This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-33 Protein
catalog :
3625-IL
quantity :
10 ug
price :
329 USD
citations: 41
Reference
Mishima Y, Sonoyama H, Ishihara S, Oshima N, Moriyama I, Kawashima K, et al. Interleukin-33 delays recovery of mucosal inflammation via downregulation of homeostatic ABCG5/8 in the colon. Lab Invest. 2020;100:491-502 pubmed publisher
Zhang J, Tao T, Wang K, Zhang G, Yan Y, Lin H, et al. IL-33/ST2 axis promotes glioblastoma cell invasion by accumulating tenascin-C. Sci Rep. 2019;9:20276 pubmed publisher
Sugihara S, Sugimoto S, Tachibana K, Kobashi M, Nomura H, Miyake T, et al. TNF-α and IL-17A induce the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytes. J Dermatol Sci. 2019;96:26-32 pubmed publisher
Bernink J, Ohne Y, Teunissen M, Wang J, Wu J, Krabbendam L, et al. c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies. Nat Immunol. 2019;20:992-1003 pubmed publisher
Hochdörfer T, Winkler C, Pardali K, Mjösberg J. Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells. Eur J Immunol. 2019;49:884-893 pubmed publisher
Qin X, Liu M, Zhang S, Wang C, Zhang T. The role of IL-36γ and its regulation in eosinophilic inflammation in allergic rhinitis. Cytokine. 2019;117:84-90 pubmed publisher
Matsumoto K, Kouzaki H, Kikuoka H, Kato T, Tojima I, Shimizu S, et al. Soluble ST2 suppresses IL-5 production by human basophilic KU812 cells, induced by epithelial cell-derived IL-33. Allergol Int. 2018;67S:S32-S37 pubmed publisher
Liu J, Wang W, Wang L, Chen S, Tian B, Huang K, et al. IL-33 Initiates Vascular Remodelling in Hypoxic Pulmonary Hypertension by up-Regulating HIF-1α and VEGF Expression in Vascular Endothelial Cells. EBioMedicine. 2018;33:196-210 pubmed publisher
Ryu W, Lee H, Bae H, Jeon J, Ryu H, Kim J, et al. IL-33 down-regulates CLDN1 expression through the ERK/STAT3 pathway in keratinocytes. J Dermatol Sci. 2018;90:313-322 pubmed publisher
Miao Q, Wang Y, Liu Y, Ren Y, Guan H, Li Z, et al. Seasonal variation in circulating group 2 innate lymphoid cells in mugwort-allergic asthmatics during and outside pollen season. Allergy Asthma Clin Immunol. 2018;14:6 pubmed publisher
Lopez Lastra S, Masse Ranson G, Fiquet O, Darche S, Serafini N, Li Y, et al. A functional DC cross talk promotes human ILC homeostasis in humanized mice. Blood Adv. 2017;1:601-614 pubmed publisher
Miller J, Monsanto S, Ahn S, Khalaj K, Fazleabas A, Young S, et al. Interleukin-33 modulates inflammation in endometriosis. Sci Rep. 2017;7:17903 pubmed publisher
Wang K, Shan S, Yang Z, Gu X, Wang Y, Wang C, et al. IL-33 blockade suppresses tumor growth of human lung cancer through direct and indirect pathways in a preclinical model. Oncotarget. 2017;8:68571-68582 pubmed publisher
Díaz Jiménez D, Núñez L, De la Fuente M, Dubois Camacho K, Sepulveda H, Montecino M, et al. A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis. Sci Rep. 2017;7:10180 pubmed publisher
Zhang J, Wang P, Yan Y, Li Y, Guan M, Yu J, et al. IL‑33 enhances glioma cell migration and invasion by upregulation of MMP2 and MMP9 via the ST2-NF-κB pathway. Oncol Rep. 2017;38:2033-2042 pubmed publisher
Wang X, Liu W, Fan D, Hu W, Li M, Zhu X, et al. IL‑33 restricts invasion and adhesion of trophoblast cell line JEG3 by downregulation of integrin α4β1 and CD62L. Mol Med Rep. 2017;16:3887-3893 pubmed publisher
Lombardi V, Luce S, Moussu H, Morizur L, Gueguen C, Neukirch C, et al. Effector and regulatory dendritic cells display distinct patterns of miRNA expression. Immun Inflamm Dis. 2017;5:310-317 pubmed publisher
Taracanova A, Alevizos M, Karagkouni A, Weng Z, Norwitz E, Conti P, et al. SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors. Proc Natl Acad Sci U S A. 2017;114:E4002-E4009 pubmed publisher
Fang M, Li Y, Huang K, Qi S, Zhang J, Zgodzinski W, et al. IL33 Promotes Colon Cancer Cell Stemness via JNK Activation and Macrophage Recruitment. Cancer Res. 2017;77:2735-2745 pubmed publisher
Akimoto M, Maruyama R, Takamaru H, Ochiya T, Takenaga K. Soluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment. Nat Commun. 2016;7:13589 pubmed publisher
Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Nakata T, Murano T, et al. PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells. Sci Rep. 2016;6:36795 pubmed publisher
Tsuzuki H, Arinobu Y, Miyawaki K, Takaki A, Ota S, Ota Y, et al. Functional interleukin-33 receptors are expressed in early progenitor stages of allergy-related granulocytes. Immunology. 2017;150:64-73 pubmed publisher
Stojkovic S, Kaun C, Basílio J, Rauscher S, Hell L, Krychtiuk K, et al. Tissue factor is induced by interleukin-33 in human endothelial cells: a new link between coagulation and inflammation. Sci Rep. 2016;6:25171 pubmed publisher
Bal S, Bernink J, Nagasawa M, Groot J, Shikhagaie M, Golebski K, et al. IL-1?, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs. Nat Immunol. 2016;17:636-45 pubmed publisher
Bu X, Zhang T, Wang C, Ren T, Wen Z. IL-33 reflects dynamics of disease activity in patients with autoimmune hemolytic anemia by regulating autoantibody production. J Transl Med. 2015;13:381 pubmed publisher
Kempuraj D, Thangavel R, Yang E, Pattani S, Zaheer S, Santillan D, et al. Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins α-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators. PLoS ONE. 2015;10:e0135776 pubmed publisher
Maywald R, Doerner S, Pastorelli L, De Salvo C, Benton S, Dawson E, et al. IL-33 activates tumor stroma to promote intestinal polyposis. Proc Natl Acad Sci U S A. 2015;112:E2487-96 pubmed publisher
Kim J, Lim S, Kim G, Yun H, Ahn S, Choi H. Interleukin-33/ST2 axis promotes epithelial cell transformation and breast tumorigenesis via upregulation of COT activity. Oncogene. 2015;34:4928-38 pubmed publisher
Stojkovic S, Kaun C, Heinz M, Krychtiuk K, Rauscher S, Lemberger C, et al. Interleukin-33 induces urokinase in human endothelial cells--possible impact on angiogenesis. J Thromb Haemost. 2014;12:948-57 pubmed publisher
Levescot A, Flamant S, Basbous S, Jacomet F, Feraud O, Anne Bourgeois E, et al. BCR-ABL-induced deregulation of the IL-33/ST2 pathway in CD34+ progenitors from chronic myeloid leukemia patients. Cancer Res. 2014;74:2669-76 pubmed publisher
Teunissen M, Munneke J, Bernink J, Spuls P, Res P, te Velde A, et al. Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients. J Invest Dermatol. 2014;134:2351-2360 pubmed publisher
Wong T, Doyle A, Lee J, Jelinek D. Eosinophils regulate peripheral B cell numbers in both mice and humans. J Immunol. 2014;192:3548-58 pubmed publisher
Thierry A, Giraud S, Robin A, Barra A, Bridoux F, Ameteau V, et al. The alarmin concept applied to human renal transplantation: evidence for a differential implication of HMGB1 and IL-33. PLoS ONE. 2014;9:e88742 pubmed publisher
Qiu H, Wong C, Chu I, Hu S, Lam C. Muramyl dipeptide mediated activation of human bronchial epithelial cells interacting with basophils: a novel mechanism of airway inflammation. Clin Exp Immunol. 2013;172:81-94 pubmed publisher
Liu K, Hu S, Chan B, Wat E, Lau C, Hon K, et al. Anti-inflammatory and anti-allergic activities of Pentaherb formula, Moutan Cortex (Danpi) and gallic acid. Molecules. 2013;18:2483-500 pubmed publisher
Willart M, Deswarte K, Pouliot P, Braun H, Beyaert R, Lambrecht B, et al. Interleukin-1? controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J Exp Med. 2012;209:1505-17 pubmed publisher
Sahlander K, Larsson K, Palmberg L. Daily exposure to dust alters innate immunity. PLoS ONE. 2012;7:e31646 pubmed publisher
Vasiadi M, Therianou A, Alysandratos K, Katsarou Katsari A, Petrakopoulou T, Theoharides A, et al. Serum neurotensin (NT) is increased in psoriasis and NT induces vascular endothelial growth factor release from human mast cells. Br J Dermatol. 2012;166:1349-52 pubmed publisher
Hong Y, Moon S, Joo Y, Jeon C, Cho M, Ju J, et al. Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis. J Korean Med Sci. 2011;26:1132-9 pubmed publisher
Tare N, Li H, Morschauser A, Cote Sierra J, Ju G, Renzetti L, et al. KU812 cells provide a novel in vitro model of the human IL-33/ST2L axis: functional responses and identification of signaling pathways. Exp Cell Res. 2010;316:2527-37 pubmed publisher
Cherry W, Yoon J, Bartemes K, Iijima K, Kita H. A novel IL-1 family cytokine, IL-33, potently activates human eosinophils. J Allergy Clin Immunol. 2008;121:1484-90 pubmed publisher
product information
brand :
R&D Systems
master code :
3625-IL
SKU :
3625-IL-010
product name :
Recombinant Human IL-33 Protein
description :
The Recombinant Human IL-33 Protein from R&D Systems is derived from E. coli. The Recombinant Human IL-33 Protein has been validated for the following applications: Bioactivity.
target :
IL-33
category :
Proteins and Enzymes
unit size :
10 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS, EDTA and DTT with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
theoretical molecular weight :
18 kDa
gene symbol :
IL33
details of functionality :
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 for this effect is 0.06-0.24 ng/mL. Optimal dilutions should be determined by each laboratory for each application.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
catalog number base :
3625-IL
accessionNumbers :
O95760
applications :
Bioactivity
source :
E. coli -derived human IL-33 protein Ser112-Thr270
2020 USD :
329
2021 USD :
329 USD
alt names :
C9orf26, C9orf26chromosome 9 open reading frame 26 (NF-HEV), DKFZp586H0523, DVS27, DVS27-related protein, IL1F11, IL-1F11, IL33, IL-33, interleukin 33, Interleukin-1 family member 11, interleukin-33, NFHEV, NF-HEV, NF-HEVNFEHEV, Nuclear factor from high endothelial venules, RP11-575C20.2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.