Recombinant Human ErbB3/Her3 Fc Chimera Protein, CF | R&D Systems 348-RB-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human ErbB3/Her3 Fc Chimera Protein, CF

catalog :

348-RB-050

quantity :

50 ug

price :

434 USD

more info or order :

R&D Systems product webpage

citations: 12

Reference
Gutsch D, Jenke R, Buch T, Aigner A. Inhibition of HER Receptors Reveals Distinct Mechanisms of Compensatory Upregulation of Other HER Family Members: Basis for Acquired Resistance and for Combination Therapy. Cells. 2021;10: pubmed publisher
El Sayed A, Bernhard W, Barreto K, Gonzalez C, Hill W, Pastushok L, et al. Evaluation of antibody fragment properties for near-infrared fluorescence imaging of HER3-positive cancer xenografts. Theranostics. 2018;8:4856-4869 pubmed publisher
Memon A, Gilliver S, Borre M, Sundquist J, Sundquist K, Nexo E, et al. Soluble HER3 predicts survival in bladder cancer patients. Oncol Lett. 2018;15:1783-1788 pubmed publisher
Yun M, Kim D, Lee J, Kim H, Kim H, Pyo A, et al. A High-Affinity Repebody for Molecular Imaging of EGFR-Expressing Malignant Tumors. Theranostics. 2017;7:2620-2633 pubmed publisher
Shinozaki N, Hashimoto R, Fukui K, Uchiyama S. Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities. Sci Rep. 2017;7:5794 pubmed publisher
Le Clorennec C, BAZIN H, Dubreuil O, Larbouret C, Ogier C, Lazrek Y, et al. Neuregulin 1 Allosterically Enhances the Antitumor Effects of the Noncompeting Anti-HER3 Antibody 9F7-F11 by Increasing Its Binding to HER3. Mol Cancer Ther. 2017;16:1312-1323 pubmed publisher
Miyamoto Y, Torii T, Tanoue A, Kawahara K, Arai M, Tsumura H, et al. Neuregulin-1 type III knockout mice exhibit delayed migration of Schwann cell precursors. Biochem Biophys Res Commun. 2017;486:506-513 pubmed publisher
Leung I, Jarvik N, Sidhu S. A Highly Diverse and Functional Naïve Ubiquitin Variant Library for Generation of Intracellular Affinity Reagents. J Mol Biol. 2017;429:115-127 pubmed publisher
Leung K, Batey S, Rowlands R, Isaac S, Jones P, Drewett V, et al. A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis. Mol Ther. 2015;23:1722-1733 pubmed publisher
Xu L, Kohli N, Rennard R, Jiao Y, Razlog M, Zhang K, et al. Rapid optimization and prototyping for therapeutic antibody-like molecules. MAbs. 2013;5:237-54 pubmed publisher
Feldwisch J, Tolmachev V, Lendel C, Herne N, Sjöberg A, Larsson B, et al. Design of an optimized scaffold for affibody molecules. J Mol Biol. 2010;398:232-47 pubmed publisher
Hamra F, Chapman K, Nguyen D, Garbers D. Identification of neuregulin as a factor required for formation of aligned spermatogonia. J Biol Chem. 2007;282:721-30 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

348-RB

SKU :

348-RB-050

product name :

Recombinant Human ErbB3/Her3 Fc Chimera Protein, CF

Description :

The Recombinant Human ErbB3/Her3 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ErbB3/Her3 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

ErbB3/Her3

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

130-140 kDa, reducing conditions

theoretical molecular weight :

96 kDa (monomer)

gene symbol :

ERBB3

details of functionality :

Measured by its ability to inhibit the biological activity of Neuregulin-1-beta 1 on MCF-7 human breast cancer cells. Karey, K.P. et al . (1988) Cancer Research 48 :4083. The ED50 for this effect is 1.5-6.0 µg/mL in the presence of 10 ng/mL Recombinant Human NRG1-beta 1/HRG1-beta 1 Extracellular Domain (Catalog # 377-HB ).

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P21860

applications :

Bioactivity

source :

NS0-derived Recombinant Human ErbB3/Her3 Fc Chimera Protein

USD :

434 USD

alt names :

c-erbB3, EC 2.7.10, EC 2.7.10.1, ErbB-3, erbB3-S, HER3, HER3c-erbB-3, LCCS2, lethal congenital contracture syndrome 2, MDA-BF-1, MGC88033, p180-ErbB3, p45-sErbB3, p85-sErbB3, Proto-oncogene-like protein c-ErbB-3, receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage