Recombinant Human BMP-4/BMP-7 Heterodimer Protein, CF | R&D Systems 3727-BP-010/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human BMP-4/BMP-7 Heterodimer Protein, CF

catalog :

3727-BP-010/CF

quantity :

10 ug

price :

600 USD

more info or order :

R&D Systems product webpage

citations: 13

Reference
Sinha S, Biswas M, Chatterjee S, Kumar S, Sengupta A. Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling. Cell Rep. 2020;31:107570 pubmed publisher
Krouwels A, Iljas J, Kragten A, Dhert W, Oner F, Tryfonidou M, et al. Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration. Int J Mol Sci. 2020;21: pubmed publisher
Yuan Y, Li L, Cheng Q, Diao F, Zeng Q, Yang X, et al. In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids. Cell Res. 2020;30:244-255 pubmed publisher
Ho W, Freem L, Zhao D, Painter K, Woolley T, Gaffney E, et al. Feather arrays are patterned by interacting signalling and cell density waves. PLoS Biol. 2019;17:e3000132 pubmed publisher
Wagner I, Wang H, Weissert P, Straube W, Shevchenko A, Gentzel M, et al. Serum Proteases Potentiate BMP-Induced Cell Cycle Re-entry of Dedifferentiating Muscle Cells during Newt Limb Regeneration. Dev Cell. 2017;40:608-617.e6 pubmed publisher
van Andel H, Ren Z, Koopmans I, Joosten S, Kocemba K, de Lau W, et al. Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins. Proc Natl Acad Sci U S A. 2017;114:376-381 pubmed publisher
Dexheimer V, Gabler J, Bomans K, Sims T, Omlor G, Richter W. Differential expression of TGF-Î² superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation. Sci Rep. 2016;6:36655 pubmed publisher
Choudhary P, Whiting P. A strategy to ensure safety of stem cell-derived retinal pigment epithelium cells. Stem Cell Res Ther. 2016;7:127 pubmed publisher
Choudhary P, Dodsworth B, Sidders B, Gutteridge A, Michaelides C, Duckworth J, et al. A FOXM1 Dependent Mesenchymal-Epithelial Transition in Retinal Pigment Epithelium Cells. PLoS ONE. 2015;10:e0130379 pubmed publisher
Alexander C, Piloto S, Le Pabic P, Schilling T. Wnt signaling interacts with bmp and edn1 to regulate dorsal-ventral patterning and growth of the craniofacial skeleton. PLoS Genet. 2014;10:e1004479 pubmed publisher
Lewis C, Mardaryev A, Poterlowicz K, Sharova T, Aziz A, Sharpe D, et al. Bone morphogenetic protein signaling suppresses wound-induced skin repair by inhibiting keratinocyte proliferation and migration. J Invest Dermatol. 2014;134:827-837 pubmed publisher
Swapna I, Borodinsky L. Interplay between electrical activity and bone morphogenetic protein signaling regulates spinal neuron differentiation. Proc Natl Acad Sci U S A. 2012;109:16336-41 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

3727-BP/CF

SKU :

3727-BP-010/CF

product name :

Recombinant Human BMP-4/BMP-7 Heterodimer Protein, CF

Description :

The Recombinant Human BMP-4/BMP-7 Heterodimer Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human BMP-4/BMP-7 Heterodimer Protein, CF has been validated for the following applications: Bioactivity.

target :

BMP-4/BMP-7 Heterodimer

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

theoretical molecular weight :

13.3 kDa (BMP-4), 15.8 kDa (BMP-7)

gene symbol :

BMP4

details of functionality :

Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al . (1999) Exp. Cell Res. 250 :351. The ED50 for this effect is 15-75 ng/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P12644 (BMP-4) P18075 (BMP-7)

applications :

Bioactivity

source :

E. coli-derived Recombinant Human BMP-4/BMP-7 Heterodimer Protein

USD :

600 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage