Recombinant Human CX3CL1/Fractalkine (Chemokine Domain), CF | R&D Systems 362-CX-025/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CX3CL1/Fractalkine (Chemokine Domain), CF

catalog :

362-CX-025/CF

quantity :

25 ug

price :

407 USD

more info or order :

R&D Systems product webpage

citations: 9

Reference
Collar A, Swamydas M, O Hayre M, Sajib M, Hoffman K, Singh S, et al. The homozygous CX3CR1-M280 mutation impairs human monocyte survival. JCI Insight. 2018;3: pubmed publisher
Park Y, Lee J, Kwak J, Noh K, Yim E, Kim H, et al. Fractalkine induces angiogenic potential in CX3CR1-expressing monocytes. J Leukoc Biol. 2018;103:53-66 pubmed publisher
Hermand P, Ciceron L, Pionneau C, Vaquero C, Combadiere C, Deterre P. Plasmodium falciparum proteins involved in cytoadherence of infected erythrocytes to chemokine CX3CL1. Sci Rep. 2016;6:33786 pubmed publisher
Truman L, Ford C, Pasikowska M, Pound J, Wilkinson S, Dumitriu I, et al. CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis. Blood. 2008;112:5026-36 pubmed publisher
Holmes F, Arnott N, Vanderplank P, Kerr N, Longbrake E, Popovich P, et al. Intra-neural administration of fractalkine attenuates neuropathic pain-related behaviour. J Neurochem. 2008;106:640-9 pubmed publisher
Clark A, Yip P, Grist J, Gentry C, Staniland A, Marchand F, et al. Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Proc Natl Acad Sci U S A. 2007;104:10655-60 pubmed
Deiva K, Geeraerts T, Salim H, Leclerc P, Hery C, Hugel B, et al. Fractalkine reduces N-methyl-d-aspartate-induced calcium flux and apoptosis in human neurons through extracellular signal-regulated kinase activation. Eur J Neurosci. 2004;20:3222-32 pubmed
Latchney L, Fallon M, Culp D, Gelbard H, Dewhurst S. Immunohistochemical assessment of fractalkine, inflammatory cells, and human herpesvirus 7 in human salivary glands. J Histochem Cytochem. 2004;52:671-81 pubmed
Lucas A, Chadwick N, Warren B, Jewell D, Gordon S, Powrie F, et al. The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo. Am J Pathol. 2001;158:855-66 pubmed

product information

brand :

R&D Systems

master code :

362-CX/CF

SKU :

362-CX-025/CF

product name :

Recombinant Human CX3CL1/Fractalkine (Chemokine Domain), CF

unit size :

25 ug

seo description :

The Recombinant Human CX3CL1/Fractalkine (Chemokine Domain), CF from R&D Systems is derived from E. coli. The Recombinant Human CX3CL1/Fractalkine (Chemokine Domain), CF has been validated for the following applications: Bioactivity.

target :

CX3CL1/Fractalkine

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

theoretical molecular weight :

8.5 kDa

gene symbol :

CX3CL1

details of functionality :

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with mouse CX3CR1. The ED50 for this effect is 2-10 ng/mL. Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CX3CR1. The ED50 for this effect is 0.3-1.5 ng/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q6I9S9

applications :

Bioactivity

source :

E. coli-derived Recombinant Human CX3CL1/Fractalkine (Chemokine Domain), CF

USD :

407 USD

alt names :

ABCD-3, C3Xkine, chemokine (C-X3-C motif) ligand 1, CX3C membrane-anchored chemokine, CXC3, CXC3C, FKN, fractalkine, Neurotactin, neurotactin), NTNsmall inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, NTTSmall-inducible cytokine D1, SCYD1C-X3-C motif chemokine 1, small inducible cytokine subfamily D (Cys-X3-Cys), member-1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage