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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human TNF RI/TNFRSF1A Fc Chimera Protein, CF
catalog :
372-RI-050/CF
quantity :
50 ug
price :
394 USD
more info or order :
R&D Systems product webpage
citations: 11
Reference
Lightwood D, Munro R, Porter J, McMillan D, Carrington B, Turner A, et al. A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF. Nat Commun. 2021;12:583 pubmed publisher
Tyrinova T, Leplina O, Mishinov S, Tikhonova M, Dolgova E, Proskurina A, et al. Defective Regulation of Membrane TNFα Expression in Dendritic Cells of Glioblastoma Patients Leads to the Impairment of Cytotoxic Activity against Autologous Tumor Cells. Int J Mol Sci. 2020;21: pubmed publisher
Inoue M, Ando D, Kamada H, Taki S, Niiyama M, Mukai Y, et al. A trimeric structural fusion of an antagonistic tumor necrosis factor-α mutant enhances molecular stability and enables facile modification. J Biol Chem. 2017;292:6438-6451 pubmed publisher
Chen C, Chen L, Hsu Y, Liu K, Fan C, Huang T. The endothelin-integrin axis is involved in macrophage-induced breast cancer cell chemotactic interactions with endothelial cells. J Biol Chem. 2014;289:10029-44 pubmed publisher
Moh M, Lorenzini P, Gullo C, Schwarz H. Tumor necrosis factor receptor 1 associates with CD137 ligand and mediates its reverse signaling. FASEB J. 2013;27:2957-66 pubmed publisher
Cosgrove C, Ussher J, Rauch A, Gärtner K, Kurioka A, Hühn M, et al. Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection. Blood. 2013;121:951-61 pubmed publisher
Lu B, PereiraPerrin M. A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi. Infect Immun. 2008;76:3530-8 pubmed publisher
Narita M, Shimamura M, Imai S, Kubota C, Yajima Y, Takagi T, et al. Role of interleukin-1beta and tumor necrosis factor-alpha-dependent expression of cyclooxygenase-2 mRNA in thermal hyperalgesia induced by chronic inflammation in mice. Neuroscience. 2008;152:477-86 pubmed publisher
Hu P, Han Z, Couvillon A, Kaufman R, Exton J. Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol. 2006;26:3071-84 pubmed
Hawari F, Rouhani F, Cui X, Yu Z, Buckley C, Kaler M, et al. Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: a mechanism for generation of soluble cytokine receptors. Proc Natl Acad Sci U S A. 2004;101:1297-302 pubmed
Bretz J, Mezosi E, Giordano T, Gauger P, Thompson N, Baker J. Inflammatory cytokine regulation of TRAIL-mediated apoptosis in thyroid epithelial cells. Cell Death Differ. 2002;9:274-86 pubmed
product information
brand :
R&D Systems
master code :
372-RI/CF
SKU :
372-RI-050/CF
product name :
Recombinant Human TNF RI/TNFRSF1A Fc Chimera Protein, CF
description :
The Recombinant Human TNF RI/TNFRSF1A Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human TNF RI/TNFRSF1A Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
TNF RI/TNFRSF1A
category :
Proteins and Enzymes
sizes available :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
60-66 kDa, reducing conditions
theoretical molecular weight :
48 kDa (monomer)
gene symbol :
TNFRSF1A
details of functionality :
Measured by its ability to inhibit the TNF-alpha mediated cytotoxicity in the L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. Matthews, N. and M.L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al . (eds): IRL Press. 221. The ED50 for this effect is 0.4-2 ng/mL in the presence of 0.25 ng/mL Recombinant Human TNF-alpha (Catalog # 210-TA ).
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P19438
applications :
Bioactivity
source :
NS0-derived Recombinant Human TNF RI/TNFRSF1A Fc Chimera Protein, CF
USD :
388
USD 2023 :
394 USD
alt names :
CD120a, CD120a antigen, FPF, p55, p55-R, p60, TNFARMGC19588, TNF-R, TNF-R1, TNFR1TBP1, TNFR55, TNF-R55, TNFR60, TNFRI, TNF-RI, TNF-R-I, TNFR-I, TNFRSF1A, tumor necrosis factor binding protein 1, Tumor necrosis factor receptor 1, tumor necrosis factor receptor 1A isoform beta, tumor necrosis factor receptor superfamily member 1A, tumor necrosis factor receptor superfamily, member 1A, tumor necrosis factor receptor type 1, Tumor necrosis factor receptor type I, tumor necrosis factor-alpha receptor
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.