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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human NRG1-beta 1/HRG1-beta 1 ECD Protein
catalog :
377-HB-050
quantity :
50 ug
price :
377 USD
more info or order :
citations: 14
Reference
Della Flora Nunes G, Wilson E, Hurley E, He B, O Malley B, Poitelon Y, et al. Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination. elife. 2021;10: pubmed publisher
Osada T, Hartman Z, Wei J, Lei G, Hobeika A, Gwin W, et al. Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers. Breast Cancer Res. 2018;20:90 pubmed publisher
Scapin G, Dandey V, Zhang Z, Prosise W, Hruza A, Kelly T, et al. Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature. 2018;556:122-125 pubmed publisher
Palomo Guerrero M, Cosgaya J, Gella A, Casals N, Grijota Martinez C. Uridine-5'-Triphosphate Partially Blocks Differentiation Signals and Favors a more Repair State in Cultured rat Schwann Cells. Neuroscience. 2018;372:255-265 pubmed publisher
Gu J, Yang J, Chang Q, Liu Z, Ghayur T, Gu J. Identification of Anti-EGFR and Anti-ErbB3 Dual Variable Domains Immunoglobulin (DVD-Ig) Proteins with Unique Activities. PLoS ONE. 2015;10:e0124135 pubmed publisher
Gericota B, Anderson J, Mitchell G, Borjesson D, Sturges B, Nolta J, et al. Canine epidermal neural crest stem cells: characterization and potential as therapy candidate for a large animal model of spinal cord injury. Stem Cells Transl Med. 2014;3:334-45 pubmed publisher
Göstring L, Malm M, Höidén Guthenberg I, Frejd F, Ståhl S, Löfblom J, et al. Cellular effects of HER3-specific affibody molecules. PLoS ONE. 2012;7:e40023 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Casazza A, Finisguerra V, Capparuccia L, Camperi A, Swiercz J, Rizzolio S, et al. Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice. J Clin Invest. 2010;120:2684-98 pubmed publisher
Sheng Q, Liu X, Fleming E, Yuan K, Piao H, Chen J, et al. An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells. Cancer Cell. 2010;17:298-310 pubmed publisher
Yamauchi J, Miyamoto Y, Chan J, Tanoue A. ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration. J Cell Biol. 2008;181:351-65 pubmed publisher
Barkho B, Song H, Aimone J, Smrt R, Kuwabara T, Nakashima K, et al. Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev. 2006;15:407-21 pubmed
Zhou B, Peyton M, He B, Liu C, Girard L, Caudler E, et al. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell. 2006;10:39-50 pubmed
Kastin A, Akerstrom V, Pan W. Neuregulin-1-beta1 enters brain and spinal cord by receptor-mediated transport. J Neurochem. 2004;88:965-70 pubmed
image
image 1 :
R&D Systems 377-HB-050 image 1
Recombinant Human NRG1-beta 1/HRG1-beta 1 ECD Protein Bioactivity
product information
brand :
R&D Systems
master code :
377-HB
SKU :
377-HB-050
product name :
Recombinant Human NRG1-beta 1/HRG1-beta 1 ECD Protein
description :
The Recombinant Human NRG1-beta 1/HRG1-beta 1 ECD Protein from R&D Systems is derived from E. coli. The Recombinant Human NRG1-beta 1/HRG1-beta 1 ECD Protein has been validated for the following applications: Bioactivity.
target :
Neuregulin-1 beta 1/NRG1 beta 1
category :
Proteins and Enzymes
sizes available :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
theoretical molecular weight :
26.9 kDa
gene symbol :
NRG1
details of functionality :
Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells. Karey, K.P. et al . (1988) Cancer Research 48 :4083. The ED50 for this effect is 2.5-12.5 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
AAA58639
applications :
Bioactivity
source :
E. coli-derived Recombinant Human NRG1-beta 1/HRG1-beta 1 ECD Protein
USD :
377
USD 2023 :
377 USD
alt names :
ARIA, GGF, GGF2, Heregulin-1, HGL, HRG, HRG1, HRG1-alpha, HRG1-beta 1, HRGA, MST131, MSTP131, NDF, neuregulin 1, Neuregulin1, Neuregulin1 beta 1, NRG1, NRG1-IT2, SMDF
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.