product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human/Mouse/Rat BMP-2 Protein
catalog :
355-BM-010
quantity :
10 ug (also 50 ug, 100 ug)
price :
416 USD
more info or order :
citations: 177
Reference
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Vora M, Mondal A, Jia D, Gaddipati P, Akel M, Gilleran J, et al. Bone morphogenetic protein signaling regulation of AMPK and PI3K in lung cancer cells and C. elegans. Cell Biosci. 2022;12:76 pubmed publisher
Leinroth A, Mirando A, Rouse D, Kobayahsi Y, Tata P, Rueckert H, et al. Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations. Cell Rep. 2022;39:110785 pubmed publisher
Kawecki F, Jann J, Fortin M, Auger F, Faucheux N, Fradette J. Preclinical Evaluation of BMP-9-Treated Human Bone-like Substitutes for Alveolar Ridge Preservation following Tooth Extraction. Int J Mol Sci. 2022;23: pubmed publisher
Nagel S, Pommerenke C, Meyer C, MacLeod R. The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia. Int J Mol Sci. 2022;23: pubmed publisher
López Antona I, Contreras Jurado C, Luque Martín L, Carpintero Leyva A, González Méndez P, Palmero I. Dynamic regulation of myofibroblast phenotype in cellular senescence. Aging Cell. 2022;21:e13580 pubmed publisher
Moncayo Donoso M, Rico Llanos G, Garzón Alvarado D, Becerra J, Visser R, Fontanilla M. The Effect of Pore Directionality of Collagen Scaffolds on Cell Differentiation and In Vivo Osteogenesis. Polymers (Basel). 2021;13: pubmed publisher
Zheng M, Erhardt S, Ai D, Wang J. Bmp Signaling Regulates Hand1 in a Dose-Dependent Manner during Heart Development. Int J Mol Sci. 2021;22: pubmed publisher
Gajjala P, Kasam R, Soundararajan D, Sinner D, Huang S, Jegga A, et al. Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis. JCI Insight. 2021;6: pubmed publisher
Briquez P, Tsai H, Watkins E, Hubbell J. Engineered bridge protein with dual affinity for bone morphogenetic protein-2 and collagen enhances bone regeneration for spinal fusion. Sci Adv. 2021;7: pubmed publisher
Cheung V, Peng C, Marini x107 M, Sakabe N, Aneas I, Lynch V, et al. Pluripotent stem cell-derived endometrial stromal fibroblasts in a cyclic, hormone-responsive, coculture model of human decidua. Cell Rep. 2021;35:109138 pubmed publisher
Zhou C, Chen D, Ren J, Huang D, Li R, Luo H, et al. FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex. J Cell Mol Med. 2021;: pubmed publisher
Hiraoka K, Inada H, Yanai K, Osumi N. Bone Morphogenetic Proteins Inhibit Ciliogenesis of Ependymal Cells in Vitro. Tohoku J Exp Med. 2020;252:199-208 pubmed publisher
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Leiendecker L, Jung P, Kręcioch I, Neumann T, Schleiffer A, Mechtler K, et al. LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma. EMBO Mol Med. 2020;12:e12525 pubmed publisher
Mang T, Kleinschmidt Doerr K, Ploeger F, Schoenemann A, Lindemann S, Gigout A. BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation. J Cell Sci. 2020;133: pubmed publisher
Meurer S, Tezcan O, Lammers T, Weiskirchen R. Differential regulation of Lipocalin 2 (LCN2) in doxorubicin-resistant 4T1 triple negative breast cancer cells. Cell Signal. 2020;74:109731 pubmed publisher
Meng L, Teng X, Liu Y, Yang C, Wang S, Yuan W, et al. Vital Roles of Gremlin-1 in Pulmonary Arterial Hypertension Induced by Systemic-to-Pulmonary Shunts. J Am Heart Assoc. 2020;9:e016586 pubmed publisher
Ibrahim A, Hussein K, Wang F, Wan M, Saad N, Essa M, et al. Bone Morphogenetic Protein (BMP)4 But Not BMP2 Disrupts the Barrier Integrity of Retinal Pigment Epithelia and Induces Their Migration: A Potential Role in Neovascular Age-Related Macular Degeneration. J Clin Med. 2020;9: pubmed publisher
VanCleave A, Palmer M, Fang F, Torres H, Rodezno T, Li Q, et al. Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway. Oncotarget. 2020;11:2597-2610 pubmed publisher
Qin S, Wang W, Liu Z, Hua X, Fu S, Dong F, et al. Fibrochondrogenic differentiation potential of tendon-derived stem/progenitor cells from human patellar tendon. J Orthop Translat. 2020;22:101-108 pubmed publisher
Dudakovic A, Samsonraj R, Paradise C, Galeano Garces C, Mol M, Galeano Garces D, et al. Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2. J Biol Chem. 2020;295:7877-7893 pubmed publisher
Krouwels A, Iljas J, Kragten A, Dhert W, Oner F, Tryfonidou M, et al. Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration. Int J Mol Sci. 2020;21: pubmed publisher
Stich S, Jagielski M, Fleischmann A, Meier C, Bussmann P, Kohl B, et al. Degeneration of Lumbar Intervertebral Discs: Characterization of Anulus Fibrosus Tissue and Cells of Different Degeneration Grades. Int J Mol Sci. 2020;21: pubmed publisher
Mázala D, Novak J, Hogarth M, Nearing M, Adusumalli P, Tully C, et al. TGF-β-driven muscle degeneration and failed regeneration underlie disease onset in a DMD mouse model. JCI Insight. 2020;5: pubmed publisher
Castro Viñuelas R, Sanjurjo Rodríguez C, Piñeiro Ramil M, Hermida Gómez T, Rodríguez Fernández S, Oreiro N, et al. Generation and characterization of human induced pluripotent stem cells (iPSCs) from hand osteoarthritis patient-derived fibroblasts. Sci Rep. 2020;10:4272 pubmed publisher
Broekelmann T, Bodmer N, Mecham R. Identification of the growth factor-binding sequence in the extracellular matrix protein MAGP-1. J Biol Chem. 2020;295:2687-2697 pubmed publisher
Zhao H, Chang H, Klausen C, Zhu H, Li Y, Leung P. Bone morphogenetic protein 2 induces the activation of WNT/β-catenin signaling and human trophoblast invasion through up-regulating BAMBI. Cell Signal. 2020;67:109489 pubmed publisher
Seo D, Jung S, Park J, Lee J, Ha J, Kim M, et al. The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway. EBioMedicine. 2019;49:55-71 pubmed publisher
Omi M, Kaartinen V, Mishina Y. Activin A receptor type 1-mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD-signaling pathway. J Biol Chem. 2019;294:17818-17836 pubmed publisher
Dutton L, O Neill C, Medina R, Brazil D. No evidence of Gremlin1-mediated activation of VEGFR2 signaling in endothelial cells. J Biol Chem. 2019;294:18041-18045 pubmed publisher
Ren J, Smid M, Iaria J, Salvatori D, van Dam H, Zhu H, et al. Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression. Breast Cancer Res. 2019;21:109 pubmed publisher
Li L, Jiang Y, Lin H, Shen H, Sohn J, Alexander P, et al. Muscle injury promotes heterotopic ossification by stimulating local bone morphogenetic protein-7 production. J Orthop Translat. 2019;18:142-153 pubmed publisher
Krüger K, Schmid S, Paulsen F, Ignatius A, Klinger P, Hotfiel T, et al. Trefoil Factor 3 (TFF3) Is Involved in Cell Migration for Skeletal Repair. Int J Mol Sci. 2019;20: pubmed publisher
Moghadasi Boroujeni S, KOONTZ A, Tseropoulos G, Kerosuo L, Mehrotra P, Bajpai V, et al. Neural crest stem cells from human epidermis of aged donors maintain their multipotency in vitro and in vivo. Sci Rep. 2019;9:9750 pubmed publisher
Li J, Ayoub A, Xiu Y, Yin X, Sanders J, Mesfin A, et al. TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis. Nat Commun. 2019;10:2795 pubmed publisher
Rosina M, Langone F, Giuliani G, Cerquone Perpetuini A, Reggio A, Calderone A, et al. Osteogenic differentiation of skeletal muscle progenitor cells is activated by the DNA damage response. Sci Rep. 2019;9:5447 pubmed publisher
Zhang X, Lin X, Liu T, Deng L, Huang Y, Liu Y. Osteogenic Enhancement Between Icariin and Bone Morphogenetic Protein 2: A Potential Osteogenic Compound for Bone Tissue Engineering. Front Pharmacol. 2019;10:201 pubmed publisher
Kim H, Kim H, Choi Y, Bae M, Hwang D, Shin S, et al. Zoledronate Enhances Osteocyte-Mediated Osteoclast Differentiation by IL-6/RANKL Axis. Int J Mol Sci. 2019;20: pubmed publisher
Supakul S, Yao K, Ochi H, Shimada T, Hashimoto K, Sunamura S, et al. Pericytes as a Source of Osteogenic Cells in Bone Fracture Healing. Int J Mol Sci. 2019;20: pubmed publisher
Ho W, Freem L, Zhao D, Painter K, Woolley T, Gaffney E, et al. Feather arrays are patterned by interacting signalling and cell density waves. PLoS Biol. 2019;17:e3000132 pubmed publisher
Yu L, Dawson L, Yan M, Zimmel K, Lin Y, Dolan C, et al. BMP9 stimulates joint regeneration at digit amputation wounds in mice. Nat Commun. 2019;10:424 pubmed publisher
Karakida T, Onuma K, Saito M, Yamamoto R, Chiba T, Chiba R, et al. Potential for Drug Repositioning of Midazolam for Dentin Regeneration. Int J Mol Sci. 2019;20: pubmed publisher
Hendrikx S, Coso S, Prat Luri B, Wetterwald L, Sabine A, Franco C, et al. Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2. Cell Rep. 2019;26:1227-1241.e6 pubmed publisher
Addison W, Hall K, Kokabu S, Matsubara T, Fu M, Gori F, et al. Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation. Mol Cell Biol. 2019;39: pubmed publisher
Subileau M, Merdzhanova G, Ciais D, Collin Faure V, Feige J, Bailly S, et al. Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation. Stem Cell Reports. 2019;12:98-111 pubmed publisher
Wang B, Guo Y, Chen X, Zeng C, Hu Q, Yin W, et al. Nanoparticle-modified chitosan-agarose-gelatin scaffold for sustained release of SDF-1 and BMP-2. Int J Nanomedicine. 2018;13:7395-7408 pubmed publisher
Oudina K, Paquet J, Moya A, Massouridès E, Bensidhoum M, Larochette N, et al. The paracrine effects of human induced pluripotent stem cells promote bone-like structures via the upregulation of BMP expression in a mouse ectopic model. Sci Rep. 2018;8:17106 pubmed publisher
Lee S, Abel E, Long F. Glucose metabolism induced by Bmp signaling is essential for murine skeletal development. Nat Commun. 2018;9:4831 pubmed publisher
Pane L, Fulcoli F, Cirino A, Altomonte A, Ferrentino R, Bilio M, et al. Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer. Dis Model Mech. 2018;11: pubmed publisher
Sasa K, Yoshimura K, Yamada A, Suzuki D, Miyamoto Y, Imai H, et al. Monocarboxylate transporter-1 promotes osteoblast differentiation via suppression of p53, a negative regulator of osteoblast differentiation. Sci Rep. 2018;8:10579 pubmed publisher
Koefoed K, Skat Rørdam J, Andersen P, Warzecha C, Pye M, Andersen T, et al. The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development. Sci Rep. 2018;8:9542 pubmed publisher
Chung Y, Huang Y, Chu T, Chen C, Lin P, Huang S, et al. BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-β1 signaling. Lab Invest. 2018;98:999-1013 pubmed publisher
Jongwattanapisan P, Terajima M, Miguez P, Querido W, Nagaoka H, Sumida N, et al. Identification of the effector domain of biglycan that facilitates BMP-2 osteogenic function. Sci Rep. 2018;8:7022 pubmed publisher
Kang H, Jha S, Deng Z, Fratzl Zelman N, Cabral W, Ivovic A, et al. Somatic activating mutations in MAP2K1 cause melorheostosis. Nat Commun. 2018;9:1390 pubmed publisher
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Burmeister D, Stone R, Wrice N, Laborde A, Becerra S, Natesan S, et al. Delivery of Allogeneic Adipose Stem Cells in Polyethylene Glycol-Fibrin Hydrogels as an Adjunct to Meshed Autografts After Sharp Debridement of Deep Partial Thickness Burns. Stem Cells Transl Med. 2018;7:360-372 pubmed publisher
Desancé M, Contentin R, Bertoni L, Gómez Leduc T, Branly T, Jacquet S, et al. Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy. Int J Mol Sci. 2018;19: pubmed publisher
Kokabu S, Rosen V. BMP3 expression by osteoblast lineage cells is regulated by canonical Wnt signaling. FEBS Open Bio. 2018;8:168-176 pubmed publisher
Lees Shepard J, Yamamoto M, Biswas A, Stoessel S, Nicholas S, Cogswell C, et al. Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva. Nat Commun. 2018;9:471 pubmed publisher
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Youngstrom D, Senos R, Zondervan R, Brodeur J, Lints A, Young D, et al. Intraoperative delivery of the Notch ligand Jagged-1 regenerates appendicular and craniofacial bone defects. NPJ Regen Med. 2017;2:32 pubmed publisher
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Yu Y, Gu S, Li W, Sun C, Chen F, Xiao M, et al. Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-? signaling. Proc Natl Acad Sci U S A. 2017;114:10113-10118 pubmed publisher
Bae S, Kim H, Won H, Min Y, Hwang E. Acceleration of osteoblast differentiation by a novel osteogenic compound, DMP-PYT, through activation of both the BMP and Wnt pathways. Sci Rep. 2017;7:8455 pubmed publisher
Fan J, Pi Anfruns J, Guo M, Im D, Cui Z, Kim S, et al. Small molecule-mediated tribbles homolog 3 promotes bone formation induced by bone morphogenetic protein-2. Sci Rep. 2017;7:7518 pubmed publisher
Sallon C, Callebaut I, Boulay I, Fontaine J, Logeart Avramoglou D, Henriquet C, et al. Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells. J Biol Chem. 2017;292:15352-15368 pubmed publisher
Francois S, Eder V, Belmokhtar K, Machet M, Douay L, Gorin N, et al. Synergistic effect of human Bone Morphogenic Protein-2 and Mesenchymal Stromal Cells on chronic wounds through hypoxia-inducible factor-1 α induction. Sci Rep. 2017;7:4272 pubmed publisher
Múnera J, Sundaram N, Rankin S, Hill D, Watson C, Mahe M, et al. Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling. Cell Stem Cell. 2017;21:51-64.e6 pubmed publisher
Bai L, Chang H, Cheng J, Klausen C, Chu G, Leung P, et al. SMAD1/5 mediates bone morphogenetic protein 2-induced up-regulation of BAMBI expression in human granulosa-lutein cells. Cell Signal. 2017;37:52-61 pubmed publisher
Feng J, Jing J, Li J, Zhao H, Punj V, Zhang T, et al. BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice. Development. 2017;144:2560-2569 pubmed publisher
Lin Y, Lee J, Lim J, Choolani M, Chan J, Reuveny S, et al. Critical attributes of human early mesenchymal stromal cell-laden microcarrier constructs for improved chondrogenic differentiation. Stem Cell Res Ther. 2017;8:93 pubmed publisher
Bae S, Min Y, Hwang E. Potent osteogenic activity of a novel imidazobenzimidazole derivative, IBIP. Biochem Biophys Res Commun. 2017;487:409-414 pubmed publisher
Breitkopf Heinlein K, Meyer C, König C, Gaitantzi H, Addante A, Thomas M, et al. BMP-9 interferes with liver regeneration and promotes liver fibrosis. Gut. 2017;66:939-954 pubmed publisher
Hammers D, Merscham Banda M, Hsiao J, ENGST S, Hartman J, Sweeney H. Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med. 2017;9:531-544 pubmed publisher
Veraitch O, Mabuchi Y, Matsuzaki Y, Sasaki T, Okuno H, Tsukashima A, et al. Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells. Sci Rep. 2017;7:42777 pubmed publisher
Stevens M, Chaturvedi P, Rankin S, MacDonald M, Jagannathan S, Yukawa M, et al. Genomic integration of Wnt/β-catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional programs. Development. 2017;144:1283-1295 pubmed publisher
Riba A, Emmenlauer M, Chen A, Sigoillot F, Cong F, Dehio C, et al. Explicit Modeling of siRNA-Dependent On- and Off-Target Repression Improves the Interpretation of Screening Results. Cell Syst. 2017;4:182-193.e4 pubmed publisher
Jung T, Lee J, Park S, Kim Y, Seo J, Shim H, et al. Effect of BMP-2 Delivery Mode on Osteogenic Differentiation of Stem Cells. Stem Cells Int. 2017;2017:7859184 pubmed publisher
Hegarty S, Sullivan A, O Keeffe G. Endocytosis contributes to BMP2-induced Smad signalling and neuronal growth. Neurosci Lett. 2017;643:32-37 pubmed publisher
Sripathy S, Leko V, Adrianse R, Loe T, Foss E, Dalrymple E, et al. Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression. Proc Natl Acad Sci U S A. 2017;114:1619-1624 pubmed publisher
Tevlek A, Hosseinian P, Ogutcu C, Turk M, Aydin H. Bi-layered constructs of poly(glycerol-sebacate)-β-tricalcium phosphate for bone-soft tissue interface applications. Mater Sci Eng C Mater Biol Appl. 2017;72:316-324 pubmed publisher
Wu Y, Chang H, Huang H, Sheng J, Leung P. Bone morphogenetic protein 2 regulates cell-cell communication by down-regulating connexin43 expression in luteinized human granulosa cells. Mol Hum Reprod. 2017;23:155-165 pubmed publisher
Yu Z, Mouillesseaux K, Kushner E, Bautch V. Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication. PLoS ONE. 2016;11:e0168334 pubmed publisher
de Souza G, Costa J, da Cunha E, Passos J, Ribeiro R, Saraiva M, et al. Bovine ovarian stem cells differentiate into germ cells and oocyte-like structures after culture in vitro. Reprod Domest Anim. 2017;52:243-250 pubmed publisher
Kanamori Y, Sugiyama M, Hashimoto O, Murakami M, Matsui T, Funaba M. Regulation of hepcidin expression by inflammation-induced activin B. Sci Rep. 2016;6:38702 pubmed publisher
Mouillesseaux K, Wiley D, Saunders L, Wylie L, Kushner E, Chong D, et al. Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6. Nat Commun. 2016;7:13247 pubmed publisher
Hiranuma K, Yamada A, Kurosawa T, Aizawa R, Suzuki D, Saito Y, et al. Expression of nephronectin is enhanced by 1α,25-dihydroxyvitamin D3. FEBS Open Bio. 2016;6:914-8 pubmed publisher
Blashki D, Murphy M, Ferrari M, Simmons P, Tasciotti E. Mesenchymal stem cells from cortical bone demonstrate increased clonal incidence, potency, and developmental capacity compared to their bone marrow-derived counterparts. J Tissue Eng. 2016;7:2041731416661196 pubmed publisher
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Karner C, Esen E, Chen J, Hsu F, Turk J, Long F. Wnt Protein Signaling Reduces Nuclear Acetyl-CoA Levels to Suppress Gene Expression during Osteoblast Differentiation. J Biol Chem. 2016;291:13028-39 pubmed publisher
Chang C, Yeh S, Lee B, Chen C, Su C, Lin Y, et al. Osteogenic Surface Modification Based on Functionalized Poly-P-Xylylene Coating. PLoS ONE. 2015;10:e0137017 pubmed publisher
Cruet Hennequart S, Drougard C, Shaw G, Legendre F, Demoor M, Barry F, et al. Radiation-induced alterations of osteogenic and chondrogenic differentiation of human mesenchymal stem cells. PLoS ONE. 2015;10:e0119334 pubmed publisher
Westhrin M, Xie M, Olderøy M, Sikorski P, Strand B, Standal T. Osteogenic differentiation of human mesenchymal stem cells in mineralized alginate matrices. PLoS ONE. 2015;10:e0120374 pubmed publisher
Nio Kobayashi J, Trendell J, Giakoumelou S, Boswell L, Nicol L, Kudo M, et al. Bone morphogenetic proteins are mediators of luteolysis in the human corpus luteum. Endocrinology. 2015;156:1494-503 pubmed publisher
Malhotra R, Burke M, Martyn T, Shakartzi H, Thayer T, O Rourke C, et al. Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency. PLoS ONE. 2015;10:e0117098 pubmed publisher
Prewitt A, Ghose S, Frump A, Datta A, Austin E, Kenworthy A, et al. Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertension. J Biol Chem. 2015;290:960-71 pubmed publisher
Hill C, Jacobs B, Brown C, Barnett J, Goudy S. Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis. Dev Dyn. 2015;244:122-33 pubmed publisher
Yang X, Trehan S, Guan Y, Sun C, Moore D, Jayasuriya C, et al. Matrilin-3 inhibits chondrocyte hypertrophy as a bone morphogenetic protein-2 antagonist. J Biol Chem. 2014;289:34768-79 pubmed publisher
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Gao X, Cao Y, Staloch D, Gonzales M, Aronson J, Chao C, et al. Bone morphogenetic protein signaling protects against cerulein-induced pancreatic fibrosis. PLoS ONE. 2014;9:e89114 pubmed publisher
Wolf S, Hagl B, Kappler R. Identification of BMP2 as an epigenetically silenced growth inhibitor in rhabdomyosarcoma. Int J Oncol. 2014;44:1727-35 pubmed publisher
Suresh Babu S, Valdez Y, Xu A, O Byrne A, Calvo F, Lei V, et al. TGF?-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells. BMC Cancer. 2014;14:113 pubmed publisher
Ratnayake M, Plöger F, Santibanez Koref M, Loughlin J. Human chondrocytes respond discordantly to the protein encoded by the osteoarthritis susceptibility gene GDF5. PLoS ONE. 2014;9:e86590 pubmed publisher
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Garrel G, Simon V, Denoyelle C, Ishaq M, Rouch C, Dairou J, et al. Unsaturated fatty acids disrupt Smad signaling in gonadotrope cells leading to inhibition of FSHβ gene expression. Endocrinology. 2014;155:592-604 pubmed publisher
Clementi C, Tripurani S, Large M, Edson M, Creighton C, Hawkins S, et al. Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans. PLoS Genet. 2013;9:e1003863 pubmed publisher
Brady K, Dickinson S, Guillot P, Polak J, Blom A, Kafienah W, et al. Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis. Stem Cells Dev. 2014;23:541-54 pubmed publisher
Gao L, Sheu T, Dong Y, Hoak D, Zuscik M, Schwarz E, et al. TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. J Cell Sci. 2013;126:5704-13 pubmed publisher
Kawamoto T, Kobayashi Y, Nakajima H, Yamagishi Y. Generation of robust vascular networks from cardiovascular blast populations derived from human induced pluripotent stem cells in vivo and ex vivo organ culture system. Biochem Biophys Res Commun. 2013;441:180-5 pubmed publisher
Laperrousaz B, Jeanpierre S, Sagorny K, Voeltzel T, Ramas S, Kaniewski B, et al. Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression. Blood. 2013;122:3767-77 pubmed publisher
Aubert Foucher E, Mayer N, Pasdeloup M, Pagnon A, Hartmann D, Mallein Gerin F. A unique tool to selectively detect the chondrogenic IIB form of human type II procollagen protein. Matrix Biol. 2014;34:80-8 pubmed publisher
Hwang J, Jiang T, Kulkarni S, Faure N, Schaffhausen B. Protein phosphatase 2A isoforms utilizing A? scaffolds regulate differentiation through control of Akt protein. J Biol Chem. 2013;288:32064-73 pubmed publisher
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image
image 1 :
R&D Systems 355-BM-010 image 1
Graph showing dose-dependent bioactivity of Human BMP-2 protein
product information
brand :
R&D Systems
master code :
355-BM
SKU :
355-BM-010
product name :
Recombinant Human/Mouse/Rat BMP-2 Protein
description :
The Recombinant Human/Mouse/Rat BMP-2 Protein from R&D Systems is derived from CHO. The Recombinant Human/Mouse/Rat BMP-2 Protein has been validated for the following applications: Bioactivity.
target :
BMP-2
category :
Proteins and Enzymes
unit sizes :
10 ug (also 50 ug, 100 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in Glycine, Sucrose, Tween® 80 and Glutamic Acid with BSA as a carrier protein. *1 mg pack size (01M) is supplied as a 0.2 µm filtered solution in Glycine, Sucrose, Tween® 80 and Glutamic Acid with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human, Mouse, Rat
observed molecular weight :
15-16 kDa, reducing conditions
theoretical molecular weight :
13 kDa (monomer)
gene symbol :
BMP2
details of functionality :
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Binnerts, M.E. et al . (2004) Biochem. Biophys. Res. Commun. 315(2) :272. The ED50 for this effect is 40-200 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P12643
applications :
Bioactivity
source :
CHO-derived Recombinant Human/Mouse/Rat BMP-2 Protein
extended description :
More economical E. coli option available
USD :
416 USD
product details :
More economical E. coli option available
alt names :
BDA2, BMP2, BMP-2, BMP-2A, BMP2ABone morphogenetic protein 2A, bone morphogenetic protein 2, SSFSC
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.