Recombinant Mouse Galectin-9 Protein, CF | R&D Systems 3535-GA-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Galectin-9 Protein, CF

catalog :

3535-GA-050

quantity :

50 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 12

Reference
Xiong H, Xue G, Zhang Y, Wu S, Zhao Q, Zhao R, et al. Effect of exogenous galectin-9, a natural TIM-3 ligand, on the severity of TNBS- and DSS-induced colitis in mice. Int Immunopharmacol. 2023;115:109645 pubmed publisher
Schatton T, Itoh Y, Martins C, Rasbach E, Singh P, Silva M, et al. Inhibition of Melanoma Cell-Intrinsic Tim-3 Stimulates MAPK-Dependent Tumorigenesis. Cancer Res. 2022;82:3774-3784 pubmed publisher
Smith L, Fawaz K, Treanor B. Galectin-9 regulates the threshold of B cell activation and autoimmunity. elife. 2021;10: pubmed publisher
Sudhakar J, Lu H, Chiang H, Suen C, Hwang M, Wu S, et al. Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas. Nat Commun. 2020;11:4286 pubmed publisher
Nakajima R, Miyagaki T, Kamijo H, Oka T, Shishido Takahashi N, Suga H, et al. Possible therapeutic applicability of galectin-9 in cutaneous T-cell lymphoma. J Dermatol Sci. 2019;96:134-142 pubmed publisher
Liang C, Li C, Weng I, Chen H, Lu H, Huang C, et al. Galectin-9 Is Critical for Mucosal Adaptive Immunity through the T Helper 17-IgA Axis. Am J Pathol. 2018;188:1225-1235 pubmed publisher
de Kivit S, Kostadinova A, Kerperien J, Morgan M, Muruzabal V, Hofman G, et al. Dietary, nondigestible oligosaccharides and Bifidobacterium breve M-16V suppress allergic inflammation in intestine via targeting dendritic cell maturation. J Leukoc Biol. 2017;102:105-115 pubmed publisher
Daley D, Mani V, Mohan N, Akkad N, Ochi A, Heindel D, et al. Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance. Nat Med. 2017;23:556-567 pubmed publisher
Steichen A, Simonson T, Salmon S, Metzger D, Mishra B, Sharma J. Alarmin function of galectin-9 in murine respiratory tularemia. PLoS ONE. 2015;10:e0123573 pubmed publisher
Steelman A, Li J. Astrocyte galectin-9 potentiates microglial TNF secretion. J Neuroinflammation. 2014;11:144 pubmed publisher
Ungerer C, Quade Lyssy P, Radeke H, Henschler R, Konigs C, Köhl U, et al. Galectin-9 is a suppressor of T and B cells and predicts the immune modulatory potential of mesenchymal stromal cell preparations. Stem Cells Dev. 2014;23:755-66 pubmed publisher
Leitner J, Rieger A, Pickl W, Zlabinger G, Grabmeier Pfistershammer K, Steinberger P. TIM-3 does not act as a receptor for galectin-9. PLoS Pathog. 2013;9:e1003253 pubmed publisher

image

image 1 :

Recombinant Mouse Galectin-9 Protein Bioactivity

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

3535-GA

SKU :

3535-GA-050

product name :

Recombinant Mouse Galectin-9 Protein, CF

Description :

The Recombinant Mouse Galectin-9 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Mouse Galectin-9 Protein, CF has been validated for the following applications: Bioactivity.

target :

Galectin-9

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in MOPS, NaCl, EDTA, DTT and Trehalose.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Mouse

observed molecular weight :

36 kDa, reducing conditions

theoretical molecular weight :

36.4 kDa

gene symbol :

Lgals9

details of functionality :

Measured by the ability of the immobilized protein to support the adhesion of D10.G4.1 mouse helper T cells. The ED50 for this effect is 0.6-3 µg/mL.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

NP_001152773

applications :

Bioactivity

source :

E. coli-derived Recombinant Mouse Galectin-9 Protein

USD :

423 USD

alt names :

ecalectin, gal-9, GAL9, galectin 9, galectin-9, Galectin9, HUAT, lectin, galactoside-binding, soluble, 9, LGALS9, LGALS9A, MGC117375, MGC125973, MGC125974, Tumor antigen HOM-HD-21, urate transporter/channel protein

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage