Recombinant Human Integrin alpha L beta 2 Protein, CF | R&D Systems 3868-AV product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Integrin alpha L beta 2 Protein, CF

catalog :

3868-AV

quantity :

50 ug

price :

439 USD

citations: 3

Reference
Skoog E, Morikis V, Martin M, Foster G, Cai L, Hansen L, et al. CagY-Dependent Regulation of Type IV Secretion in Helicobacter pylori Is Associated with Alterations in Integrin Binding. MBio. 2018;9: pubmed publisher
Chakraborty S, Nunez D, Hu S, Domingo M, Pardo J, Karmenyan A, et al. FRET based quantification and screening technology platform for the interactions of leukocyte function-associated antigen-1 (LFA-1) with intercellular adhesion molecule-1 (ICAM-1). PLoS ONE. 2014;9:e102572 pubmed publisher
Arthos J, Cicala C, Martinelli E, Macleod K, Van Ryk D, Wei D, et al. HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells. Nat Immunol. 2008;9:301-9 pubmed publisher

product information

brand :

R&D Systems

master code :

3868-AV

SKU :

3868-AV-050

product name :

Recombinant Human Integrin alpha L beta 2 Protein, CF

description :

The Recombinant Human Integrin alpha L beta 2 Protein, CF from R&D Systems is derived from CHO. The Recombinant Human Integrin alpha L beta 2 Protein, CF has been validated for the following applications: Bioactivity.

target :

Integrin alpha L beta 2

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

160 kDa and 100 kDa, reducing conditions

theoretical molecular weight :

121.7 kDa (Integrin alpha L), 79 kDa (Integrin beta 2)

gene symbol :

ITGAL

details of functionality :

Measured by the ability of the immobilized protein to support the adhesion of CHO Chinese hamster ovary cells transfected with ICAM-1. When 5 x 104 cells/well are added to Integrin alpha L beta 2-coated plates (5 µg/mL, 100 µL/well), 60-80% of the cells will adhere after 1 hour at 37° C in the presence of 1 mM MnCl2.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

3868-AV

accessionNumbers :

P20701 (Integrin alpha L) P05107 (Integrin beta 2)

applications :

Bioactivity

source :

Chinese Hamster Ovary cell line, CHO-derived human Integrin alpha L beta 2 protein Human Integrin alpha L (Tyr26-Met1089) Accession # P20701 acidic tail Human Integrin beta 2 (Gln23-Asn700) Accession # P05107 basic tail N-terminus C-terminus

2020 USD :

409

2021 USD :

439 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.