Recombinant Human CCL20/MIP-3 alpha Protein | R&D Systems 360-MP product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CCL20/MIP-3 alpha Protein

catalog :

360-MP

quantity :

25 ug

price :

299 USD

citations: 20

Reference
Skovdahl H, Damas J, Granlund A, Østvik A, Doseth B, Bruland T, et al. C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor 6 (CCR6) in Human Peripheral Blood Mononuclear Cells: Dysregulated in Ulcerative Colitis and a Potential Role for CCL20 in IL-1β Release. Int J Mol Sci. 2018;19: pubmed publisher
Diao R, Cai X, Liu L, Yang L, Duan Y, Cai Z, et al. In vitro chemokine (C-C motif) receptor 6-dependent non-inflammatory chemotaxis during spermatogenesis. Biol Res. 2018;51:12 pubmed publisher
Diao R, Wang T, Fok K, Li X, Ruan Y, Yu M, et al. CCR6 is required for ligand-induced CatSper activation in human sperm. Oncotarget. 2017;8:91445-91458 pubmed publisher
Lu G, Zhang X, Shen L, Qiao Q, Li Y, Sun J, et al. CCL20 secreted from IgA1-stimulated human mesangial cells recruits inflammatory Th17 cells in IgA nephropathy. PLoS ONE. 2017;12:e0178352 pubmed publisher
Cecchinato V, Bernasconi E, Speck R, Proietti M, Sauermann U, D Agostino G, et al. Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization. J Immunol. 2017;198:184-195 pubmed
Xu Y, Gao Y, Wu D, Yu F, Zang Z, Yang L, et al. Aberrant cytokine secretion and zinc uptake in chronic cadmium-exposed lung epithelial cells. Proteomics Clin Appl. 2017;11: pubmed publisher
Yu Q, Lou X, He Y. Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway. PLoS ONE. 2015;10:e0120855 pubmed publisher
Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, et al. Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells. Invest Ophthalmol Vis Sci. 2015;56:1051-62 pubmed publisher
Du D, Liu Y, Qian H, Zhang B, Tang X, Zhang T, et al. The effects of the CCR6/CCL20 biological axis on the invasion and metastasis of hepatocellular carcinoma. Int J Mol Sci. 2014;15:6441-52 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Kim S, Lewis C, Nadel J. CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. J Immunol. 2011;186:3392-400 pubmed publisher
Shan M, Cheng H, Song L, Roberts L, Green L, Hacken Bitar J, et al. Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema. Sci Transl Med. 2009;1:4ra10 pubmed publisher
Charles J, Di Domizio J, Salameire D, Bendriss Vermare N, Aspord C, Muhammad R, et al. Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor. J Invest Dermatol. 2010;130:1646-56 pubmed publisher
Boniface K, Bak Jensen K, Li Y, Blumenschein W, McGeachy M, McClanahan T, et al. Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J Exp Med. 2009;206:535-48 pubmed publisher
Facco M, Baesso I, Miorin M, Bortoli M, Cabrelle A, Boscaro E, et al. Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis. J Leukoc Biol. 2007;82:946-55 pubmed
Lecureuil C, Combadiere B, Mazoyer E, Bonduelle O, Samri A, Autran B, et al. Trapping and apoptosis of novel subsets of memory T lymphocytes expressing CCR6 in the spleen of HIV-infected patients. Blood. 2007;109:3649-57 pubmed
Johnson L, Clasper S, Holt A, Lalor P, Baban D, Jackson D. An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium. J Exp Med. 2006;203:2763-77 pubmed
Hirahara K, Liu L, Clark R, Yamanaka K, Fuhlbrigge R, Kupper T. The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors. J Immunol. 2006;177:4488-94 pubmed
Nakayama T, Shirane J, Hieshima K, Shibano M, Watanabe M, Jin Z, et al. Novel antiviral activity of chemokines. Virology. 2006;350:484-92 pubmed
Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, et al. Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J Immunol. 2004;173:6592-602 pubmed

product information

brand :

R&D Systems

master code :

360-MP

SKU :

360-MP-025

product name :

Recombinant Human CCL20/MIP-3 alpha Protein

description :

The Recombinant Human CCL20/MIP-3 alpha Protein from R&D Systems is derived from E. coli. The Recombinant Human CCL20/MIP-3 alpha Protein has been validated for the following applications: Bioactivity.

target :

CCL20/MIP-3 alpha

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

theoretical molecular weight :

8 kDa

gene symbol :

CCL20

details of functionality :

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR6. The ED50 for this effect is 0.5-2 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

360-MP

accessionNumbers :

P78556

applications :

Bioactivity

source :

E. coli -derived human CCL20/MIP-3 alpha protein Ala27-Met96 (Asn95Asp)

2020 USD :

299

2021 USD :

299 USD

alt names :

beta chemokine exodus-1, Beta-chemokine exodus-1, CC chemokine LARC, C-C motif chemokine 20, chemokine (C-C motif) ligand 20, CKb4, exodus-1, LARC, LARCLiver and activation-regulated chemokine, MIP3 alpha, MIP-3 alpha, MIP-3a, MIP-3-alpha, MIP3AMacrophage inflammatory protein 3 alpha, SCYA20Small-inducible cytokine A20, small inducible cytokine subfamily A (Cys-Cys), member 20, ST38

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.