Recombinant Human CD44 Fc Chimera Protein, CF | R&D Systems 3660-CD-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CD44 Fc Chimera Protein, CF

catalog :

3660-CD-050

quantity :

50 ug

price :

394 USD

more info or order :

R&D Systems product webpage

citations: 10

Reference
Yusupov M, Privat Maldonado A, Cordeiro R, Verswyvel H, Shaw P, Razzokov J, et al. Oxidative damage to hyaluronan-CD44 interactions as an underlying mechanism of action of oxidative stress-inducing cancer therapy. Redox Biol. 2021;43:101968 pubmed publisher
Khan F, Gurung S, Gunassekaran G, Vadevoo S, Chi L, Permpoon U, et al. Identification of novel CD44v6-binding peptides that block CD44v6 and deliver a pro-apoptotic peptide to tumors to inhibit tumor growth and metastasis in mice. Theranostics. 2021;11:1326-1344 pubmed publisher
Guo J, Chiu C, Wang M, Li F, Chen J. Proteoglycan serglycin promotes non-small cell lung cancer cell migration through the interaction of its glycosaminoglycans with CD44. J Biomed Sci. 2020;27:2 pubmed publisher
Eggink L, Roby K, Cote R, Kenneth Hoober J. An innovative immunotherapeutic strategy for ovarian cancer: CLEC10A and glycomimetic peptides. J Immunother Cancer. 2018;6:28 pubmed publisher
Qadri M, Almadani S, Jay G, Elsaid K. Role of CD44 in Regulating TLR2 Activation of Human Macrophages and Downstream Expression of Proinflammatory Cytokines. J Immunol. 2018;200:758-767 pubmed publisher
Pepin M, Mezouar S, Pegon J, Muczynski V, Adam F, Bianchini E, et al. Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity. Sci Rep. 2016;6:37953 pubmed publisher
Kellett Clarke H, Stegmann M, Barclay A, Metcalfe C. CD44 Binding to Hyaluronic Acid Is Redox Regulated by a Labile Disulfide Bond in the Hyaluronic Acid Binding Site. PLoS ONE. 2015;10:e0138137 pubmed publisher
van den Berg L, Cardinaud S, van der Aar A, Sprokholt J, de Jong M, Zijlstra Willems E, et al. Langerhans Cell-Dendritic Cell Cross-Talk via Langerin and Hyaluronic Acid Mediates Antigen Transfer and Cross-Presentation of HIV-1. J Immunol. 2015;195:1763-73 pubmed publisher
Ayala Lujan J, Vijayakumar V, Gong M, Smith R, Santiago A, Ruiz Perez F. Broad spectrum activity of a lectin-like bacterial serine protease family on human leukocytes. PLoS ONE. 2014;9:e107920 pubmed publisher
Kohga K, Takehara T, Tatsumi T, Miyagi T, Ishida H, Ohkawa K, et al. Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma. Cancer Res. 2009;69:8050-7 pubmed publisher

product information

brand :

R&D Systems

master code :

3660-CD

SKU :

3660-CD-050

product name :

Recombinant Human CD44 Fc Chimera Protein, CF

description :

The Recombinant Human CD44 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human CD44 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

CD44

category :

Proteins and Enzymes

sizes available :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

72-86 kDa, reducing conditions

theoretical molecular weight :

48.6 kDa (monomer)

gene symbol :

CD44

details of functionality :

Measured by its ability to bind biotinylated hyaluronan in a functional ELISA with an estimated Kd 0.6 nM.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P16070

applications :

Binding Activity

source :

NS0-derived Recombinant Human CD44 Fc Chimera Protein, CF

USD :

388

USD 2023 :

394 USD

alt names :

CD44, CD44 antigen, CD44 molecule (Indian blood group), CD44R, CDw44, cell surface glycoprotein CD44, chondroitin sulfate proteoglycan 8, CSPG8, ECMR-III, Epican, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, HCAM, HCELL, hematopoietic cell E- and L-selectin ligand, Heparan sulfate proteoglycan, Hermes antigen, homing function and Indian blood group system, HUTCH-I, Hyaluronate receptor, IN, LHR, MC56, MDU2, MDU2CD44 antigen (homing function and Indian blood group system), MDU3, MDU3CDW44, MIC4, MIC4MGC10468, MUTCH-I, Pgp1, PGP-1, PGP-I, Phagocytic glycoprotein 1, Phagocytic glycoprotein I

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage