Recombinant Human Cyclophilin A Protein, CF | R&D Systems 3589-CAB-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Cyclophilin A Protein, CF

catalog :

3589-CAB-100

quantity :

100 ug

price :

386 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Bernal G, Wu L, Voce D, Weichselbaum R, Yamini B. p52 signaling promotes cellular senescence. Cell Biosci. 2022;12:43 pubmed publisher
Rosa A, Butt E, Hopper C, Loroch S, Bender M, Schulze H, et al. Cyclophilin A Is Not Acetylated at Lysine-82 and Lysine-125 in Resting and Stimulated Platelets. Int J Mol Sci. 2022;23: pubmed publisher
Desmarais F, Hervé V, Bergeron K, Ravaut G, Perrotte M, Fyfe Desmarais G, et al. Cerebral Apolipoprotein D Exits the Brain and Accumulates in Peripheral Tissues. Int J Mol Sci. 2021;22: pubmed publisher
Montagne A, Nation D, Sagare A, Barisano G, Sweeney M, Chakhoyan A, et al. APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. Nature. 2020;581:71-76 pubmed publisher
Biswas B, Batista F, Sundaram S, Stanley P. MGAT1 and Complex N-Glycans Regulate ERK Signaling During Spermatogenesis. Sci Rep. 2018;8:2022 pubmed publisher
Ramachandran S, Vinitha A, Kartha C. Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus. Cardiovasc Diabetol. 2016;15:152 pubmed
Heinzmann D, Bangert A, MÃ¼ller A, von Ungern Sternberg S, Emschermann F, SchÃ¶nberger T, et al. The Novel Extracellular Cyclophilin A (CyPA) - Inhibitor MM284 Reduces Myocardial Inflammation and Remodeling in a Mouse Model of Troponin I -Induced Myocarditis. PLoS ONE. 2015;10:e0124606 pubmed publisher
Seizer P, Schonberger T, Schött M, Lang M, Langer H, Bigalke B, et al. EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation. Atherosclerosis. 2010;209:51-7 pubmed publisher

product information

brand :

R&D Systems

master code :

3589-CAB

SKU :

3589-CAB-100

product name :

Recombinant Human Cyclophilin A Protein, CF

unit size :

100 ug

seo description :

The Recombinant Human Cyclophilin A Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Cyclophilin A Protein, CF has been validated for the following applications: Enzyme Activity.

target :

Cyclophilin A

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in MES and NaCl.

conjugate :

Unconjugated

dilution :

Enzyme Activity

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

17 kDa, reducing conditions

theoretical molecular weight :

18 kDa

details of functionality :

Measured by its ability to inhibit calcineurin phosphatase activity in the presence of Cyclosporin A. The IC50 for inhibition of calcineurin activity is 700 nM, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P62937

applications :

Enzyme Activity

source :

E. coli-derived Recombinant Human Cyclophilin A Protein, CF

USD :

386 USD

alt names :

Cyclophilin A, Cyclosporin A-binding protein, CYPA, CYPAMGC12404, CYPH, EC 5.2.1.8, MGC117158, MGC23397, peptidyl-prolyl cis-trans isomerase A, peptidylprolyl isomerase A (cyclophilin A), PPIA, PPIase A, Rotamase, Rotamase A, T cell cyclophilin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.

more info or order :

R&D Systems product webpage