Recombinant Human Ephrin-A3 Fc Chimera Protein, CF | R&D Systems 359-EA-200 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Ephrin-A3 Fc Chimera Protein, CF

catalog :

359-EA-200

quantity :

200 ug

price :

359 USD

citations: 10

Reference
Chen Y, Yen Y, Jang C, Wang S, Huang H, Chen C, et al. Ephrin A4-ephrin receptor A10 signaling promotes cell migration and spheroid formation by upregulating NANOG expression in oral squamous cell carcinoma cells. Sci Rep. 2021;11:644 pubmed publisher
Laing E, Navaratnarajah C, Cheliout Da Silva S, Petzing S, Xu Y, Sterling S, et al. Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus. Proc Natl Acad Sci U S A. 2019;116:20707-20715 pubmed publisher
Sharonov G, Bocharov E, Kolosov P, Astapova M, Arseniev A, Feofanov A. Point mutations in dimerization motifs of the transmembrane domain stabilize active or inactive state of the EphA2 receptor tyrosine kinase. J Biol Chem. 2014;289:14955-64 pubmed publisher
Falivelli G, Lisabeth E, Rubio de la Torre E, Pérez Tenorio G, Tosato G, Salvucci O, et al. Attenuation of eph receptor kinase activation in cancer cells by coexpressed ephrin ligands. PLoS ONE. 2013;8:e81445 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Afshari F, Kwok J, Fawcett J. Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling. J Neurosci. 2010;30:4246-55 pubmed publisher
Inoue E, Deguchi Tawarada M, Togawa A, Matsui C, Arita K, Katahira Tayama S, et al. Synaptic activity prompts gamma-secretase-mediated cleavage of EphA4 and dendritic spine formation. J Cell Biol. 2009;185:551-64 pubmed publisher
Nestor M, Mok L, Tulapurkar M, Thompson S. Plasticity of neuron-glial interactions mediated by astrocytic EphARs. J Neurosci. 2007;27:12817-28 pubmed
Sharfe N, Freywald A, Toro A, Dadi H, Roifman C. Ephrin stimulation modulates T cell chemotaxis. Eur J Immunol. 2002;32:3745-55 pubmed
Murai K, Nguyen L, Irie F, Yamaguchi Y, Pasquale E. Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nat Neurosci. 2003;6:153-60 pubmed

product information

master code :

359-EA

SKU :

359-EA-200

product name :

Recombinant Human Ephrin-A3 Fc Chimera Protein, CF

unit size :

200 ug

description :

The Recombinant Human Ephrin-A3 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Ephrin-A3 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

Ephrin-A3

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

60-70 kDa, reducing conditions

theoretical molecular weight :

47.7 kDa (monomer)

gene symbol :

EFNA3

details of functionality :

Measured by its ability to compete with Biotinylated Recombinant Human Ephrin-A3 Fc Chimera (Catalog # BT359 ) for binding to immobilized recombinant mouse Eph-A6 Fc Chimera in a functional ELISA. Optimal dilutions should be determined by each laboratory for each application.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAA52368

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived human Ephrin-A3 protein Human Ephrin-A3 (Asn31-Ser209) Accession # AAA52368 IEGRMD Human IgG1 (Pro100-Lys330) 6-His tag N-terminus C-terminus

source short :

NS0

USD :

359 USD

alt names :

EFL2, EFL-2, EFNA3, Ehk1-L, EPH-related receptor tyrosine kinase ligand 3, ephrin-A3, EphrinA3, EPLG3EHK1 ligand, LERK3, LERK3LERK-3, ligand of eph-related kinase 3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.