product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human ALK-1 Fc Chimera Protein, CF
catalog :
370-AL-100
quantity :
100 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 16
Reference
Cheng Y, Anzell A, Morosky S, Schwartze T, Hinck C, Hinck A, et al. Shear Stress and Sub-Femtomolar Levels of Ligand Synergize to Activate ALK1 Signaling in Endothelial Cells. Cells. 2024;13: pubmed publisher
Mendez P, Obendorf L, Jatzlau J, Burdzinski W, Reichenbach M, Nageswaran V, et al. Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes. BMC Biol. 2022;20:210 pubmed publisher
Guo J, Liu B, Thorikay M, Yu M, Li X, Tong Z, et al. Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Nat Commun. 2022;13:2395 pubmed publisher
Toyonaga T, Steinbach E, Keith B, Barrow J, Schaner M, Wolber E, et al. Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients With Crohn's Disease. Cell Mol Gastroenterol Hepatol. 2020;10:779-796 pubmed publisher
Wu J, Wei B, Shi Y, Lu X, Ding Y, Wang C, et al. Homoharringtonine enhances the effect of imatinib on chronic myelogenous leukemia cells by downregulating ZFX. Mol Med Rep. 2019;20:3233-3239 pubmed publisher
Olsen O, Skjærvik A, Størdal B, Sundan A, Holien T. TGF-? contamination of purified recombinant GDF15. PLoS ONE. 2017;12:e0187349 pubmed publisher
Ruiz S, Zhao H, Chandakkar P, Chatterjee P, Papoin J, Blanc L, et al. A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10. Sci Rep. 2016;5:37366 pubmed publisher
Kraehling J, Chidlow J, Rajagopal C, Sugiyama M, Fowler J, Lee M, et al. Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells. Nat Commun. 2016;7:13516 pubmed publisher
Wöltje K, Jabs M, Fischer A. Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells. PLoS ONE. 2015;10:e0120547 pubmed publisher
Wu Q, Sun C, Lin H, Babitt J. Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS ONE. 2012;7:e46307 pubmed publisher
van Meeteren L, Thorikay M, Bergqvist S, Pardali E, Stampino C, Hu Lowe D, et al. Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting. J Biol Chem. 2012;287:18551-61 pubmed publisher
Yao Y, Jumabay M, Ly A, Radparvar M, Wang A, Abdmaulen R, et al. Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium. Blood. 2012;119:5037-47 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Korff T, Aufgebauer K, Hecker M. Cyclic stretch controls the expression of CD40 in endothelial cells by changing their transforming growth factor-beta1 response. Circulation. 2007;116:2288-97 pubmed
Ungefroren H, Schniewind B, Groth S, Chen W, Müerköster S, Kalthoff H, et al. Antitumor activity of ALK1 in pancreatic carcinoma cells. Int J Cancer. 2007;120:1641-51 pubmed
David L, Mallet C, Mazerbourg S, Feige J, Bailly S. Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood. 2007;109:1953-61 pubmed
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
370-AL
SKU :
370-AL-100
product name :
Recombinant Human ALK-1 Fc Chimera Protein, CF
description :
The Recombinant Human ALK-1 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ALK-1 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
ALK-1
unit size :
100 ug
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
observed molecular weight :
50-55 kDa, reducing conditions
theoretical molecular weight :
37.3 kDa (monomer)
gene symbol :
ACVRL1
details of functionality :
Measured by its ability to inhibit BMP-9-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. David, L. et al . (2007) Blood 109 :1953. The ED50 for this effect is 3-12 ng/mL in the presence of 2 ng/mL of rhBMP-9.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P37023
applications :
Bioactivity
product keywords :
370-AL, rhALK-1/Fc Chimera, hALK-1 Chimera, carrier-free, carrier free, 37O-AL, 370AL, ALK1, ALK 1, cytokine, cytokines
source :
NS0-derived Recombinant Human ALK-1 Fc Chimera Protein, CF
USD :
423
USD 2025 :
432 USD
alt names :
activin A receptor type II-like 1, activin A receptor, type II-like kinase 1, Activin receptor-like kinase 1, ACVRL1, ACVRLK1ORW2, ALK1, ALK-1, ALK1TGF-B superfamily receptor type I, EC 2.7.11, HHT, HHT2EC 2.7.11.30, serine/threonine-protein kinase receptor R3, SKR3, TSR-I
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.