Recombinant Human TrkC Fc Chimera Protein | R&D Systems 373-TC-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human TrkC Fc Chimera Protein

catalog :

373-TC-050

quantity :

50 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Guo Y, Su Z, Chen Y, Chai Z. Brain-derived neurotrophic factor/neurotrophin 3 regulate axon initial segment location and affect neuronal excitability in cultured hippocampal neurons. J Neurochem. 2017;142:260-271 pubmed publisher
Sleigh J, Dawes J, West S, Wei N, Spaulding E, Gómez Martín A, et al. Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations. Proc Natl Acad Sci U S A. 2017;114:E3324-E3333 pubmed publisher
Vaegter C, Jansen P, Fjorback A, Glerup S, Skeldal S, Kjolby M, et al. Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nat Neurosci. 2011;14:54-61 pubmed publisher
Bouzas Rodriguez J, Cabrera J, Delloye Bourgeois C, Ichim G, Delcros J, Raquin M, et al. Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis. J Clin Invest. 2010;120:850-8 pubmed publisher
Lu B, PereiraPerrin M. A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi. Infect Immun. 2008;76:3530-8 pubmed publisher
Esper R, Loeb J. Rapid axoglial signaling mediated by neuregulin and neurotrophic factors. J Neurosci. 2004;24:6218-27 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

373-TC

SKU :

373-TC-050

product name :

Recombinant Human TrkC Fc Chimera Protein

Description :

The Recombinant Human TrkC Fc Chimera Protein from R&D Systems is derived from NS0. The Recombinant Human TrkC Fc Chimera Protein has been validated for the following applications: Bioactivity.

target :

TrkC

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

130-150 kDa, reducing conditions

theoretical molecular weight :

72 kDa (monomer)

gene symbol :

NTRK3

details of functionality :

Measured by its ability to inhibit NT-3-induced proliferation of BaF-TrkB-BD mouse pro-B cells transfected with TrkB. The ED50 for this effect is 0.05-0.2 µg/mL in the presence of 40 ng/mL of rhNT-3.

endotoxin note :

<0.1 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q96CY4

applications :

Bioactivity

source :

NS0-derived Recombinant Human TrkC Fc Chimera Protein

USD :

423 USD

alt names :

EC 2.7.10, EC 2.7.10.1, ETS related protein-neurotrophic receptor tyrosine kinase fusion protein, ETV6-NTRK3 fusion, gp145(trkC), GP145-TrkC, Neurotrophic tyrosine kinase receptor type 3, neurotrophic tyrosine kinase, receptor, type 3, NT 3 receptor, NT-3 growth factor receptor, NTRK3, Trk-C, TrkC tyrosine kinase, TRKCneurotrophin 3 receptor, tyrosine kinase receptor C

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage