Recombinant Human HGFR/c-MET Fc Chimera His-tag Protein | R&D Systems 358-MT product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human HGFR/c-MET Fc Chimera His-tag Protein

catalog :

358-MT

quantity :

100 ug

price :

359 USD

citations: 6

Reference
Miao W, Sakai K, Ozawa N, Nishiuchi T, Suzuki Y, Ito K, et al. Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist. Sci Rep. 2018;8:16492 pubmed publisher
Kaye D, Pinto P, Cecchi F, Reilly J, Semerjian A, Rabe D, et al. Tumor and Plasma Met Levels in Non-Metastatic Prostate Cancer. PLoS ONE. 2016;11:e0157130 pubmed publisher
Moores S, Chiu M, Bushey B, Chevalier K, Luistro L, Dorn K, et al. A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor-Resistant Lung Tumors. Cancer Res. 2016;76:3942-53 pubmed publisher
Liu L, Zeng W, Wortinger M, Yan S, Cornwell P, Peek V, et al. LY2875358, a neutralizing and internalizing anti-MET bivalent antibody, inhibits HGF-dependent and HGF-independent MET activation and tumor growth. Clin Cancer Res. 2014;20:6059-70 pubmed publisher
Tabernero J, Elez M, Herranz M, Rico I, Prudkin L, Andreu J, et al. A pharmacodynamic/pharmacokinetic study of ficlatuzumab in patients with advanced solid tumors and liver metastases. Clin Cancer Res. 2014;20:2793-804 pubmed publisher
Boltz A, Piater B, Toleikis L, Guenther R, Kolmar H, Hock B. Bi-specific aptamers mediating tumor cell lysis. J Biol Chem. 2011;286:21896-905 pubmed publisher

product information

brand :

R&D Systems

master code :

358-MT

SKU :

358-MT-100

product name :

Recombinant Human HGFR/c-MET Fc Chimera His-tag Protein

description :

The Recombinant Human HGFR/c-MET Fc Chimera His-tag Protein from R&D Systems is derived from NS0. The Recombinant Human HGFR/c-MET Fc Chimera His-tag Protein has been validated for the following applications: Binding Activity.

target :

HGFR/c-MET

category :

Proteins and Enzymes

unit size :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

43-50 kDa (alpha chain) and 120-125 kDa (beta chain), reducing conditions

theoretical molecular weight :

32.5 kDa (alpha chain), 96.7 kDa (beta chain)

gene symbol :

MET

details of functionality :

Measured by its ability to bind rhHGF in a functional ELISA with an estimated Kd 0.5 nM.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

358-MT

accessionNumbers :

P08581

applications :

Binding Activity

source :

Mouse myeloma cell line, NS0-derived human HGF R/c-MET protein HGF R alpha (Glu25-Arg307) Accession # P08581 HGF R beta (Ser308-Thr932) Accession # P08581 HIEGRMD Human IgG1 (Pro100-Lys330) 6 His tag N-terminus C-terminus

2020 USD :

359

2021 USD :

359 USD

alt names :

AUTS9, c-Met, cMET, EC 2.7.10, EC 2.7.10.1, hepatocyte growth factor receptor, HGF R, HGF receptor, HGF/SF receptor, HGFR, MET, Met (c-Met), met proto-oncogene (hepatocyte growth factor receptor), met proto-oncogene tyrosine kinase, oncogene MET, Proto-oncogene c-Met, RCCP2, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.