Recombinant Human Neuropilin-1 Protein, CF | R&D Systems 3870-N1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Neuropilin-1 Protein, CF

catalog :

3870-N1

quantity :

25 ug

price :

349 USD

citations: 8

Reference
Martinez Martin N, Marcandalli J, Huang C, Arthur C, Perotti M, Foglierini M, et al. An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor. Cell. 2018;174:1158-1171.e19 pubmed publisher
Podojil J, Chiang M, Ifergan I, Copeland R, Liu L, Maloveste S, et al. B7-H4 Modulates Regulatory CD4+ T Cell Induction and Function via Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex. J Immunol. 2018;201:897-907 pubmed publisher
Kerros C, Tripathi S, Zha D, Mehrens J, Sergeeva A, Philips A, et al. Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells. J Biol Chem. 2017;292:10295-10305 pubmed publisher
Teran M, Nugent M. Synergistic Binding of Vascular Endothelial Growth Factor-A and Its Receptors to Heparin Selectively Modulates Complex Affinity. J Biol Chem. 2015;290:16451-62 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Uniewicz K, Cross M, Fernig D. Exogenous recombinant dimeric neuropilin-1 is sufficient to drive angiogenesis. J Biol Chem. 2011;286:12-23 pubmed publisher
Narazaki M, Segarra M, Hou X, Tanaka T, Li X, Tosato G. Oligo-guanosine nucleotide induces neuropilin-1 internalization in endothelial cells and inhibits angiogenesis. Blood. 2010;116:3099-107 pubmed publisher
Jaalouk D, Ozawa M, Sun J, Lahdenranta J, Schlingemann R, Pasqualini R, et al. The original Pathologische Anatomie Leiden-Endothelium monoclonal antibody recognizes a vascular endothelial growth factor binding site within neuropilin-1. Cancer Res. 2007;67:9623-9 pubmed

product information

brand :

R&D Systems

master code :

3870-N1

SKU :

3870-N1-025

product name :

Recombinant Human Neuropilin-1 Protein, CF

description :

The Recombinant Human Neuropilin-1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Neuropilin-1 Protein, CF has been validated for the following applications: Binding Activity.

target :

Neuropilin-1

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

85-95 kDa, reducing conditions

theoretical molecular weight :

70.6 kDa

gene symbol :

NRP1

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Neuropilin-1 can bind recombinant human VEGF165 with an apparent Kd 1 nM.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

catalog number base :

3870-N1

accessionNumbers :

NP_001019799

applications :

Binding Activity

source :

Mouse myeloma cell line, NS0-derived human Neuropilin-1 protein Phe22-Lys644, with a C-terminal 6-His tag

extended description :

His-tag

2020 USD :

349

2021 USD :

349 USD

product details :

His-tag

alt names :

BDCA4, BDCA-4, CD304, CD304 antigen, DKFZp686A03134, DKFZp781F1414, neuropilin 1, neuropilin-1, Neuropilin1, NP1, NRP, NRP1, transmembrane receptor, Vascular endothelial cell growth factor 165 receptor, VEGF165R

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.