This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human BMP-7 Protein
catalog :
354-BP
quantity :
10 ug
price :
429 USD
citations: 73
Reference
Ali M, Kabir F, Thomson J, Ma Y, Qiu C, Delannoy M, et al. Comparative transcriptome analysis of hESC- and iPSC-derived lentoid bodies. Sci Rep. 2019;9:18552 pubmed publisher
Seo D, Jung S, Park J, Lee J, Ha J, Kim M, et al. The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway. EBioMedicine. 2019;49:55-71 pubmed publisher
Omi M, Kaartinen V, Mishina Y. Activin A receptor type 1-mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD-signaling pathway. J Biol Chem. 2019;294:17818-17836 pubmed publisher
Kamperman T, Koerselman M, Kelder C, Hendriks J, Crispim J, de Peuter X, et al. Spatiotemporal material functionalization via competitive supramolecular complexation of avidin and biotin analogs. Nat Commun. 2019;10:4347 pubmed publisher
Muller S, Ader I, Creff J, Leménager H, Achard P, Casteilla L, et al. Human adipose stromal-vascular fraction self-organizes to form vascularized adipose tissue in 3D cultures. Sci Rep. 2019;9:7250 pubmed publisher
Klusóczki Á, Veréb Z, Vámos A, Fischer Posovszky P, Wabitsch M, Bacso Z, et al. Differentiating SGBS adipocytes respond to PPARγ stimulation, irisin and BMP7 by functional browning and beige characteristics. Sci Rep. 2019;9:5823 pubmed publisher
Harms M, Li Q, Lee S, Zhang C, Kull B, Hallen S, et al. Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes. Cell Rep. 2019;27:213-225.e5 pubmed publisher
Ho W, Freem L, Zhao D, Painter K, Woolley T, Gaffney E, et al. Feather arrays are patterned by interacting signalling and cell density waves. PLoS Biol. 2019;17:e3000132 pubmed publisher
Kijewska M, Viski C, Turrell F, Fitzpatrick A, van Weverwijk A, Gao Q, et al. Using an in-vivo syngeneic spontaneous metastasis model identifies ID2 as a promoter of breast cancer colonisation in the brain. Breast Cancer Res. 2019;21:4 pubmed publisher
Weng C, Ding P, Liu Y, Hawse J, Subramaniam M, Wu C, et al. Mutant Kras-induced upregulation of CD24 enhances prostate cancer stemness and bone metastasis. Oncogene. 2019;38:2005-2019 pubmed publisher
Huang X, Zhong L, Post J, Karperien M. Co-treatment of TGF-?3 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments. Sci Rep. 2018;8:10251 pubmed publisher
Chen C, Bai G, Jin H, Lei K, Li K. Local injection of bone morphogenetic protein 7 promotes neuronal regeneration and motor function recovery after acute spinal cord injury. Neural Regen Res. 2018;13:1054-1060 pubmed publisher
Gadelorge M, Bourdens M, Espagnolle N, Bardiaux C, Murrell J, Savary L, et al. Clinical-scale expansion of adipose-derived stromal cells starting from stromal vascular fraction in a single-use bioreactor: proof of concept for autologous applications. J Tissue Eng Regen Med. 2018;12:129-141 pubmed publisher
Hino K, Horigome K, Nishio M, Komura S, Nagata S, Zhao C, et al. Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva. J Clin Invest. 2017;127:3339-3352 pubmed publisher
Sallon C, Callebaut I, Boulay I, Fontaine J, Logeart Avramoglou D, Henriquet C, et al. Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells. J Biol Chem. 2017;292:15352-15368 pubmed publisher
Guo X, Li F, Xu Z, Yin A, Yin H, Li C, et al. DOCK2 deficiency mitigates HFD-induced obesity by reducing adipose tissue inflammation and increasing energy expenditure. J Lipid Res. 2017;58:1777-1784 pubmed publisher
Wongwitwichot P, Kaewsrichan J. Osteogenic differentiation of mesenchymal stem cells is impaired by bone morphogenetic protein 7. Adv Med Sci. 2017;62:266-272 pubmed publisher
Bollum L, Huse K, Oksvold M, Bai B, Hilden V, Forfang L, et al. BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5. PLoS ONE. 2017;12:e0177188 pubmed publisher
Raja E, Komuro A, Tanabe R, Sakai S, Ino Y, Saito N, et al. Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells. Oncogene. 2017;36:4963-4974 pubmed publisher
Hammers D, Merscham Banda M, Hsiao J, ENGST S, Hartman J, Sweeney H. Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med. 2017;9:531-544 pubmed publisher
Shiraishi A, Muguruma K, Sasai Y. Generation of thalamic neurons from mouse embryonic stem cells. Development. 2017;144:1211-1220 pubmed publisher
Chattopadhyay T, Singh R, Gupta S, Surolia A. Bone morphogenetic protein-7 (BMP-7) augments insulin sensitivity in mice with type II diabetes mellitus by potentiating PI3K/AKT pathway. Biofactors. 2017;43:195-209 pubmed publisher
Yu Z, Mouillesseaux K, Kushner E, Bautch V. Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication. PLoS ONE. 2016;11:e0168334 pubmed publisher
Brunmeir R, Wu J, Peng X, Kim S, Julien S, Zhang Q, et al. Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis. PLoS Genet. 2016;12:e1006474 pubmed publisher
Picarda G, Chéneau C, Humbert J, Beriou G, Pilet P, Martin J, et al. Functional Langerinhigh-Expressing Langerhans-like Cells Can Arise from CD14highCD16- Human Blood Monocytes in Serum-Free Condition. J Immunol. 2016;196:3716-28 pubmed publisher
Kjartansdóttir K, Reda A, Panula S, Day K, Hultenby K, Söder O, et al. A Combination of Culture Conditions and Gene Expression Analysis Can Be Used to Investigate and Predict hES Cell Differentiation Potential towards Male Gonadal Cells. PLoS ONE. 2015;10:e0144029 pubmed publisher
Willems N, Bach F, Plomp S, Van Rijen M, Wolfswinkel J, Grinwis G, et al. Intradiscal application of rhBMP-7 does not induce regeneration in a canine model of spontaneous intervertebral disc degeneration. Arthritis Res Ther. 2015;17:137 pubmed publisher
Handorf A, Chamberlain C, Li W. Endogenously produced Indian Hedgehog regulates TGFβ-driven chondrogenesis of human bone marrow stromal/stem cells. Stem Cells Dev. 2015;24:995-1007 pubmed publisher
Moisan A, Lee Y, Zhang J, Hudak C, Meyer C, Prummer M, et al. White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015;17:57-67 pubmed publisher
Thiede B, Mann Z, Chang W, Ku Y, Son Y, Lovett M, et al. Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea. Nat Commun. 2014;5:3840 pubmed publisher
Mann Z, Thiede B, Chang W, Shin J, May Simera H, Lovett M, et al. A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear. Nat Commun. 2014;5:3839 pubmed publisher
Jin Q, Giannobile W. SDF-1 enhances wound healing of critical-sized calvarial defects beyond self-repair capacity. PLoS ONE. 2014;9:e97035 pubmed publisher
Ge D, Zhang Q, Zabaleta J, Zhang Q, Liu S, Reiser B, et al. Doublecortin may play a role in defining chondrocyte phenotype. Int J Mol Sci. 2014;15:6941-60 pubmed publisher
Miyagawa S, Ogino Y, Harada M, Ishii K, Sugimura Y, Ogino H, et al. Essential roles of epithelial bone morphogenetic protein signaling during prostatic development. Endocrinology. 2014;155:2534-44 pubmed publisher
Sharma A, Huard C, Vernochet C, Ziemek D, Knowlton K, Tyminski E, et al. Brown fat determination and development from muscle precursor cells by novel action of bone morphogenetic protein 6. PLoS ONE. 2014;9:e92608 pubmed publisher
Yamada S, Nakamura J, Asada M, Takase M, Matsusaka T, Iguchi T, et al. Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury. PLoS ONE. 2014;9:e89135 pubmed publisher
Goyal A, CHAVEZ S, Reijo Pera R. Generation of human induced pluripotent stem cells using epigenetic regulators reveals a germ cell-like identity in partially reprogrammed colonies. PLoS ONE. 2013;8:e82838 pubmed publisher
Xue R, Wan Y, Zhang S, Zhang Q, Ye H, Li Y. Role of bone morphogenetic protein 4 in the differentiation of brown fat-like adipocytes. Am J Physiol Endocrinol Metab. 2014;306:E363-72 pubmed publisher
Brady K, Dickinson S, Guillot P, Polak J, Blom A, Kafienah W, et al. Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis. Stem Cells Dev. 2014;23:541-54 pubmed publisher
Long J, Badal S, Wang Y, Chang B, Rodriguez A, Danesh F. MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney. J Biol Chem. 2013;288:36202-14 pubmed publisher
Lorda Diez C, Montero J, Choe S, Garcia Porrero J, Hurle J. Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro. J Bone Miner Res. 2014;29:735-48 pubmed publisher
Deschaseaux F, Gaillard J, Langonne A, Chauveau C, Naji A, Bouacida A, et al. Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue. FASEB J. 2013;27:2977-87 pubmed publisher
Glister C, Satchell L, Bathgate R, Wade J, Dai Y, Ivell R, et al. Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production. Proc Natl Acad Sci U S A. 2013;110:E1426-35 pubmed publisher
Okumura N, Kay E, Nakahara M, Hamuro J, Kinoshita S, Koizumi N. Inhibition of TGF-? signaling enables human corneal endothelial cell expansion in vitro for use in regenerative medicine. PLoS ONE. 2013;8:e58000 pubmed publisher
Narayanan K, Schumacher K, Tasnim F, Kandasamy K, Schumacher A, Ni M, et al. Human embryonic stem cells differentiate into functional renal proximal tubular-like cells. Kidney Int. 2013;83:593-603 pubmed publisher
Mae S, Shono A, Shiota F, Yasuno T, Kajiwara M, Gotoda Nishimura N, et al. Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells. Nat Commun. 2013;4:1367 pubmed publisher
Huse K, Bakkebø M, Walchli S, Oksvold M, Hilden V, Forfang L, et al. Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma. PLoS ONE. 2012;7:e46117 pubmed publisher
Wu Q, Sun C, Lin H, Babitt J. Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS ONE. 2012;7:e46307 pubmed publisher
Kim M, Yoon S, Lee S, Ha S, Kim H, Kim J, et al. Gremlin-1 induces BMP-independent tumor cell proliferation, migration, and invasion. PLoS ONE. 2012;7:e35100 pubmed publisher
Han L, Wen Z, Lynn R, Baudet M, Holt C, Sasaki Y, et al. Regulation of chemotropic guidance of nerve growth cones by microRNA. Mol Brain. 2011;4:40 pubmed publisher
Mottershead D, Ritter L, Gilchrist R. Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15. Mol Hum Reprod. 2012;18:121-8 pubmed publisher
Huse K, Bakkebø M, Oksvold M, Forfang L, Hilden V, Stokke T, et al. Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7. Eur J Immunol. 2011;41:3135-45 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Geens M, Sermon K, Van De Velde H, Tournaye H. Sertoli cell-conditioned medium induces germ cell differentiation in human embryonic stem cells. J Assist Reprod Genet. 2011;28:471-80 pubmed publisher
Hackett T, Warner S, Stefanowicz D, Shaheen F, Pechkovsky D, Murray L, et al. Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1. Am J Respir Crit Care Med. 2009;180:122-33 pubmed publisher
Little S, Mullins M. Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nat Cell Biol. 2009;11:637-43 pubmed publisher
Herrera B, Inman G. A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol. 2009;10:20 pubmed publisher
Tseng Y, Kokkotou E, Schulz T, Huang T, Winnay J, Taniguchi C, et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature. 2008;454:1000-4 pubmed publisher
Sengle G, Ono R, Lyons K, Bachinger H, Sakai L. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol. 2008;381:1025-39 pubmed publisher
Sengle G, Charbonneau N, Ono R, Sasaki T, Alvarez J, Keene D, et al. Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J Biol Chem. 2008;283:13874-88 pubmed publisher
Lin H, Shabbir A, Molnar M, Yang J, Marion S, Canty J, et al. Adenoviral expression of vascular endothelial growth factor splice variants differentially regulate bone marrow-derived mesenchymal stem cells. J Cell Physiol. 2008;216:458-68 pubmed publisher
Shiraki N, Yoshida T, Araki K, Umezawa A, Higuchi Y, Goto H, et al. Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm. Stem Cells. 2008;26:874-85 pubmed publisher
Zilberberg L, Ten Dijke P, Sakai L, Rifkin D. A rapid and sensitive bioassay to measure bone morphogenetic protein activity. BMC Cell Biol. 2007;8:41 pubmed
Fuller M, DeChant A, Rothstein B, Caprariello A, Wang R, Hall A, et al. Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions. Ann Neurol. 2007;62:288-300 pubmed
Wen Z, Han L, Bamburg J, Shim S, Ming G, Zheng J. BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin. J Cell Biol. 2007;178:107-19 pubmed publisher
Salero E, Hatten M. Differentiation of ES cells into cerebellar neurons. Proc Natl Acad Sci U S A. 2007;104:2997-3002 pubmed
Kiyono M, Shibuya M. Inhibitory Smad transcription factors protect arterial endothelial cells from apoptosis induced by BMP4. Oncogene. 2006;25:7131-7 pubmed
Maeshima A, Vaughn D, Choi Y, Nigam S. Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev Biol. 2006;295:473-85 pubmed
Holzschuh J, Wada N, Wada C, Schaffer A, Javidan Y, Tallafuss A, et al. Requirements for endoderm and BMP signaling in sensory neurogenesis in zebrafish. Development. 2005;132:3731-42 pubmed
Steinberg Z, Myers C, Heim V, Lathrop C, Rebustini I, Stewart J, et al. FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis. Development. 2005;132:1223-34 pubmed
Peterson R, Andhare R, Rousche K, Knudson W, Wang W, Grossfield J, et al. CD44 modulates Smad1 activation in the BMP-7 signaling pathway. J Cell Biol. 2004;166:1081-91 pubmed
Knosp W, Scott V, Bachinger H, Stadler H. HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis. Development. 2004;131:4581-92 pubmed
Jaskoll T, Witcher D, Toreno L, Bringas P, Moon A, Melnick M. FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis. Dev Biol. 2004;268:457-69 pubmed
product information
brand :
R&D Systems
master code :
354-BP
SKU :
354-BP-010
product name :
Recombinant Human BMP-7 Protein
description :
The Recombinant Human BMP-7 Protein from R&D Systems is derived from CHO. The Recombinant Human BMP-7 Protein has been validated for the following applications: Bioactivity.
target :
BMP-7
category :
Proteins and Enzymes
unit size :
10 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
18-20 kDa, reducing conditions
theoretical molecular weight :
15.7 kDa (monomer)
gene symbol :
BMP7
details of functionality :
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al . (1999) Exp. Cell Res. 250 :351. The ED50 for this effect is 0.1-0.6 µg/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
catalog number base :
354-BP
accessionNumbers :
P18075
applications :
Bioactivity
source :
Chinese Hamster Ovary cell line, CHO-derived human BMP-7 protein Ser293-His431
2020 USD :
429
2021 USD :
429 USD
alt names :
BMP7, BMP-7, bone morphogenetic protein 7, Eptotermin alfa, OP-1, OP-1OP1, Osteogenic protein 1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.