Recombinant Human MSP/MST1 Protein, CF | R&D Systems 352-MS-010/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human MSP/MST1 Protein, CF

catalog :

352-MS-010/CF

quantity :

10 ug (also 50 ug)

price :

365 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Khaibullina A, Adjei E, Afangbedji N, Ivanov A, Kumari N, Almeida L, et al. RON kinase inhibition reduces renal endothelial injury in sickle cell disease mice. Haematologica. 2018;103:787-798 pubmed publisher
Yin B, Liu Z, Wang Y, Wang X, Liu W, Yu P, et al. RON and c-Met facilitate metastasis through the ERK signaling pathway in prostate cancer cells. Oncol Rep. 2017;37:3209-3218 pubmed publisher
Vladimer G, Snijder B, Krall N, Bigenzahn J, Huber K, Lardeau C, et al. Global survey of the immunomodulatory potential of common drugs. Nat Chem Biol. 2017;13:681-690 pubmed publisher
Zhou D, Li C, Yang L. Variant RONÎ”160 of the RON receptor tyrosine kinase promotes the growth and invasion in vitro and in vivo in gastric cancer cell lines. Cancer Cell Int. 2015;15:9 pubmed publisher
Yang C, Kim J, Kim T, Lee P, Kim S, Lee H, et al. Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome. Nat Commun. 2015;6:6115 pubmed publisher
Bhatt A, Welm A, Farady C, Vasquez M, Wilson K, Craik C. Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway. Proc Natl Acad Sci U S A. 2007;104:5771-6 pubmed
Gunella G, Bardelli C, Amoruso A, Viano I, Balbo P, Brunelleschi S. Macrophage-stimulating protein differently affects human alveolar macrophages from smoker and non-smoker patients: evaluation of respiratory burst, cytokine release and NF-kappaB pathway. Br J Pharmacol. 2006;148:478-89 pubmed
Rampino T, Collesi C, Gregorini M, Maggio M, Soccio G, Guallini P, et al. Macrophage-stimulating protein is produced by tubular cells and activates mesangial cells. J Am Soc Nephrol. 2002;13:649-57 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

352-MS/CF

SKU :

352-MS-010/CF

product name :

Recombinant Human MSP/MST1 Protein, CF

Description :

The Recombinant Human MSP/MST1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human MSP/MST1 Protein, CF has been validated for the following applications: Bioactivity.

target :

MSP/MST1

category :

Proteins and Enzymes

unit size :

10 ug (also 50 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

81 kDa, 62 kDa and 30 kDa, reducing conditions

theoretical molecular weight :

78.5 kDa (MSP alpha/beta ); 53.3 kDa ( alpha chain), 25.2 kDa ( beta chain)

gene symbol :

MST1

details of functionality :

Measured by its ability to activate MSP R/Ron in MDA-MB-453 or T47D human breast cancer cells. 80 ng/mL of the recombinant human MSP significantly induces phosphorylation of MSP R/Ron measured by the Human Phospho-MSP R/Ron DuoSet® IC Kit (Catalog # DYC1947 ). Measured by its binding ability in a functional ELISA. When Recombinant Human MSPR/Ron Protein (Catalog #1947-MS) is represent at 100 ng/mL (100 µg/mL), The concentration of Recombinant Human MSP/MST1 that produces 50% optimal binding response is found to be 8-40 ng/mL.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

AAA59872

applications :

Bioactivity

source :

NS0-derived Recombinant Human MSP/MST1 Protein

USD :

365 USD

alt names :

D3F15S2, EC 3.4.21, hepatocyte growth factor-like protein homolog, HGFL, HGFLhepatocyte growth factor-like protein, macrophage stimulating 1 (hepatocyte growth factor-like), Macrophage stimulatory protein, Macrophage-stimulating protein, MSPDNF15S2, MST1, NF15S2, SF2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage