This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human PDGF R beta Fc Chimera Protein
catalog :
385-PR
quantity :
100 ug
price :
369 USD
citations: 10
Reference
Mamer S, Chen S, Weddell J, Palasz A, Wittenkeller A, Kumar M, et al. Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics. Sci Rep. 2017;7:16439 pubmed publisher
Tao Z, Yang H, Shi Q, Fan Q, Wan L, Lu X. Targeted Delivery to Tumor-associated Pericytes via an Affibody with High Affinity for PDGFRβ Enhances the in vivo Antitumor Effects of Human TRAIL. Theranostics. 2017;7:2261-2276 pubmed publisher
Stegmann C, Hochdorfer D, Lieber D, Subramanian N, Stöhr D, Laib Sampaio K, et al. A derivative of platelet-derived growth factor receptor alpha binds to the trimer of human cytomegalovirus and inhibits entry into fibroblasts and endothelial cells. PLoS Pathog. 2017;13:e1006273 pubmed publisher
Wu Y, Prager A, Boos S, Resch M, Brizic I, Mach M, et al. Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry. PLoS Pathog. 2017;13:e1006281 pubmed publisher
Lykkemark S, Mandrup O, Jensen M, Just J, Kristensen P. A novel excision selection method for isolation of antibodies binding antigens expressed specifically by rare cells in tissue sections. Nucleic Acids Res. 2017;45:e107 pubmed publisher
Ding K, Eaton L, Bowley D, Rieser M, Chang Q, Harris M, et al. Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degeneration. MAbs. 2017;9:269-284 pubmed publisher
Donica C, Cui Y, Shi S, Gutstein H. Platelet-derived growth factor receptor-β antagonism restores morphine analgesic potency against neuropathic pain. PLoS ONE. 2014;9:e97105 pubmed publisher
Camorani S, Esposito C, Rienzo A, Catuogno S, Iaboni M, Condorelli G, et al. Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFR? aptamer. Mol Ther. 2014;22:828-41 pubmed publisher
Pfister C, Pfrommer H, Tatagiba M, Roser F. Vascular endothelial growth factor signals through platelet-derived growth factor receptor ? in meningiomas in vitro. Br J Cancer. 2012;107:1702-13 pubmed publisher
Lacoste E, Martineau I, Gagnon G. Platelet concentrates: effects of calcium and thrombin on endothelial cell proliferation and growth factor release. J Periodontol. 2003;74:1498-507 pubmed
product information
brand :
R&D Systems
master code :
385-PR
SKU :
385-PR-100
product name :
Recombinant Human PDGF R beta Fc Chimera Protein
description :
The Recombinant Human PDGF R beta Fc Chimera Protein from R&D Systems is derived from NS0. The Recombinant Human PDGF R beta Fc Chimera Protein has been validated for the following applications: Bioactivity.
target :
PDGF R beta
category :
Proteins and Enzymes
unit size :
100 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
94-124 kDa, reducing conditions
theoretical molecular weight :
84 kDa (monomer)
gene symbol :
PDGFRB
details of functionality :
Measured by its ability to inhibit the biological activity of PDGF-BB using NR6R-3T3 mouse fibroblast cells. Raines, E.W. et al . (1985) Methods Enzymol. 109 :749. The ED50 for this effect is 1-3 µg/mL in the presence of 50 ng/mL Recombinant Human PDGF-BB (Catalog # 220-BB ) .
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
catalog number base :
385-PR
accessionNumbers :
P09619
applications :
Bioactivity
source :
Mouse myeloma cell line, NS0-derived human PDGF R beta protein Human PDGF R beta Leu33-Phe530 (Glu241Asp) Accession # P09619 ENIEGRMD Human IgG1 (Pro100-Lys330) 6-His tag N-terminus C-terminus
2020 USD :
369
2021 USD :
369 USD
alt names :
beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, CD140b, CD140b antigen, EC 2.7.10, EC 2.7.10.1, JTK12, PDGFR, PDGFR1, PDGFRB, PDGF-R-beta, platelet-derived growth factor receptor, beta polypeptide
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.