Recombinant Human Complement Factor H-related 5/CFHR5, CF | R&D Systems 3845-F5-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Complement Factor H-related 5/CFHR5, CF

catalog :

3845-F5-050

quantity :

50 ug

price :

514 USD

citations: 7

Reference
Jeon C, Kim D, Kim K, Lee S, Lee J, Kim S, et al. Complement factor H-related protein 5 alleviates joint inflammation and osteoclast differentiation by disrupting RANK-JNK signaling in collagen antibody-induced arthritis mouse model. Cytokine. 2024;184:156790 pubmed publisher
Zouache M, Richards B, Pappas C, Anstadt R, Liu J, Corsetti T, et al. Levels of complement factor H-related 4 protein do not influence susceptibility to age-related macular degeneration or its course of progression. Nat Commun. 2024;15:443 pubmed publisher
Iglesias M, Sanchez Rivera L, Ibrahim Kosta M, Naudin C, Munsch G, Goumidi L, et al. Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism. Nat Commun. 2023;14:3280 pubmed publisher
Guo W, Sun L, Dong H, Wang G, Xu X, Zhao Z, et al. Glomerular Complement Factor H-Related Protein 5 is Associated with Histologic Injury in Immunoglobulin A Nephropathy. Kidney Int Rep. 2021;6:404-413 pubmed publisher
Medjeral Thomas N, Moffitt H, Lomax Browne H, Constantinou N, Cairns T, Cook H, et al. Glomerular Complement Factor H-Related Protein 5 (FHR5) Is Highly Prevalent in C3 Glomerulopathy and Associated With Renal Impairment. Kidney Int Rep. 2019;4:1387-1400 pubmed publisher
Csincsi A, Szabó Z, Bánlaki Z, Uzonyi B, Cserhalmi M, Kárpáti E, et al. FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation. J Immunol. 2017;199:292-303 pubmed publisher
Csincsi Ã, Kopp A, ZÃ¶ldi M, BÃ¡nlaki Z, Uzonyi B, Hebecker M, et al. Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation. J Immunol. 2015;194:4963-73 pubmed publisher

product information

master code :

3845-F5

SKU :

3845-F5-050

product name :

Recombinant Human Complement Factor H-related 5/CFHR5, CF

unit size :

50 ug

description :

The Recombinant Human Complement Factor H-related 5/CFHR5, CF from R&D Systems is derived from NS0. The Recombinant Human Complement Factor H-related 5/CFHR5, CF has been validated for the following applications: Binding Activity.

target :

Complement Factor H-related 5/CFHR5

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris and NaCl.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

73 kDa, reducing conditions

theoretical molecular weight :

64 kDa

gene symbol :

CFHR5

details of functionality :

Measured by its ability to inhibit the binding of biotinylated Recombinant Human Complement Factor H-related 5/CFHR5 to immobilized Recombinant Human C-Reactive Protein/CRP (Catalog # 1707-CR ). McRae, J.L. et al . (2005) J. Immunol. 174 :6250.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

NP_110414

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived human Complement Factor H-related 5/CFHR5 protein Glu19-Glu569, with a C-terminal 10-His tag

source short :

NS0

USD :

514 USD

alt names :

CFHL5, CFHL5factor H-related protein 5, CFHR5, complement factor H-related 5, Complement Factor Hrelated 5, FHR5, FHR-5complement factor H-related protein 5, FHR5MGC133240, FLJ10549

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.