Recombinant Human Complement Component C3a Protein, CF | R&D Systems 3677-C3-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Complement Component C3a Protein, CF

catalog :

3677-C3-025

quantity :

25 ug

price :

487 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, et al. Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nat Chem Biol. 2023;19:1351-1360 pubmed publisher
Plant Hately A, Eryilmaz B, David C, Brain D, Heaton B, Perrie Y, et al. Exposure of the Basophilic Cell Line KU812 to Liposomes Reveals Activation Profiles Associated with Potential Anaphylactic Responses Linked to Physico-Chemical Characteristics. Pharmaceutics. 2022;14: pubmed publisher
Fernandez Godino R, Pierce E. C3a triggers formation of sub-retinal pigment epithelium deposits via the ubiquitin proteasome pathway. Sci Rep. 2018;8:9679 pubmed publisher
Wang C, Cao S, Zhang D, Li H, Kijlstra A, Yang P. Increased Complement 3a Receptor is Associated with Behcet's disease and Vogt-Koyanagi-Harada disease. Sci Rep. 2017;7:15579 pubmed publisher
Samstad E, Niyonzima N, Nymo S, Aune M, Ryan L, Bakke S, et al. Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release. J Immunol. 2014;192:2837-45 pubmed publisher
Jensen B, Frandsen P, Raaby E, Schiøtz P, Skov P, Poulsen L. Molecular and stimulus-response profiles illustrate heterogeneity between peripheral and cord blood-derived human mast cells. J Leukoc Biol. 2014;95:893-901 pubmed publisher
Conroy A, Liles W, Molyneux M, Rogerson S, Kain K. Performance characteristics of combinations of host biomarkers to identify women with occult placental malaria: a case-control study from Malawi. PLoS ONE. 2011;6:e28540 pubmed publisher
Ruan B, Li X, Winkler A, Cunningham K, Kuai J, Greco R, et al. Complement C3a, CpG oligos, and DNA/C3a complex stimulate IFN-? production in a receptor for advanced glycation end product-dependent manner. J Immunol. 2010;185:4213-22 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

3677-C3

SKU :

3677-C3-025

product name :

Recombinant Human Complement Component C3a Protein, CF

Description :

The Recombinant Human Complement Component C3a Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Complement Component C3a Protein, CF has been validated for the following applications: Bioactivity.

target :

Complement Component C3a

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

theoretical molecular weight :

9.1 kDa

gene symbol :

details of functionality :

Measured by its ability to enhance IL-6 secretion by human peripheral blood mononuclear cells (PBMC). Fischer, W.H. et al . (1999) J. Immunol. 162 :453. The ED50 for this effect is 1.5-7.5 µg/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

NP_000055

applications :

Bioactivity

source :

E. coli-derived Recombinant Human Complement Component C3a Protein

USD :

487 USD

alt names :

AHUS5;ARMD9;ASP;C3a;C3b;Complement C3;CPAMD1;HEL-S-62p, Anaphylatoxin, C3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage