product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IGF-I R/IGF1R Protein, CF
catalog :
391-GR-050
quantity :
50 ug
price :
470 USD
more info or order :
R&D Systems product webpage
citations: 9
Reference
Kim D, Kandalaft H, Lowden M, Yang Q, Rossotti M, Robotham A, et al. Sequence tolerance of immunoglobulin variable domain framework regions to noncanonical intradomain disulfide linkages. J Biol Chem. 2023;299:105278 pubmed publisher
Yogi A, Hussack G, van Faassen H, Haqqani A, Delaney C, Brunette E, et al. Brain Delivery of IGF1R5, a Single-Domain Antibody Targeting Insulin-like Growth Factor-1 Receptor. Pharmaceutics. 2022;14: pubmed publisher
Sheff J, Wang P, Xu P, Arbour M, Masson L, van Faassen H, et al. Defining the epitope of a blood-brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor. Sci Rep. 2021;11:4284 pubmed publisher
Yunn N, Park M, Park S, Lee J, Noh J, Shin E, et al. A hotspot for enhancing insulin receptor activation revealed by a conformation-specific allosteric aptamer. Nucleic Acids Res. 2021;49:700-712 pubmed publisher
Solomon V, Alizadeh E, Bernhard W, Makhlouf A, Hartimath S, Hill W, et al. Development and preclinical evaluation of cixutumumab drug conjugates in a model of insulin growth factor receptor I (IGF-1R) positive cancer. Sci Rep. 2020;10:18549 pubmed publisher
Akla B, Broussas M, Loukili N, Robert A, Beau Larvor C, Malissard M, et al. Efficacy of the Antibody-Drug Conjugate W0101 in Preclinical Models of IGF-1 Receptor Overexpressing Solid Tumors. Mol Cancer Ther. 2020;19:168-177 pubmed publisher
Cedano Prieto D, Cheng Y, Chang C, Yu J, Takada Y, Takada Y. Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling. PLoS ONE. 2017;12:e0184285 pubmed publisher
Henry K, Sulea T, van Faassen H, Hussack G, Purisima E, Mackenzie C, et al. A Rational Engineering Strategy for Designing Protein A-Binding Camelid Single-Domain Antibodies. PLoS ONE. 2016;11:e0163113 pubmed publisher
Bäck K, Arnqvist H. Changes in insulin and IGF-I receptor expression during differentiation of human preadipocytes. Growth Horm IGF Res. 2009;19:101-11 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
391-GR
SKU :
391-GR-050
product name :
Recombinant Human IGF-I R/IGF1R Protein, CF
Description :
The Recombinant Human IGF-I R/IGF1R Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IGF-I R/IGF1R Protein, CF has been validated for the following applications: Binding Activity.
target :
IGF-I R/IGF1R
category :
Proteins and Enzymes
unit size :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
160 kDa, 125 kDa, 50 kDa 40 kDa, reducing conditions
theoretical molecular weight :
102.9 kDa (single chain); 81.0 kDa ( alpha chain) 21.9 kDa ( beta chain)
gene symbol :
IGF1R
details of functionality :
Measured by its binding ability in a functional ELISA. Recombinant Human IGF-I R/IGF1R (Catalog # 391-GR) binds to Recombinant Human IGF-I/IGF-1 (Catalog # 291-G1 ).
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P08069
applications :
Binding Activity
source :
NS0-derived Recombinant Human IGF-I R/IGF1R Protein
USD :
470 USD
alt names :
CD221, CD221 antigen, EC 2.7.10, EC 2.7.10.1, IGF1R, IGF-1R, IGF-I receptor, IGFIR, IGF-IR, IGFR, insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor, JTK13, MGC142170, MGC142172, MGC18216, soluble IGF1R variant 1, soluble IGF1R variant 2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.