Recombinant Human FAP Protein, CF | R&D Systems 3715-SE-010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human FAP Protein, CF

catalog :

3715-SE-010

quantity :

10 ug

price :

385 USD

citations: 17

Reference
Weiner L, Fitzgerald A, Maynard R, Marcisak E, Nasir A, Glasgow E, et al. Fibroblast activation protein regulates natural killer cell migration, extravasation and tumor infiltration. Res Sq. 2023;: pubmed publisher
Ren H, Zeng X, Zhao X, Hou D, Yao H, Yaseen M, et al. A bioactivated in vivo assembly nanotechnology fabricated NIR probe for small pancreatic tumor intraoperative imaging. Nat Commun. 2022;13:418 pubmed publisher
Hintz H, Snyder K, Wu J, Hullsiek R, Dahlvang J, Hart G, et al. Simultaneous Engagement of Tumor and Stroma Targeting Antibodies by Engineered NK-92 Cells Expressing CD64 Controls Prostate Cancer Growth. Cancer Immunol Res. 2021;9:1270-1282 pubmed publisher
Xi C, Di Fazio A, Nadvi N, Xiang M, Zhang H, Deshpande C, et al. An improved production and purification protocol for recombinant soluble human fibroblast activation protein alpha. Protein Expr Purif. 2021;181:105833 pubmed publisher
Cho J, Yang E, Quan W, Nam E, Cheon H. Discovery of a novel fibroblast activation protein (FAP) inhibitor, BR103354, with anti-diabetic and anti-steatotic effects. Sci Rep. 2020;10:21280 pubmed publisher
Wei H, Xu Y, Wang Y, Xu L, Mo C, Li L, et al. Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target. Cell Rep. 2020;33:108252 pubmed publisher
Wang X, Gessier F, Perozzo R, Stojkov D, Hosseini A, Amirshahrokhi K, et al. RIPK3-MLKL-Mediated Neutrophil Death Requires Concurrent Activation of Fibroblast Activation Protein-α. J Immunol. 2020;205:1653-1663 pubmed publisher
Wang R, Zhang C, Zheng C, Li H, Xie X, Jin Y, et al. Introduction of Z-GP scaffold into procarbazine reduces spermatoxicity and myelosuppression. Bioorg Chem. 2018;83:461-467 pubmed publisher
Chai X, Sun G, Fang Y, Hu L, Liu X, Zhang X. Tumor-targeting efficacy of a BF211 prodrug through hydrolysis by fibroblast activation protein-?. Acta Pharmacol Sin. 2017;: pubmed publisher
Chen M, Lei X, Shi C, Huang M, Li X, Wu B, et al. Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents. J Clin Invest. 2017;127:3689-3701 pubmed publisher
Uitte de Willige S, Keane F, Bowen D, Malfliet J, Zhang H, Maneck B, et al. Circulating fibroblast activation protein activity and antigen levels correlate strongly when measured in liver disease and coronary heart disease. PLoS ONE. 2017;12:e0178987 pubmed publisher
Errarte P, Guarch R, Pulido R, Blanco L, Nunes Xavier C, Beitia M, et al. The Expression of Fibroblast Activation Protein in Clear Cell Renal Cell Carcinomas Is Associated with Synchronous Lymph Node Metastases. PLoS ONE. 2016;11:e0169105 pubmed publisher
Dunshee D, Bainbridge T, Kljavin N, Zavala Solorio J, Schroeder A, Chan R, et al. Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21. J Biol Chem. 2016;291:5986-96 pubmed publisher
Grindel B, Martinez J, Pennington C, Muldoon M, Stave J, Chung L, et al. Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior. Matrix Biol. 2014;36:64-76 pubmed publisher
Keane F, Yao T, Seelk S, Gall M, Chowdhury S, Poplawski S, et al. Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. FEBS Open Bio. 2013;4:43-54 pubmed publisher
Fischer E, Chaitanya K, Wüest T, Wadle A, Scott A, Van Den Broek M, et al. Radioimmunotherapy of fibroblast activation protein positive tumors by rapidly internalizing antibodies. Clin Cancer Res. 2012;18:6208-18 pubmed publisher
Keane F, Nadvi N, Yao T, Gorrell M. Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-?. FEBS J. 2011;278:1316-32 pubmed publisher

product information

master code :

3715-SE

SKU :

3715-SE-010

product name :

Recombinant Human FAP Protein, CF

unit size :

10 ug

description :

The Recombinant Human FAP Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human FAP Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Fibroblast Activation Protein alpha/FAP

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in Tris, NaCl and Glycerol.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

85 kDa, reducing conditions

theoretical molecular weight :

86 kDa

gene symbol :

FAP

details of functionality :

Measured by its ability to convert the substrate benzyloxycarbonyl-Gly-Pro-7-amido-4-methylcoumarin (Z-GP-AMC) to Z-Gly-Pro and 7-amino-4-methylcoumarin (AMC). The specific activity is 1800 pmol/min/╡g, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q12884

applications :

Enzyme Activity

source long :

Spodoptera frugiperda , Sf 21 (baculovirus)-derived human Fibroblast Activation Protein alpha/FAP protein Leu26-Asp760, with an N-terminal 6-His tag

source short :

Sf 21 (baculovirus)

extended description :

Analyzed by SEC-MALS

USD :

385 USD

product details :

Analyzed by SEC-MALS

alt names :

170 kDa melanoma membrane-bound gelatinase, DKFZp686G13158, DPPIV, EC 3.4.21.-, FAP, FAPA, Fibroblast activation protein alpha, fibroblast activation protein, alpha, Integral membrane serine protease, seprase, vibronectin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 ░C as supplied. 3 months, -70 ░C under sterile conditions after opening.