This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human NGFR/TNFRSF16 Fc Chimera Protein
catalog :
367-NR
quantity :
50 ug
price :
339 USD
citations: 8
Reference
Suzuki A, Matsuura D, Kanatani H, Yano S, Tsunakawa M, Matsuyama S, et al. Inhibitory Effects of Polyacetylene Compounds from Panax ginseng on Neurotrophin Receptor-Mediated Hair Growth. Biol Pharm Bull. 2017;40:1784-1788 pubmed publisher
Jia R, Shepheard S, Jin J, Hu F, Zhao X, Xue L, et al. Urinary Extracellular Domain of Neurotrophin Receptor p75 as a Biomarker for Amyotrophic Lateral Sclerosis in a Chinese cohort. Sci Rep. 2017;7:5127 pubmed publisher
Shepheard S, Wuu J, Cardoso M, Wiklendt L, Dinning P, Chataway T, et al. Urinary p75ECD: A prognostic, disease progression, and pharmacodynamic biomarker in ALS. Neurology. 2017;88:1137-1143 pubmed publisher
Adams R, Burnley R, Valenzano C, Qureshi O, Doyle C, Lumb S, et al. Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling. Sci Rep. 2017;7:37716 pubmed publisher
Shepheard S, Chataway T, Schultz D, Rush R, Rogers M. The extracellular domain of neurotrophin receptor p75 as a candidate biomarker for amyotrophic lateral sclerosis. PLoS ONE. 2014;9:e87398 pubmed publisher
Fobian K, Owczarek S, Budtz C, Bock E, Berezin V, Pedersen M. Peptides derived from the solvent-exposed loops 3 and 4 of BDNF bind TrkB and p75(NTR) receptors and stimulate neurite outgrowth and survival. J Neurosci Res. 2010;88:1170-81 pubmed publisher
Lu B, PereiraPerrin M. A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi. Infect Immun. 2008;76:3530-8 pubmed publisher
Song X, Zhong J, Wang X, Zhou X. Suppression of p75NTR does not promote regeneration of injured spinal cord in mice. J Neurosci. 2004;24:542-6 pubmed
product information
brand :
R&D Systems
master code :
367-NR
SKU :
367-NR-050
product name :
Recombinant Human NGFR/TNFRSF16 Fc Chimera Protein
description :
The Recombinant Human NGFR/TNFRSF16 Fc Chimera Protein from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human NGFR/TNFRSF16 Fc Chimera Protein has been validated for the following applications: Bioactivity.
target :
NGFR/TNFRSF16/p75NTR
category :
Proteins and Enzymes
unit size :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
70-80 kDa, reducing conditions
theoretical molecular weight :
51 kDa (monomer)
gene symbol :
NGFR
details of functionality :
Measured by its ability to inhibit beta-NGF-dependent proliferation of TF-1 human erythroleukemic cells. Kitamura, T. et al . (1989) J. Cell Physiol. 140 :323. The ED50 for this effect is 0.2-0.6 µg/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
catalog number base :
367-NR
accessionNumbers :
P08138
applications :
Bioactivity
source :
Spodoptera frugiperda , Sf 21 (baculovirus)-derived human NGF R/TNFRSF16 protein Human NGF R Lys29-Asn250 Accession # P08138 DIEGRMD Human IgG1 (Pro100-Lys330) 6-His tag N-terminus C-terminus
2020 USD :
339
2021 USD :
339 USD
alt names :
CD271, CD271 antigen, Gp80-LNGFR, member 16, nerve growth factor receptor, NGF R, NGF receptor, p75 ICD, p75 NTR, TNFRSF16, TNFRSF16nerve growth factor receptor (TNFR superfamily, member 16), tumor necrosis factor receptor superfamily member 16
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.