Recombinant Human Notch-1 Fc Chimera Protein, CF | R&D Systems 3647-TK product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Notch-1 Fc Chimera Protein, CF

catalog :

3647-TK

quantity :

50 ug

price :

339 USD

citations: 3

Reference
Li Y, Hickson J, Ambrosi D, Haasch D, Foster Duke K, Eaton L, et al. ABT-165, a Dual Variable Domain Immunoglobulin (DVD-Ig) Targeting DLL4 and VEGF, Demonstrates Superior Efficacy and Favorable Safety Profiles in Preclinical Models. Mol Cancer Ther. 2018;17:1039-1050 pubmed publisher
Andrawes M, Xu X, Liu H, Ficarro S, Marto J, Aster J, et al. Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. J Biol Chem. 2013;288:25477-89 pubmed publisher
Scehnet J, Jiang W, Kumar S, Krasnoperov V, Trindade A, Benedito R, et al. Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Blood. 2007;109:4753-60 pubmed

product information

brand :

R&D Systems

master code :

3647-TK

SKU :

3647-TK-050

product name :

Recombinant Human Notch-1 Fc Chimera Protein, CF

description :

The Recombinant Human Notch-1 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Notch-1 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

Notch-1

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

115-125 kDa, reducing conditions

theoretical molecular weight :

80.1 kDa (monomer)

gene symbol :

NOTCH1

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized rhNotch-1 Fc Chimera at 5 µg/mL (100 µL/well) can bind rrJagged-1/Fc Chimera with an apparent KD 5 nM in a functional ELISA.

endotoxin note :

<0.1 EU per 1 µg of the protein by the LAL method.

catalog number base :

3647-TK

accessionNumbers :

P46531

applications :

Binding Activity

source :

Mouse myeloma cell line, NS0-derived human Notch-1 protein Human Notch-1 (Ala19 - Gln526) Accession # P46531 IEGRMD Human IgG1 (Pro100 - Lys330) N-terminus C-terminus

2020 USD :

339

2021 USD :

339 USD

alt names :

EC 2.1.2.11, EC 3.4.21.68, hN1, Notch (Drosophila) homolog 1 (translocation-associated), notch 1Notch homolog 1, translocation-associated (Drosophila), Notch homolog 1, translocation-associated, Notch1, TAN1, TAN1neurogenic locus notch homolog protein 1, Translocation-associated notch protein TAN-1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.