product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Neuropilin-1 Protein, CF
catalog :
3870-N1-025
quantity :
25 ug
price :
434 USD
more info or order :
R&D Systems product webpage
citations: 14
Reference
Lu L, Wang L, Zhao L, Liao J, Zhao C, Xu X, et al. A Novel Blood-Brain Barrier-Penetrating and Vascular-Targeting Chimeric Peptide Inhibits Glioma Angiogenesis. Int J Mol Sci. 2023;24: pubmed publisher
Lopera F, Marino C, Chandrahas A, O Hare M, Villalba Moreno N, Aguillon D, et al. Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous man. Nat Med. 2023;29:1243-1252 pubmed publisher
De Vlaeminck Y, Bonelli S, Awad R, Dewilde M, Rizzolio S, Lecocq Q, et al. Targeting Neuropilin-1 with Nanobodies Reduces Colorectal Carcinoma Development. Cancers (Basel). 2020;12: pubmed publisher
Lu L, Chen H, Wang L, Zhao L, Cheng Y, Wang A, et al. A Dual Receptor Targeting- and BBB Penetrating- Peptide Functionalized Polyethyleneimine Nanocomplex for Secretory Endostatin Gene Delivery to Malignant Glioma. Int J Nanomedicine. 2020;15:8875-8892 pubmed publisher
Matilla L, Arrieta V, Jover E, García Peña A, Martínez Martínez E, Sadaba R, et al. Soluble St2 Induces Cardiac Fibroblast Activation and Collagen Synthesis via Neuropilin-1. Cells. 2020;9: pubmed publisher
Martinez Martin N, Marcandalli J, Huang C, Arthur C, Perotti M, Foglierini M, et al. An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor. Cell. 2018;174:1158-1171.e19 pubmed publisher
Podojil J, Chiang M, Ifergan I, Copeland R, Liu L, Maloveste S, et al. B7-H4 Modulates Regulatory CD4+ T Cell Induction and Function via Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex. J Immunol. 2018;201:897-907 pubmed publisher
Kerros C, Tripathi S, Zha D, Mehrens J, Sergeeva A, Philips A, et al. Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells. J Biol Chem. 2017;292:10295-10305 pubmed publisher
Teran M, Nugent M. Synergistic Binding of Vascular Endothelial Growth Factor-A and Its Receptors to Heparin Selectively Modulates Complex Affinity. J Biol Chem. 2015;290:16451-62 pubmed publisher
Harris N, Davydova N, Roufail S, Paquet Fifield S, Paavonen K, Karnezis T, et al. The propeptides of VEGF-D determine heparin binding, receptor heterodimerization, and effects on tumor biology. J Biol Chem. 2013;288:8176-86 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Uniewicz K, Cross M, Fernig D. Exogenous recombinant dimeric neuropilin-1 is sufficient to drive angiogenesis. J Biol Chem. 2011;286:12-23 pubmed publisher
Narazaki M, Segarra M, Hou X, Tanaka T, Li X, Tosato G. Oligo-guanosine nucleotide induces neuropilin-1 internalization in endothelial cells and inhibits angiogenesis. Blood. 2010;116:3099-107 pubmed publisher
Jaalouk D, Ozawa M, Sun J, Lahdenranta J, Schlingemann R, Pasqualini R, et al. The original Pathologische Anatomie Leiden-Endothelium monoclonal antibody recognizes a vascular endothelial growth factor binding site within neuropilin-1. Cancer Res. 2007;67:9623-9 pubmed
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
3870-N1
SKU :
3870-N1-025
product name :
Recombinant Human Neuropilin-1 Protein, CF
Description :
The Recombinant Human Neuropilin-1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Neuropilin-1 Protein, CF has been validated for the following applications: Binding Activity.
target :
Neuropilin-1
category :
Proteins and Enzymes
unit size :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
85-95 kDa, reducing conditions
theoretical molecular weight :
70.6 kDa
gene symbol :
NRP1
details of functionality :
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Neuropilin-1 can bind recombinant human VEGF165 with an apparent Kd 1 nM.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
NP_001019799
applications :
Binding Activity
source :
NS0-derived Recombinant Human Neuropilin-1 Protein
extended description :
His-tag
USD :
434 USD
product details :
His-tag
alt names :
BDCA4, BDCA-4, CD304, CD304 antigen, DKFZp686A03134, DKFZp781F1414, neuropilin 1, neuropilin-1, Neuropilin1, NP1, NRP, NRP1, transmembrane receptor, Vascular endothelial cell growth factor 165 receptor, VEGF165R
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.