoidosis patients. Sci Rep. 2022;12:21291 pubmed publisher
Bhargavan B, Kanmogne G. SARS-CoV-2 Spike Proteins and Cell-Cell Communication Inhibits TFPI and Induces Thrombogenic Factors in Human Lung Microvascular Endothelial Cells and Neutrophils: Implications for COVID-19 Coagulopathy Pathogenesis. Int J Mol Sci. 2022;23: pubmed publisher
Hultstr xf6 m M, Fromell K, Larsson A, Persson B, Nilsson B, Quaggin S, et al. Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation-A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients. Biomedicines. 2022;10: pubmed publisher
Daly C, Qian X, Castanaro C, Pasnikowski E, Jiang X, Thomson B, et al. Angiopoietins bind thrombomodulin and inhibit its function as a thrombin cofactor. Sci Rep. 2018;8:505 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
3947-PA
SKU :
3947-PA-010
product name :
Recombinant Human Thrombomodulin/BDCA-3 Protein, CF
Description :
The Recombinant Human Thrombomodulin/BDCA-3 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Thrombomodulin/BDCA-3 Protein, CF has been validated for the following applications: Enzyme Activity.
target :
Thrombomodulin/BDCA-3
category :
Proteins and Enzymes
unit size :
10 ug
buffer :
Supplied as a 0.2 µm filtered solution in Tris and NaCl.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
80-105 kDa, reducing conditions
theoretical molecular weight :
53 kDa
gene symbol :
THBD
details of functionality :
Measured by its ability to mediate thrombin activation of protein C.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P07204
applications :
Enzyme Activity
source :
NS0-derived Recombinant Human Thrombomodulin/BDCA-3 Protein
USD :
396 USD
alt names :
BDCA3, BDCA-3, CD141, CD141 antigen, fetomodulin, THBD, THRM, thrombomodulin, TM
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.