Recombinant Human CX3CL1/Fractalkine (Full Length) Protein | R&D Systems 365-FR-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CX3CL1/Fractalkine (Full Length) Protein

catalog :

365-FR-025

quantity :

25 ug

price :

407 USD

more info or order :

R&D Systems product webpage

citations: 21

Reference
Haage V, Tuddenham J, Comandante Lou N, Bautista A, Monzel A, Chiu R, et al. A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease. bioRxiv. 2024;: pubmed publisher
Wellemans V, Benhassou H, Fuselier E, Bellesort F, Dury S, Lebargy F, et al. Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells. iScience. 2021;24:103433 pubmed publisher
Muraoka S, Kaneko K, Motomura K, Nishio J, Nanki T. CX3CL1/fractalkine regulates the differentiation of human peripheral blood monocytes and monocyte-derived dendritic cells into osteoclasts. Cytokine. 2021;146:155652 pubmed publisher
Jamal Jameel K, Gallert W, Yanik S, Panek S, Kronsbein J, Jungck D, et al. Biomarkers for Comorbidities Modulate the Activity of T-Cells in COPD. Int J Mol Sci. 2021;22: pubmed publisher
Li J, Wuethrich A, Sina A, Cheng H, Wang Y, Behren A, et al. A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy. Nat Commun. 2021;12:1087 pubmed publisher
Saito K, Iioka H, Maruyama S, Sumardika I, Sakaguchi M, Kondo E. PODXL1 promotes metastasis of the pancreatic ductal adenocarcinoma by activating the C5aR/C5a axis from the tumor microenvironment. Neoplasia. 2019;21:1121-1132 pubmed publisher
Collar A, Swamydas M, O Hayre M, Sajib M, Hoffman K, Singh S, et al. The homozygous CX3CR1-M280 mutation impairs human monocyte survival. JCI Insight. 2018;3: pubmed publisher
Bolos M, Llorens Martín M, Perea J, Jurado Arjona J, Rabano A, Hernandez F, et al. Absence of CX3CR1 impairs the internalization of Tau by microglia. Mol Neurodegener. 2017;12:59 pubmed publisher
Ayala Lujan J, Vijayakumar V, Gong M, Smith R, Santiago A, Ruiz Perez F. Broad spectrum activity of a lectin-like bacterial serine protease family on human leukocytes. PLoS ONE. 2014;9:e107920 pubmed publisher
van Gils J, Ramkhelawon B, Fernandes L, Stewart M, Guo L, Seibert T, et al. Endothelial expression of guidance cues in vessel wall homeostasis dysregulation under proatherosclerotic conditions. Arterioscler Thromb Vasc Biol. 2013;33:911-9 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Truman L, Ford C, Pasikowska M, Pound J, Wilkinson S, Dumitriu I, et al. CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis. Blood. 2008;112:5026-36 pubmed publisher
Hermand P, Pincet F, Carvalho S, Ansanay H, Trinquet E, Daoudi M, et al. Functional adhesiveness of the CX3CL1 chemokine requires its aggregation. Role of the transmembrane domain. J Biol Chem. 2008;283:30225-34 pubmed publisher
Zanchi C, Zoja C, Morigi M, Valsecchi F, Liu X, Rottoli D, et al. Fractalkine and CX3CR1 mediate leukocyte capture by endothelium in response to Shiga toxin. J Immunol. 2008;181:1460-9 pubmed
Popovic M, Laumonnier Y, Burysek L, Syrovets T, Simmet T. Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration. J Leukoc Biol. 2008;84:215-23 pubmed publisher
You J, Yang C, Huang J, Chen M, Yang C. Fractalkine, a CX3C chemokine, as a mediator of ocular angiogenesis. Invest Ophthalmol Vis Sci. 2007;48:5290-8 pubmed
Hundhausen C, Schulte A, Schulz B, Andrzejewski M, Schwarz N, von Hundelshausen P, et al. Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes. J Immunol. 2007;178:8064-72 pubmed
Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, et al. Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J Immunol. 2004;173:6592-602 pubmed
Bolovan Fritts C, Trout R, Spector S. Human cytomegalovirus-specific CD4+-T-cell cytokine response induces fractalkine in endothelial cells. J Virol. 2004;78:13173-81 pubmed
Lavergne E, Combadiere B, Bonduelle O, Iga M, Gao J, Maho M, et al. Fractalkine mediates natural killer-dependent antitumor responses in vivo. Cancer Res. 2003;63:7468-74 pubmed
Zhang Q, Shimoya K, Ohta Y, Chin R, Tenma K, Isaka S, et al. Detection of fractalkine in human seminal plasma and its role in infertile patients. Hum Reprod. 2002;17:1560-4 pubmed

product information

brand :

R&D Systems

master code :

365-FR

SKU :

365-FR-025

product name :

Recombinant Human CX3CL1/Fractalkine (Full Length) Protein

unit size :

25 ug

seo description :

The Recombinant Human CX3CL1/Fractalkine (Full Length) Protein from R&D Systems is derived from NS0. The Recombinant Human CX3CL1/Fractalkine (Full Length) Protein has been validated for the following applications: Bioactivity.

target :

CX3CL1/Fractalkine

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

90 kDa, reducing conditions

theoretical molecular weight :

35 kDa

gene symbol :

CX3CL1

details of functionality :

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with mouse CX3CR1. The ED50 for this effect is 20-100 ng/mL. Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CX3CR1. The ED50 for this effect is 2.5-10 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P78423

applications :

Bioactivity

source :

NS0-derived Recombinant Human CX3CL1/Fractalkine (Full Length) Protein

USD :

407 USD

alt names :

ABCD-3, C3Xkine, chemokine (C-X3-C motif) ligand 1, CX3C membrane-anchored chemokine, CXC3, CXC3C, FKN, fractalkine, Neurotactin, neurotactin), NTNsmall inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, NTTSmall-inducible cytokine D1, SCYD1C-X3-C motif chemokine 1, small inducible cytokine subfamily D (Cys-X3-Cys), member-1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage