Recombinant Human MANF Protein, CF | R&D Systems 3748-MN-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human MANF Protein, CF

catalog :

3748-MN-050

quantity :

50 ug

price :

400 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Kitamura R, Hummel D, Ustione A, Piston D, Urano F. Dual role of neuroplastin in pancreatic β cells: Regulating insulin secretion and promoting islet inflammation. Proc Natl Acad Sci U S A. 2024;121:e2411234121 pubmed publisher
Zhao X, Wang Z, Wang J, Xu F, Zhang Y, Han D, et al. Mesencephalic astrocyte-derived neurotrophic factor (MANF) alleviates cerebral ischemia/reperfusion injury in mice by regulating microglia polarization via A20/NF-κB pathway. Int Immunopharmacol. 2024;127:111396 pubmed publisher
Mahadevan J, Morikawa S, Yagi T, Abreu D, Lu S, Kanekura K, et al. A soluble endoplasmic reticulum factor as regenerative therapy for Wolfram syndrome. Lab Invest. 2020;100:1197-1207 pubmed publisher
Park S, Kim Y, Yang S, Henderson M, Yang W, Lindahl M, et al. Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome. Proc Natl Acad Sci U S A. 2019;: pubmed publisher

product information

master code :

3748-MN

SKU :

3748-MN-050

product name :

Recombinant Human MANF Protein, CF

unit size :

50 ug

description :

The Recombinant Human MANF Protein, CF from R&D Systems is derived from NS0. The Recombinant Human MANF Protein, CF has been validated for the following applications: Bioactivity.

target :

MANF

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

20.4 kDa, reducing conditions

theoretical molecular weight :

19.0 kDa

gene symbol :

MANF

details of functionality :

Measured by its ability to support the survival and stimulate neurite outgrowth of rat embryonic cortical neurons. The ED50 for this effect is 0.7-2.8 ╡g/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

ACE87065

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human MANF protein Leu22-Leu179 with a C-terminal 6-His tag

source short :

NS0

USD :

400 USD

alt names :

Arginine-Rich Protein, arginine-rich, mutated in early stage tumors, ARMET, ARP, mesencephalic astrocyte-derived neurotrophic factor, Protein ARMET

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage