Recombinant Human Leptin R Fc Chimera Protein | R&D Systems 389-LR-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Leptin R Fc Chimera Protein

catalog :

389-LR-100

quantity :

100 ug

price :

456 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Masloh S, Chevrel A, Culot M, Perrocheau A, Kalia Y, Frehel S, et al. Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model. Pharmaceutics. 2024;16: pubmed publisher
Yuan D, Yi X, Zhao Y, Poon C, Bullock K, Hansen K, et al. Intranasal delivery of N-terminal modified leptin-pluronic conjugate for treatment of obesity. J Control Release. 2017;263:172-184 pubmed publisher
Mistrik P, Moreau F, Allen J. BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometry. Anal Biochem. 2004;327:271-7 pubmed
Arap W, Kolonin M, Trepel M, Lahdenranta J, Cardo Vila M, Giordano R, et al. Steps toward mapping the human vasculature by phage display. Nat Med. 2002;8:121-7 pubmed

product information

master code :

389-LR

SKU :

389-LR-100

product name :

Recombinant Human Leptin R Fc Chimera Protein

unit size :

100 ug

description :

The Recombinant Human Leptin R Fc Chimera Protein from R&D Systems is derived from NS0. The Recombinant Human Leptin R Fc Chimera Protein has been validated for the following applications: Bioactivity.

target :

Leptin R

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in MES, NaCl and CHAPS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

155-175 kDa, under reducing conditions.

theoretical molecular weight :

121 kDa (monomer)

gene symbol :

LEPR

details of functionality :

Measured by its ability to inhibit Leptin-dependent proliferation of BaF3 mouse pro-B cells transfected with human Leptin R. The ED50 for this effect is 0.02-0.12 ╡g/mL in the presence of 3 ng/mL Recombinant Human Leptin/OB (Catalog # 398-LP ) .

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P48357.2

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human Leptin R protein Human Leptin R (Thr20-Asp839) Accession # P48357.2 IIEGRDMD Human IgG1 (Pro100-Lys330) 6-His tag N-terminus C-terminus

source short :

NS0

USD :

456 USD

alt names :

B219, CD295, CD295 antigen, DB, DKFZp686B1731, huB219, LEPR, LEP-R, leptin receptor, LeptinR, OB R, OB receptor, OB-R, OBRCD295

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage