product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human FAP Protein, CF
catalog :
3715-SE-010
quantity :
10 ug
price :
345 USD
more info or order :
R&D Systems product webpage
citations: 11
Reference
Xi C, Di Fazio A, Nadvi N, Xiang M, Zhang H, Deshpande C, et al. An improved production and purification protocol for recombinant soluble human fibroblast activation protein alpha. Protein Expr Purif. 2021;181:105833 pubmed publisher
Cho J, Yang E, Quan W, Nam E, Cheon H. Discovery of a novel fibroblast activation protein (FAP) inhibitor, BR103354, with anti-diabetic and anti-steatotic effects. Sci Rep. 2020;10:21280 pubmed publisher
Wang R, Zhang C, Zheng C, Li H, Xie X, Jin Y, et al. Introduction of Z-GP scaffold into procarbazine reduces spermatoxicity and myelosuppression. Bioorg Chem. 2018;83:461-467 pubmed publisher
Chai X, Sun G, Fang Y, Hu L, Liu X, Zhang X. Tumor-targeting efficacy of a BF211 prodrug through hydrolysis by fibroblast activation protein-?. Acta Pharmacol Sin. 2017;: pubmed publisher
Chen M, Lei X, Shi C, Huang M, Li X, Wu B, et al. Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents. J Clin Invest. 2017;127:3689-3701 pubmed publisher
Uitte de Willige S, Keane F, Bowen D, Malfliet J, Zhang H, Maneck B, et al. Circulating fibroblast activation protein activity and antigen levels correlate strongly when measured in liver disease and coronary heart disease. PLoS ONE. 2017;12:e0178987 pubmed publisher
Errarte P, Guarch R, Pulido R, Blanco L, Nunes Xavier C, Beitia M, et al. The Expression of Fibroblast Activation Protein in Clear Cell Renal Cell Carcinomas Is Associated with Synchronous Lymph Node Metastases. PLoS ONE. 2016;11:e0169105 pubmed publisher
Grindel B, Martinez J, Pennington C, Muldoon M, Stave J, Chung L, et al. Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior. Matrix Biol. 2014;36:64-76 pubmed publisher
Keane F, Yao T, Seelk S, Gall M, Chowdhury S, Poplawski S, et al. Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. FEBS Open Bio. 2013;4:43-54 pubmed publisher
Fischer E, Chaitanya K, Wüest T, Wadle A, Scott A, Van Den Broek M, et al. Radioimmunotherapy of fibroblast activation protein positive tumors by rapidly internalizing antibodies. Clin Cancer Res. 2012;18:6208-18 pubmed publisher
Keane F, Nadvi N, Yao T, Gorrell M. Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-?. FEBS J. 2011;278:1316-32 pubmed publisher
image
image 1 :
R&D Systems 3715-SE-010 image 1
Recombinant Human FAP Protein Enzyme Activity
product information
brand :
R&D Systems
master code :
3715-SE
SKU :
3715-SE-010
product name :
Recombinant Human FAP Protein, CF
unit size :
10 ug
description :
SH2 domain-containing inositol 5 -phosphatase 2 (SHIP2) inhibitor
target :
Fibroblast Activation Protein alpha/FAP
category :
Proteins and Enzymes
alt names :
170 kDa melanoma membrane-bound gelatinase, DKFZp686G13158, DPPIV, EC 3.4.21.-, FAP, FAPA, Fibroblast activation protein alpha, fibroblast activation protein, alpha, Integral membrane serine protease, seprase, vibronectin
buffer :
Supplied as a 0.2 µm filtered solution in Tris, NaCl and Glycerol.
conjugate :
Unconjugated
all available conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.
observed molecular weight :
85 kDa, reducing conditions
theoretical molecular weight :
86 kDa
gene symbol :
FAP
details of functionality :
Measured by its ability to convert the substrate benzyloxycarbonyl-Gly-Pro-7-amido-4-methylcoumarin (Z-GP-AMC) to Z-Gly-Pro and 7-amino-4-methylcoumarin (AMC). The specific activity is 1800 pmol/min/µg, as measured under the described conditions.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q12884
applications :
Enzyme Activity
source :
Sf 21 (baculovirus)-derived Recombinant Human FAP Protein, CF
USD :
319
Jul-22 :
345 USD
sizes available :
10 ug
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.