Recombinant Human APP/Protease Nexin II Protein, CF | R&D Systems 3466-PI-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human APP/Protease Nexin II Protein, CF

catalog :

3466-PI-010

quantity :

10 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 2

Reference
Thomas R, Liddell J, Kidd E. Anti-amyloid precursor protein immunoglobulins inhibit amyloid-? production by steric hindrance. FEBS J. 2011;278:167-78 pubmed publisher
Ahmed R, Holler C, Webb R, Li F, Beckett T, Murphy M. BACE1 and BACE2 enzymatic activities in Alzheimer's disease. J Neurochem. 2010;112:1045-53 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

3466-PI

SKU :

3466-PI-010

product name :

Recombinant Human APP/Protease Nexin II Protein, CF

Description :

The Recombinant Human APP/Protease Nexin II Protein, CF from R&D Systems is derived from NS0. The Recombinant Human APP/Protease Nexin II Protein, CF has been validated for the following applications: Inhibition Activity.

target :

APP

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

120 kDa, reducing conditions

theoretical molecular weight :

77 kDa

gene symbol :

APP

details of functionality :

Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 (Catalog # ES002 ). The IC50 value is 1.2 nM, as measured with under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P05067

applications :

Inhibition Activity

source :

NS0-derived Recombinant Human APP/Protease Nexin II Protein

USD :

423 USD

alt names :

Amyloid beta, amyloid beta (A4) precursor protein-binding, family B, member 2, amyloid beta A4 precursor protein-binding family B member 2, Amyloid beta precursor protein, APP, beta Amyloid, Protease Nexin II

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage