Recombinant Human Proprotein Convertase 9/PCSK9 Protein, CF | R&D Systems 3888-SE-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Proprotein Convertase 9/PCSK9 Protein, CF

catalog :

3888-SE-010

quantity :

10 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 2

Reference
Fowler A, Van Rompay K, Sampson M, Leo J, Watanabe J, Usachenko J, et al. A Virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in Non-Human Primates. bioRxiv. 2023;: pubmed publisher
Rashid S, Tavori H, Brown P, Linton M, He J, Giunzioni I, et al. Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms. Circulation. 2014;130:431-41 pubmed publisher

image

image 1 :

Recombinant Human Proprotein Convertase 9/PCSK9 Protein Binding Activity

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

3888-SE

SKU :

3888-SE-010

product name :

Recombinant Human Proprotein Convertase 9/PCSK9 Protein, CF

Description :

The Recombinant Human Proprotein Convertase 9/PCSK9 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Proprotein Convertase 9/PCSK9 Protein, CF has been validated for the following applications: Bioactivity.

target :

Proprotein Convertase 9/PCSK9

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in Tris, NaCl and Glycerol.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

19 kDa 66 kDa, reducing conditions

theoretical molecular weight :

14 kDa 59 kDa

gene symbol :

PCSK9

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human LDL R (Catalog # 2148-LD ) is coated at 2 µg/mL, Recombinant Human Proprotein Convertase 9/PCSK9 binds with an ED50 of 70-420 ng/mL.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q8NBP7

applications :

Bioactivity

source :

NS0-derived Recombinant Human Proprotein Convertase 9/PCSK9 Protein

USD :

423 USD

alt names :

EC 3.4.21, EC 3.4.21.111, FH3, FH3neural apoptosis regulated convertase 1, FHCL3, HCHOLA3, hypercholesterolemia, autosomal dominant 3, LDLCQ1, NARC1, NARC-1, NARC-1convertase subtilisin/kexin type 9 preproprotein, NARC1EC 3.4.21.-, Neural apoptosis-regulated convertase 1, PC9, PCSK9, Proprotein convertase 9, proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.

more info or order :

R&D Systems product webpage