Recombinant Human ALK-1 Fc Chimera Protein, CF | R&D Systems 370-AL-100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ALK-1 Fc Chimera Protein, CF

catalog :

370-AL-100

quantity :

100 ug

price :

432 USD

citations: 17

Reference
Cheng Y, Anzell A, Morosky S, Schwartze T, Hinck C, Hinck A, et al. Shear Stress and Sub-Femtomolar Levels of Ligand Synergize to Activate ALK1 Signaling in Endothelial Cells. Cells. 2024;13: pubmed publisher
Mendez P, Obendorf L, Jatzlau J, Burdzinski W, Reichenbach M, Nageswaran V, et al. Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes. BMC Biol. 2022;20:210 pubmed publisher
Guo J, Liu B, Thorikay M, Yu M, Li X, Tong Z, et al. Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Nat Commun. 2022;13:2395 pubmed publisher
Toyonaga T, Steinbach E, Keith B, Barrow J, Schaner M, Wolber E, et al. Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients With Crohn's Disease. Cell Mol Gastroenterol Hepatol. 2020;10:779-796 pubmed publisher
Wu J, Wei B, Shi Y, Lu X, Ding Y, Wang C, et al. Homoharringtonine enhances the effect of imatinib on chronic myelogenous leukemia cells by downregulating ZFX. Mol Med Rep. 2019;20:3233-3239 pubmed publisher
Neto F, Klaus Bergmann A, Ong Y, Alt S, Vion A, Szymborska A, et al. YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development. elife. 2018;7: pubmed publisher
Olsen O, Skjærvik A, Størdal B, Sundan A, Holien T. TGF-? contamination of purified recombinant GDF15. PLoS ONE. 2017;12:e0187349 pubmed publisher
Ruiz S, Zhao H, Chandakkar P, Chatterjee P, Papoin J, Blanc L, et al. A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10. Sci Rep. 2016;5:37366 pubmed publisher
Kraehling J, Chidlow J, Rajagopal C, Sugiyama M, Fowler J, Lee M, et al. Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells. Nat Commun. 2016;7:13516 pubmed publisher
WÃ¶ltje K, Jabs M, Fischer A. Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells. PLoS ONE. 2015;10:e0120547 pubmed publisher
Wu Q, Sun C, Lin H, Babitt J. Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS ONE. 2012;7:e46307 pubmed publisher
van Meeteren L, Thorikay M, Bergqvist S, Pardali E, Stampino C, Hu Lowe D, et al. Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting. J Biol Chem. 2012;287:18551-61 pubmed publisher
Yao Y, Jumabay M, Ly A, Radparvar M, Wang A, Abdmaulen R, et al. Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium. Blood. 2012;119:5037-47 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Korff T, Aufgebauer K, Hecker M. Cyclic stretch controls the expression of CD40 in endothelial cells by changing their transforming growth factor-beta1 response. Circulation. 2007;116:2288-97 pubmed
Ungefroren H, Schniewind B, Groth S, Chen W, Müerköster S, Kalthoff H, et al. Antitumor activity of ALK1 in pancreatic carcinoma cells. Int J Cancer. 2007;120:1641-51 pubmed
David L, Mallet C, Mazerbourg S, Feige J, Bailly S. Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood. 2007;109:1953-61 pubmed

product information

master code :

370-AL

SKU :

370-AL-100

product name :

Recombinant Human ALK-1 Fc Chimera Protein, CF

unit size :

100 ug

description :

The Recombinant Human ALK-1 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ALK-1 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

ALK-1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

50-55 kDa, reducing conditions

theoretical molecular weight :

37.3 kDa (monomer)

gene symbol :

ACVRL1

details of functionality :

Measured by its ability to inhibit BMP-9-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. David, L. et al . (2007) Blood 109 :1953. The ED50 for this effect is 3-12 ng/mL in the presence of 2 ng/mL of rhBMP-9.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P37023

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human ALK-1 protein Human ALK-1 (Asp22 - Gln118) Accession # P37023.2 IEGRID Human IgG1 (Pro100 - Lys330) N-terminus C-terminus

source short :

NS0

USD :

432 USD

alt names :

activin A receptor type II-like 1, activin A receptor, type II-like kinase 1, Activin receptor-like kinase 1, ACVRL1, ACVRLK1ORW2, ALK1, ALK-1, ALK1TGF-B superfamily receptor type I, EC 2.7.11, HHT, HHT2EC 2.7.11.30, serine/threonine-protein kinase receptor R3, SKR3, TSR-I

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.