Recombinant Human TRAILR1/TNFRSF10A Fc Chimera Protein | R&D Systems 347-DR product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human TRAILR1/TNFRSF10A Fc Chimera Protein

catalog :

347-DR

quantity :

100 ug

price :

359 USD

citations: 5

Reference
Kim E, Kim A. Combination effect of equol and TRAIL against human cervical cancer cells. Anticancer Res. 2013;33:903-12 pubmed
Peppa D, Gill U, Reynolds G, Easom N, Pallett L, Schurich A, et al. Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion. J Exp Med. 2013;210:99-114 pubmed publisher
Bellucci R, Nguyen H, Martin A, Heinrichs S, Schinzel A, Hahn W, et al. Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells. J Clin Invest. 2012;122:2369-83 pubmed publisher
Gasparian M, Chernyak B, Dolgikh D, Yagolovich A, Popova E, Sycheva A, et al. Generation of new TRAIL mutants DR5-A and DR5-B with improved selectivity to death receptor 5. Apoptosis. 2009;14:778-87 pubmed publisher
He Q, Lee D, Rong R, Yu M, Luo X, Klein M, et al. Endoplasmic reticulum calcium pool depletion-induced apoptosis is coupled with activation of the death receptor 5 pathway. Oncogene. 2002;21:2623-33 pubmed

product information

brand :

R&D Systems

master code :

347-DR

SKU :

347-DR-100

product name :

Recombinant Human TRAILR1/TNFRSF10A Fc Chimera Protein

description :

The Recombinant Human TRAILR1/TNFRSF10A Fc Chimera Protein from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human TRAILR1/TNFRSF10A Fc Chimera Protein has been validated for the following applications: Bioactivity.

target :

TRAILR1/TNFRSF10A

category :

Proteins and Enzymes

unit size :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

46 kDa, reducing conditions

theoretical molecular weight :

43 kDa (monomer)

gene symbol :

TNFRSF10A

details of functionality :

Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L-929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 1-3 ng/mL in the presence of 6 ng/mL of Recombinant Human TRAIL/TNFSF10 (Catalog # 375-TEC).

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

catalog number base :

347-DR

accessionNumbers :

AAC51226

applications :

Bioactivity

source :

Spodoptera frugiperda , Sf 21 (baculovirus)-derived human TRAIL R1/TNFRSF10A protein Human TRAIL R1 (Ala109 - Asn239) (Thr110 - Asn239) Accession # AAC51226 IEGRMD Human IgG1 (Pro100 - Lys330) 6-His tag N-terminus C-terminus

extended description :

A New rh TRAIL R1 is Now Available! ~2 fold better activity; CHO expressed; No his tag!

2020 USD :

359

2021 USD :

359 USD

product details :

A New rh TRAIL R1 is Now Available! ~2 fold better activity; CHO expressed; No his tag!

alt names :

APO2, CD261, CD261 antigen, cytotoxic TRAIL receptor, Death receptor 4, DR4, DR4 TRAIL receptor 1, TNF-related apoptosis inducing ligand receptor 1, TNF-related apoptosis-inducing ligand receptor 1, TNFRSF10A, TRAIL R1, TRAIL-R1, TRAILR-1, TRAILR1MGC9365, tumor necrosis factor receptor superfamily member 10A, tumor necrosis factor receptor superfamily, member 10a

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.