Recombinant Human CCL20/MIP-3 alpha Protein | R&D Systems 360-MP-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CCL20/MIP-3 alpha Protein

catalog :

360-MP-025

quantity :

25 ug

price :

361 USD

more info or order :

R&D Systems product webpage

citations: 23

Reference
Cheng Y, Acedera J, Li Y, Shieh S. A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis. Cell Death Differ. 2024;31:970-982 pubmed publisher
Esteves P, Allard B, Celle A, Dupin I, Maurat E, Ousova O, et al. Asthmatic bronchial smooth muscle increases rhinovirus replication within the bronchial epithelium. Cell Rep. 2022;38:110571 pubmed publisher
Chang K, Chen R, Wang Y, Hung L, Medeiros L, Chen Y, et al. Stem cell characteristics promote aggressiveness of diffuse large B-cell lymphoma. Sci Rep. 2020;10:21342 pubmed publisher
Nayrac M, Requena M, Loiseau C, Cazabat M, Suc B, Carrere N, et al. Th22 cells are efficiently recruited in the gut by CCL28 as an alternative to CCL20 but do not compensate for the loss of Th17 cells in treated HIV-1-infected individuals. Mucosal Immunol. 2021;14:219-228 pubmed publisher
Skovdahl H, Damas J, Granlund A, Østvik A, Doseth B, Bruland T, et al. C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor 6 (CCR6) in Human Peripheral Blood Mononuclear Cells: Dysregulated in Ulcerative Colitis and a Potential Role for CCL20 in IL-1β Release. Int J Mol Sci. 2018;19: pubmed publisher
Diao R, Wang T, Fok K, Li X, Ruan Y, Yu M, et al. CCR6 is required for ligand-induced CatSper activation in human sperm. Oncotarget. 2017;8:91445-91458 pubmed publisher
Lu G, Zhang X, Shen L, Qiao Q, Li Y, Sun J, et al. CCL20 secreted from IgA1-stimulated human mesangial cells recruits inflammatory Th17 cells in IgA nephropathy. PLoS ONE. 2017;12:e0178352 pubmed publisher
Cecchinato V, Bernasconi E, Speck R, Proietti M, Sauermann U, D Agostino G, et al. Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization. J Immunol. 2017;198:184-195 pubmed
Xu Y, Gao Y, Wu D, Yu F, Zang Z, Yang L, et al. Aberrant cytokine secretion and zinc uptake in chronic cadmium-exposed lung epithelial cells. Proteomics Clin Appl. 2017;11: pubmed publisher
Yu Q, Lou X, He Y. Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway. PLoS ONE. 2015;10:e0120855 pubmed publisher
Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, et al. Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells. Invest Ophthalmol Vis Sci. 2015;56:1051-62 pubmed publisher
Du D, Liu Y, Qian H, Zhang B, Tang X, Zhang T, et al. The effects of the CCR6/CCL20 biological axis on the invasion and metastasis of hepatocellular carcinoma. Int J Mol Sci. 2014;15:6441-52 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Kim S, Lewis C, Nadel J. CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. J Immunol. 2011;186:3392-400 pubmed publisher
Shan M, Cheng H, Song L, Roberts L, Green L, Hacken Bitar J, et al. Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema. Sci Transl Med. 2009;1:4ra10 pubmed publisher
Charles J, Di Domizio J, Salameire D, Bendriss Vermare N, Aspord C, Muhammad R, et al. Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor. J Invest Dermatol. 2010;130:1646-56 pubmed publisher
Boniface K, Bak Jensen K, Li Y, Blumenschein W, McGeachy M, McClanahan T, et al. Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J Exp Med. 2009;206:535-48 pubmed publisher
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product information

brand :

R&D Systems

master code :

360-MP

SKU :

360-MP-025

product name :

Recombinant Human CCL20/MIP-3 alpha Protein

unit size :

25 ug

seo description :

The Recombinant Human CCL20/MIP-3 alpha Protein from R&D Systems is derived from E. coli. The Recombinant Human CCL20/MIP-3 alpha Protein has been validated for the following applications: Bioactivity.

target :

CCL20/MIP-3 alpha

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

theoretical molecular weight :

8 kDa

gene symbol :

CCL20

details of functionality :

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR6. The ED50 for this effect is 0.5-2áng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Human CCL20/MIP-3 alpha Protein Bioactivity

accessionNumbers :

P78556

applications :

Bioactivity

source :

E. coli-derived Recombinant Human CCL20/MIP-3 alpha Protein

USD :

361 USD

alt names :

beta chemokine exodus-1, Beta-chemokine exodus-1, CC chemokine LARC, C-C motif chemokine 20, chemokine (C-C motif) ligand 20, CKb4, exodus-1, LARC, LARCLiver and activation-regulated chemokine, MIP3 alpha, MIP-3 alpha, MIP-3a, MIP-3-alpha, MIP3AMacrophage inflammatory protein 3 alpha, SCYA20Small-inducible cytokine A20, small inducible cytokine subfamily A (Cys-Cys), member 20, ST38

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage