Recombinant Mouse Norrin Protein | R&D Systems 3497-NR-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse Norrin Protein

catalog :

3497-NR-025

quantity :

25 ug

price :

514 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Hao J, Liu C, Gu Z, Yang X, Lan X, Guo X. Dysregulation of Wnt/β-catenin signaling contributes to intestinal inflammation through regulation of group 3 innate lymphoid cells. Nat Commun. 2024;15:2820 pubmed publisher
Strakova K, Matricon P, Yokota C, Arthofer E, Bernatik O, Rodriguez D, et al. The tyrosine Y2502.39 in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled. Cell Signal. 2017;38:85-96 pubmed publisher
Ma M, Zhang Z, Du E, Zheng W, Gu Q, Xu X, et al. Wnt signaling in form deprivation myopia of the mice retina. PLoS ONE. 2014;9:e91086 pubmed publisher

product information

master code :

3497-NR

SKU :

3497-NR-025

product name :

Recombinant Mouse Norrin Protein

unit size :

25 ug

description :

The Recombinant Mouse Norrin Protein from R&D Systems is derived from E. coli. The Recombinant Mouse Norrin Protein has been validated for the following applications: Bioactivity.

target :

Norrin

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in HCl with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Mouse

theoretical molecular weight :

12.3 kDa (monomer)

details of functionality :

Measured by its ability to activate Wnt induced TCF reporter activity in HEK293 human embryonic kidney cells expressing human Frizzled-4 and human LRP-5. The ED50 for this effect is 40-200 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P48744

applications :

Bioactivity

source long :

E. coli -derived mouse Norrin protein Lys25-Ser131, with an N-terminal Met

source short :

E. coli

USD :

514 USD

alt names :

EVR2, exudative vitreoretinopathy 2 (X-linked), FEVR, ND, NDP, Norrie disease (pseudoglioma), Norrie disease protein, norrin, X-linked exudative vitreoretinopathy 2 protein

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage