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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human FGF-10 Protein
catalog :
345-FG-025
quantity :
25 ug (also 250 ug)
price :
302 USD
more info or order :
citations: 84
Reference
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Jiang T, Hu W, Zhang S, Ren C, Lin S, Zhou Z, et al. Fibroblast growth factor 10 attenuates chronic obstructive pulmonary disease by protecting against glycocalyx impairment and endothelial apoptosis. Respir Res. 2022;23:269 pubmed publisher
Jaboreck M, L xfc hmann J, Mielenz M, Stanke F, G xf6 hring G, Martin U, et al. Generation of two TMEM16A knockout iPSC clones each from a healthy human iPSC line, from a Cystic Fibrosis patient specific line with p.Phe508del mutation and from the gene corrected iPSC line. Stem Cell Res. 2022;64:102918 pubmed publisher
Lungová V, Wendt K, Thibeault S. Exposure to e-cigarette vapor extract induces vocal fold epithelial injury and triggers intense mucosal remodeling. Dis Model Mech. 2022;15: pubmed publisher
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Heynen G, Lisek K, Vogel R, Wulf Goldenberg A, Alcaniz J, Montaudon E, et al. Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors. Breast Cancer Res. 2022;24:23 pubmed publisher
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Eicher A, Kechele D, Sundaram N, Berns H, Poling H, Haines L, et al. Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells. Cell Stem Cell. 2022;29:36-51.e6 pubmed publisher
Johnson Chacko L, Lahlou H, Steinacher C, Assou S, Messat Y, Dudas J, et al. Transcriptome-Wide Analysis Reveals a Role for Extracellular Matrix and Integrin Receptor Genes in Otic Neurosensory Differentiation from Human iPSCs. Int J Mol Sci. 2021;22: pubmed publisher
Gkatzis K, Panza P, Peruzzo S, Stainier D. Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures. elife. 2021;10: pubmed publisher
Aghazadeh Y, Poon F, Sarangi F, Wong F, Khan S, Sun X, et al. Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models. Cell Stem Cell. 2021;28:1936-1949.e8 pubmed publisher
Lee M, Lee S, Jung C, Son Y, Ryu J, Jung K, et al. Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells. Nat Commun. 2021;12:4492 pubmed publisher
Rodrigues Toste de Carvalho A, Liu H, Chen Y, Porotto M, Moscona A, Snoeck H. The in vitro multilineage differentiation and maturation of lung and airway cells from human pluripotent stem cell-derived lung progenitors in 3D. Nat Protoc. 2021;16:1802-1829 pubmed publisher
Tomita H, Tanaka K, Hirata A, Okada H, Imai H, Shirakami Y, et al. Inhibition of FGF10-ERK signal activation suppresses intraductal papillary neoplasm of the bile duct and its associated carcinomas. Cell Rep. 2021;34:108772 pubmed publisher
Hawkins F, Suzuki S, Beermann M, Barillà C, Wang R, Villacorta Martin C, et al. Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 2021;28:79-95.e8 pubmed publisher
Hoffman M, Kemp S, Salas Escabillas D, Zhang Y, Steele N, The S, et al. The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice. Cell Mol Gastroenterol Hepatol. 2021;11:349-369 pubmed publisher
Cui L, Zheng J, Zhao Q, Chen J, Liu H, Peng G, et al. Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss. JCI Insight. 2020;5: pubmed publisher
Huang J, Hume A, Abo K, Werder R, Villacorta Martin C, Alysandratos K, et al. SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. Cell Stem Cell. 2020;27:962-973.e7 pubmed publisher
Duan F, Guo L, Yang L, Han Y, Thakur A, Nilsson Payant B, et al. Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2. Res Sq. 2020;: pubmed publisher
Huang J, Hume A, Abo K, Werder R, Villacorta Martin C, Alysandratos K, et al. SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. bioRxiv. 2020;: pubmed publisher
Chanthra N, Abe T, Miyamoto M, Sekiguchi K, Kwon C, Hanazono Y, et al. A Novel Fluorescent Reporter System Identifies Laminin-511/521 as Potent Regulators of Cardiomyocyte Maturation. Sci Rep. 2020;10:4249 pubmed publisher
Liang W, Han P, Kim E, Mak J, Zhang R, Torrente A, et al. Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells. Stem Cells. 2020;38:352-368 pubmed publisher
Matsumoto R, Suga H, Aoi T, Bando H, Fukuoka H, Iguchi G, et al. Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells. J Clin Invest. 2019;: pubmed publisher
Sahabian A, Sgodda M, Naujok O, Dettmer R, Dahlmann J, Manstein F, et al. Chemically-Defined, Xeno-Free, Scalable Production of hPSC-Derived Definitive Endoderm Aggregates with Multi-Lineage Differentiation Potential. Cells. 2019;8: pubmed publisher
Yung T, Poon F, Liang M, Coquenlorge S, McGaugh E, Hui C, et al. Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals. Nat Commun. 2019;10:4647 pubmed publisher
Lungová V, Chen X, Wang Z, Kendziorski C, Thibeault S. Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure. Nat Commun. 2019;10:4161 pubmed publisher
Suzuki K, Koyanagi Aoi M, Uehara K, Hinata N, Fujisawa M, Aoi T. Directed differentiation of human induced pluripotent stem cells into mature stratified bladder urothelium. Sci Rep. 2019;9:10506 pubmed publisher
Genga R, Kernfeld E, Parsi K, Parsons T, Ziller M, Maehr R. Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development. Cell Rep. 2019;27:708-718.e10 pubmed publisher
Toba Y, Kiso A, Nakamae S, Sakurai F, Takayama K, Mizuguchi H. FGF signal is not required for hepatoblast differentiation of human iPS cells. Sci Rep. 2019;9:3713 pubmed publisher
Noguchi H, Miyagi Shiohira C, Nakashima Y, Kinjo T, Kobayashi N, Saitoh I, et al. Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors. Mol Ther Methods Clin Dev. 2019;13:243-252 pubmed publisher
Kumtornrut C, Yamauchi T, Koike S, Aiba S, Yamasaki K. Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts. J Dermatol Sci. 2019;93:150-158 pubmed publisher
Muraoka N, Nara K, Tamura F, Kojima H, Yamakawa H, Sadahiro T, et al. Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming. Nat Commun. 2019;10:674 pubmed publisher
Miller A, Dye B, Ferrer Torres D, Hill D, Overeem A, Shea L, et al. Generation of lung organoids from human pluripotent stem cells in vitro. Nat Protoc. 2019;14:518-540 pubmed publisher
Scavuzzo M, Chmielowiec J, Yang D, Wamble K, Chaboub L, Duraine L, et al. Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA. Cell Rep. 2018;25:3811-3827.e7 pubmed publisher
Chagraoui H, Kristiansen M, Ruiz J, Serra Barros A, Richter J, Hall Ponsele E, et al. SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells. Nat Commun. 2018;9:5375 pubmed publisher
Broda T, McCracken K, Wells J. Generation of human antral and fundic gastric organoids from pluripotent stem cells. Nat Protoc. 2019;14:28-50 pubmed publisher
Zhang Y, Yang Y, Jiang M, Huang S, Zhang W, Al Alam D, et al. 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling. Cell Stem Cell. 2018;23:516-529.e5 pubmed publisher
Ng Blichfeldt J, Schrik A, Kortekaas R, Noordhoek J, Heijink I, Hiemstra P, et al. Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation. EBioMedicine. 2018;36:461-474 pubmed publisher
Cruz Acuña R, Quirós M, Huang S, Siuda D, Spence J, Nusrat A, et al. PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery. Nat Protoc. 2018;13:2102-2119 pubmed publisher
Zhang S, Zhao C, Liu S, Wang Y, Zhao Y, Guan W, et al. Characteristics and multi‑lineage differentiation of bone marrow mesenchymal stem cells derived from the Tibetan mastiff. Mol Med Rep. 2018;18:2097-2109 pubmed publisher
Lahlou H, Lopez Juarez A, Fontbonne A, Nivet E, Zine A. Modeling human early otic sensory cell development with induced pluripotent stem cells. PLoS ONE. 2018;13:e0198954 pubmed publisher
Guo X, Xu Y, Wang Z, Wu Y, Chen J, Wang G, et al. A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis. Cell Stem Cell. 2018;22:893-908.e6 pubmed publisher
Ostrin E, Little D, Gerner Mauro K, Sumner E, Ríos Corzo R, Ambrosio E, et al. β-Catenin maintains lung epithelial progenitors after lung specification. Development. 2018;145: pubmed publisher
Memon B, Karam M, Al Khawaga S, Abdelalim E. Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1. Stem Cell Res Ther. 2018;9:15 pubmed publisher
Dorrello N, Guenthart B, O Neill J, Kim J, Cunningham K, Chen Y, et al. Functional vascularized lung grafts for lung bioengineering. Sci Adv. 2017;3:e1700521 pubmed publisher
Cogger K, Sinha A, Sarangi F, McGaugh E, Saunders D, Dorrell C, et al. Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors. Nat Commun. 2017;8:331 pubmed publisher
Jimenez Caliani A, Pillich R, Yang W, Diaferia G, Meda P, Crisa L, et al. αE-Catenin Is a Positive Regulator of Pancreatic Islet Cell Lineage Differentiation. Cell Rep. 2017;20:1295-1306 pubmed publisher
Ball C, Oppel F, Ehrenberg K, Dubash T, Dieter S, Hoffmann C, et al. Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenografts. EMBO Mol Med. 2017;9:918-932 pubmed publisher
El Agha E, Kheirollahi V, Moiseenko A, Seeger W, Bellusci S. Ex vivo analysis of the contribution of FGF10+ cells to airway smooth muscle cell formation during early lung development. Dev Dyn. 2017;246:531-538 pubmed publisher
McCauley K, Hawkins F, Serra M, Thomas D, JACOB A, Kotton D. Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling. Cell Stem Cell. 2017;20:844-857.e6 pubmed publisher
Zhang Z, Newton K, Kummerfeld S, Webster J, Kirkpatrick D, Phu L, et al. Transcription factor Etv5 is essential for the maintenance of alveolar type II cells. Proc Natl Acad Sci U S A. 2017;114:3903-3908 pubmed publisher
Weeden C, Chen Y, Ma S, Hu Y, Ramm G, Sutherland K, et al. Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway. PLoS Biol. 2017;15:e2000731 pubmed publisher
Tao C, Zhang X. Retinal Proteoglycans Act as Cellular Receptors for Basement Membrane Assembly to Control Astrocyte Migration and Angiogenesis. Cell Rep. 2016;17:1832-1844 pubmed publisher
Liu J, Akanuma N, Liu C, Naji A, Halff G, Washburn W, et al. TGF-?1 promotes acinar to ductal metaplasia of human pancreatic acinar cells. Sci Rep. 2016;6:30904 pubmed publisher
Gozali M, Yi F, Zhang J, Liu J, Wu H, Xu Y, et al. Photodynamic therapy inhibit Fibroblast Growth Factor-10 induced keratinocyte differentiation and proliferation through ROS in Fibroblast Growth Factor Receptor-2b pathway. Sci Rep. 2016;6:27402 pubmed publisher
El Khatib M, Ohmine S, Jacobus E, Tonne J, Morsy S, Holditch S, et al. Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration. Stem Cells Transl Med. 2016;5:694-702 pubmed publisher
Comps Agrar L, Dunshee D, Eaton D, Sonoda J. Unliganded fibroblast growth factor receptor 1 forms density-independent dimers. J Biol Chem. 2015;290:24166-77 pubmed publisher
Calderon Gierszal E, Prins G. Directed Differentiation of Human Embryonic Stem Cells into Prostate Organoids In Vitro and its Perturbation by Low-Dose Bisphenol A Exposure. PLoS ONE. 2015;10:e0133238 pubmed publisher
Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, et al. The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma. BMC Cancer. 2015;15:82 pubmed publisher
Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D Souza S, et al. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Nat Protoc. 2015;10:413-25 pubmed publisher
Wong A, Chin S, Xia S, Garner J, Bear C, Rossant J. Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells. Nat Protoc. 2015;10:363-81 pubmed publisher
Maass K, Shekhar A, Lu J, Kang G, See F, Kim E, et al. Isolation and characterization of embryonic stem cell-derived cardiac Purkinje cells. Stem Cells. 2015;33:1102-12 pubmed publisher
Dalle Nogare D, Somers K, Rao S, Matsuda M, Reichman Fried M, Raz E, et al. Leading and trailing cells cooperate in collective migration of the zebrafish posterior lateral line primordium. Development. 2014;141:3188-96 pubmed publisher
Pethe P, Nagvenkar P, Bhartiya D. Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro. BMC Cell Biol. 2014;15:18 pubmed publisher
Kanehira M, Kikuchi T, Santoso A, Tode N, Hirano T, Ohkouchi S, et al. Human marrow stromal cells downsize the stem cell fraction of lung cancers by fibroblast growth factor 10. Mol Cell Biol. 2014;34:2848-56 pubmed publisher
Ohnuma K, Fujiki A, Yanagihara K, Tachikawa S, Hayashi Y, Ito Y, et al. Enzyme-free passage of human pluripotent stem cells by controlling divalent cations. Sci Rep. 2014;4:4646 pubmed publisher
Takeuchi H, Nakatsuji N, Suemori H. Endodermal differentiation of human pluripotent stem cells to insulin-producing cells in 3D culture. Sci Rep. 2014;4:4488 pubmed publisher
Hannan N, Fordham R, Syed Y, Moignard V, Berry A, Bautista R, et al. Generation of multipotent foregut stem cells from human pluripotent stem cells. Stem Cell Reports. 2013;1:293-306 pubmed publisher
Huang S, Islam M, O NEILL J, Hu Z, Yang Y, Chen Y, et al. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol. 2014;32:84-91 pubmed publisher
Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, et al. Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. elife. 2013;2:e00940 pubmed publisher
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Prabakar K, Dominguez Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, et al. Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells. Cell Transplant. 2012;21:1321-39 pubmed publisher
Patel N, Sharpe P, Miletich I. Coordination of epithelial branching and salivary gland lumen formation by Wnt and FGF signals. Dev Biol. 2011;358:156-67 pubmed publisher
Tomlinson D, Knowles M. Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer. Am J Pathol. 2010;177:2379-86 pubmed publisher
Borowiak M, Maehr R, Chen S, Chen A, Tang W, Fox J, et al. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell. 2009;4:348-58 pubmed publisher
Yamamoto S, Fukumoto E, Yoshizaki K, Iwamoto T, Yamada A, Tanaka K, et al. Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J Biol Chem. 2008;283:23139-49 pubmed publisher
Patel V, Likar K, Zisman Rozen S, Cowherd S, Lassiter K, Sher I, et al. Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation. J Biol Chem. 2008;283:9308-17 pubmed publisher
Cho Y, Lim J, Yoo D, Kim J, Chung S, Park S, et al. Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells. Biochem Biophys Res Commun. 2008;366:129-34 pubmed
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Mogi K, Goto M, Ohno E, Azumi Y, Takeuchi S, Toyoizumi R. Xenopus neurula left-right asymmetry is respeficied by microinjecting TGF-beta5 protein. Int J Dev Biol. 2003;47:15-29 pubmed
image
image 1 :
R&D Systems 345-FG-025 image 1
Recombinant Human FGF-10 Protein Bioactivity
product information
brand :
R&D Systems
master code :
345-FG
SKU :
345-FG-025
product name :
Recombinant Human FGF-10 Protein
description :
The Recombinant Human FGF-10 Protein from R&D Systems is derived from E. coli. The Recombinant Human FGF-10 Protein has been validated for the following applications: Bioactivity.
target :
FGF-10
category :
Proteins and Enzymes
unit sizes :
25 ug (also 250 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in MOPS, Na2SO4, EDTA and DTT with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
19-22 kDa, reducing conditions
theoretical molecular weight :
19.5 kDa
gene symbol :
FGF10
details of functionality :
Measured in a cell proliferation assay using 4MBr-5 rhesus monkey epithelial cells. Rubin, J.S. et al . (1989) Proc. Natl. Acad. Sci. USA 86 :802. The ED50 for this effect is 20-100 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
O15520
applications :
Bioactivity
source :
E. coli-derived Recombinant Human FGF-10 Protein
extended description :
Earn double rewards for reviews
USD :
302 USD
product details :
Earn double rewards for reviews
alt names :
FGF10, FGF-10, fibroblast growth factor 10, Keratinocyte growth factor 2, KGF2, KGF-2, produced by fibroblasts of urinary bladder lamina propria
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.