product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human EGFR Fc Chimera Protein, CF
catalog :
344-ER-050
quantity :
50 ug
price :
428 USD
more info or order :
R&D Systems product webpage
citations: 14
Reference
Dengl S, Mayer K, Bormann F, Duerr H, Hoffmann E, Nussbaum B, et al. Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices. Nat Commun. 2020;11:4974 pubmed publisher
Kondo T, Iwatani Y, Matsuoka K, Fujino T, Umemoto S, Yokomaku Y, et al. Antibody-like proteins that capture and neutralize SARS-CoV-2. Sci Adv. 2020;6: pubmed publisher
Kadonosono T, Yimchuen W, Ota Y, See K, Furuta T, Shiozawa T, et al. Design Strategy to Create Antibody Mimetics Harbouring Immobilised Complementarity Determining Region Peptides for Practical Use. Sci Rep. 2020;10:891 pubmed publisher
Ahn S, Li J, Sun C, Gao K, Hirabayashi K, Li H, et al. Cancer Immunotherapy with T Cells Carrying Bispecific Receptors That Mimic Antibodies. Cancer Immunol Res. 2019;7:773-783 pubmed publisher
Pankratova S, Klingelhofer J, Dmytriyeva O, Owczarek S, Renziehausen A, Syed N, et al. The S100A4 Protein Signals through the ErbB4 Receptor to Promote Neuronal Survival. Theranostics. 2018;8:3977-3990 pubmed publisher
Kooijmans S, Gitz Francois J, Schiffelers R, Vader P. Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells: a plug-and-play approach. Nanoscale. 2018;10:2413-2426 pubmed publisher
Yun M, Kim D, Lee J, Kim H, Kim H, Pyo A, et al. A High-Affinity Repebody for Molecular Imaging of EGFR-Expressing Malignant Tumors. Theranostics. 2017;7:2620-2633 pubmed publisher
Wycisk V, Achazi K, Hirsch O, Kuehne C, Dernedde J, Haag R, et al. Heterobifunctional Dyes: Highly Fluorescent Linkers Based on Cyanine Dyes. ChemistryOpen. 2017;6:437-446 pubmed publisher
Stegmann C, Hochdorfer D, Lieber D, Subramanian N, Stöhr D, Laib Sampaio K, et al. A derivative of platelet-derived growth factor receptor alpha binds to the trimer of human cytomegalovirus and inhibits entry into fibroblasts and endothelial cells. PLoS Pathog. 2017;13:e1006273 pubmed publisher
Han X, Bryson P, Zhao Y, Cinay G, Li S, Guo Y, et al. Masked Chimeric Antigen Receptor for Tumor-Specific Activation. Mol Ther. 2017;25:274-284 pubmed publisher
Leung I, Jarvik N, Sidhu S. A Highly Diverse and Functional Naïve Ubiquitin Variant Library for Generation of Intracellular Affinity Reagents. J Mol Biol. 2017;429:115-127 pubmed publisher
Moores S, Chiu M, Bushey B, Chevalier K, Luistro L, Dorn K, et al. A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor-Resistant Lung Tumors. Cancer Res. 2016;76:3942-53 pubmed publisher
Leung K, Batey S, Rowlands R, Isaac S, Jones P, Drewett V, et al. A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis. Mol Ther. 2015;23:1722-1733 pubmed publisher
Feldwisch J, Tolmachev V, Lendel C, Herne N, Sjöberg A, Larsson B, et al. Design of an optimized scaffold for affibody molecules. J Mol Biol. 2010;398:232-47 pubmed publisher
image
image 1 :
R&D Systems 344-ER-050 image 1
Graph showing bioactivity of Human EGFR protein
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
344-ER
SKU :
344-ER-050
product name :
Recombinant Human EGFR Fc Chimera Protein, CF
description :
The Recombinant Human EGFR Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human EGFR Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.
target :
EGFR
unit size :
50 ug
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
observed molecular weight :
125-145 kDa, under reducing conditions.
theoretical molecular weight :
95.1 kDa (monomer)
gene symbol :
EGFR
details of functionality :
Measured by its ability to bind recombinant human EGF in a functional ELISA with an estimated Kd 8 nM.
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
CAA25240.1
applications :
Binding Activity
product keywords :
344-ER, rhEGF R/Fc, hEGF R, carrier-free, carrier free, 344ER, EGF R/ErbB1, EGF Receptor, Erb1, Receptor Tyrosine Kinase, RTK, EGFR, EGF Receptor, EGFR Kinase, EGFR-kinase, EGF Family, cytokine, cytokines
source :
NS0-derived Recombinant Human EGFR Fc Chimera Protein, CF
extended description :
Analyzed by SEC-MALS
USD :
423
USD 2025 :
428 USD
product details :
Analyzed by SEC-MALS
alt names :
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EC 2.7.10, EC 2.7.10.1, EGF R, epidermal growth factor receptor, epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b)oncogene homolog), ErbB, ErbB1, ERBB1PIG61, HER1, HER-1, mENA, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.