Recombinant Human EGFR Fc Chimera Protein, CF | R&D Systems 344-ER product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human EGFR Fc Chimera Protein, CF

catalog :

344-ER

quantity :

50 ug

price :

339 USD

citations: 12

Reference
Kadonosono T, Yimchuen W, Ota Y, See K, Furuta T, Shiozawa T, et al. Design Strategy to Create Antibody Mimetics Harbouring Immobilised Complementarity Determining Region Peptides for Practical Use. Sci Rep. 2020;10:891 pubmed publisher
Ahn S, Li J, Sun C, Gao K, Hirabayashi K, Li H, et al. Cancer Immunotherapy with T Cells Carrying Bispecific Receptors That Mimic Antibodies. Cancer Immunol Res. 2019;7:773-783 pubmed publisher
Pankratova S, Klingelhofer J, Dmytriyeva O, Owczarek S, Renziehausen A, Syed N, et al. The S100A4 Protein Signals through the ErbB4 Receptor to Promote Neuronal Survival. Theranostics. 2018;8:3977-3990 pubmed publisher
Kooijmans S, Gitz Francois J, Schiffelers R, Vader P. Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells: a plug-and-play approach. Nanoscale. 2018;10:2413-2426 pubmed publisher
Yun M, Kim D, Lee J, Kim H, Kim H, Pyo A, et al. A High-Affinity Repebody for Molecular Imaging of EGFR-Expressing Malignant Tumors. Theranostics. 2017;7:2620-2633 pubmed publisher
Wycisk V, Achazi K, Hirsch O, Kuehne C, Dernedde J, Haag R, et al. Heterobifunctional Dyes: Highly Fluorescent Linkers Based on Cyanine Dyes. ChemistryOpen. 2017;6:437-446 pubmed publisher
Stegmann C, Hochdorfer D, Lieber D, Subramanian N, Stöhr D, Laib Sampaio K, et al. A derivative of platelet-derived growth factor receptor alpha binds to the trimer of human cytomegalovirus and inhibits entry into fibroblasts and endothelial cells. PLoS Pathog. 2017;13:e1006273 pubmed publisher
Han X, Bryson P, Zhao Y, Cinay G, Li S, Guo Y, et al. Masked Chimeric Antigen Receptor for Tumor-Specific Activation. Mol Ther. 2017;25:274-284 pubmed publisher
Leung I, Jarvik N, Sidhu S. A Highly Diverse and Functional Naïve Ubiquitin Variant Library for Generation of Intracellular Affinity Reagents. J Mol Biol. 2017;429:115-127 pubmed publisher
Moores S, Chiu M, Bushey B, Chevalier K, Luistro L, Dorn K, et al. A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor-Resistant Lung Tumors. Cancer Res. 2016;76:3942-53 pubmed publisher
Leung K, Batey S, Rowlands R, Isaac S, Jones P, Drewett V, et al. A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis. Mol Ther. 2015;23:1722-1733 pubmed publisher
Feldwisch J, Tolmachev V, Lendel C, Herne N, Sjöberg A, Larsson B, et al. Design of an optimized scaffold for affibody molecules. J Mol Biol. 2010;398:232-47 pubmed publisher

product information

brand :

R&D Systems

master code :

344-ER

SKU :

344-ER-050

product name :

Recombinant Human EGFR Fc Chimera Protein, CF

description :

The Recombinant Human EGFR Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human EGFR Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

EGFR

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

125-145 kDa, reducing conditions

theoretical molecular weight :

95.1 kDa (monomer)

gene symbol :

EGFR

details of functionality :

Measured by its ability to bind recombinant human EGF in a functional ELISA with an estimated Kd 8 nM.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

344-ER

accessionNumbers :

CAA25240

applications :

Binding Activity

source :

Mouse myeloma cell line, NS0-derived human EGFR protein Human EGFR (Met1-Ser645) Accession # CAA25240 IEGRMD Human IgG1-Fc (Pro100-Lys330) N-terminus C-terminus

2020 USD :

339

2021 USD :

339 USD

alt names :

avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EC 2.7.10, EC 2.7.10.1, EGF R, epidermal growth factor receptor, epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b)oncogene homolog), ErbB, ErbB1, ERBB1PIG61, HER1, HER-1, mENA, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.