Recombinant Human IGF-I R/IGF1R Protein, CF | R&D Systems 391-GR-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IGF-I R/IGF1R Protein, CF

catalog :

391-GR-050

quantity :

50 ug

price :

480 USD

citations: 10

Reference
Kim D, Kandalaft H, Lowden M, Yang Q, Rossotti M, Robotham A, et al. Sequence tolerance of immunoglobulin variable domain framework regions to noncanonical intradomain disulfide linkages. J Biol Chem. 2023;299:105278 pubmed publisher
Shin J, An S, Kim D, Kim H, Ahn J, Eom J, et al. Grabody B, an IGF1 receptor-based shuttle, mediates efficient delivery of biologics across the blood-brain barrier. Cell Rep Methods. 2022;2:100338 pubmed publisher
Yogi A, Hussack G, van Faassen H, Haqqani A, Delaney C, Brunette E, et al. Brain Delivery of IGF1R5, a Single-Domain Antibody Targeting Insulin-like Growth Factor-1 Receptor. Pharmaceutics. 2022;14: pubmed publisher
Sheff J, Wang P, Xu P, Arbour M, Masson L, van Faassen H, et al. Defining the epitope of a blood-brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor. Sci Rep. 2021;11:4284 pubmed publisher
Yunn N, Park M, Park S, Lee J, Noh J, Shin E, et al. A hotspot for enhancing insulin receptor activation revealed by a conformation-specific allosteric aptamer. Nucleic Acids Res. 2021;49:700-712 pubmed publisher
Solomon V, Alizadeh E, Bernhard W, Makhlouf A, Hartimath S, Hill W, et al. Development and preclinical evaluation of cixutumumab drug conjugates in a model of insulin growth factor receptor I (IGF-1R) positive cancer. Sci Rep. 2020;10:18549 pubmed publisher
Akla B, Broussas M, Loukili N, Robert A, Beau Larvor C, Malissard M, et al. Efficacy of the Antibody-Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid Tumors. Mol Cancer Ther. 2020;19:168-177 pubmed publisher
Cedano Prieto D, Cheng Y, Chang C, Yu J, Takada Y, Takada Y. Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling. PLoS ONE. 2017;12:e0184285 pubmed publisher
Henry K, Sulea T, van Faassen H, Hussack G, Purisima E, Mackenzie C, et al. A Rational Engineering Strategy for Designing Protein A-Binding Camelid Single-Domain Antibodies. PLoS ONE. 2016;11:e0163113 pubmed publisher
Bäck K, Arnqvist H. Changes in insulin and IGF-I receptor expression during differentiation of human preadipocytes. Growth Horm IGF Res. 2009;19:101-11 pubmed publisher

product information

master code :

391-GR

SKU :

391-GR-050

product name :

Recombinant Human IGF-I R/IGF1R Protein, CF

unit size :

50 ug

description :

The Recombinant Human IGF-I R/IGF1R Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IGF-I R/IGF1R Protein, CF has been validated for the following applications: Binding Activity.

target :

IGF-I R/IGF1R

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

160 kDa, 125 kDa, 50 kDa 40 kDa, reducing conditions

theoretical molecular weight :

102.9 kDa (single chain); 81.0 kDa ( alpha chain) 21.9 kDa (▀ chain)

gene symbol :

IGF1R

details of functionality :

Measured by its binding ability in a functional ELISA. Recombinant Human IGF-I R/IGF1R (Catalog # 391-GR) binds to Recombinant Human IGF-I/IGF-1 (Catalog # 291-G1 ).

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P08069

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived human IGF-I R/IGF1R protein Met1-Asn932

source short :

NS0

USD :

480 USD

alt names :

CD221, CD221 antigen, EC 2.7.10, EC 2.7.10.1, IGF1R, IGF-1R, IGF-I receptor, IGFIR, IGF-IR, IGFR, insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor, JTK13, MGC142170, MGC142172, MGC18216, soluble IGF1R variant 1, soluble IGF1R variant 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.