product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human TGF-beta RII Fc Chimera Protein, CF
catalog :
341-BR-050
quantity :
50 ug
price :
526 USD
more info or order :
R&D Systems product webpage
citations: 9
Reference
Kaushansky N, Bakos E, Becker Herman S, Shachar I, Ben Nun A. Circulating Picomolar Levels of CCL2 Downregulate Ongoing Chronic Experimental Autoimmune Encephalomyelitis by Induction of Regulatory Mechanisms. J Immunol. 2019;203:1857-1866 pubmed publisher
Ravi R, Noonan K, Pham V, Bedi R, Zhavoronkov A, Ozerov I, et al. Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy. Nat Commun. 2018;9:741 pubmed publisher
Olsen O, Skjærvik A, Størdal B, Sundan A, Holien T. TGF-? contamination of purified recombinant GDF15. PLoS ONE. 2017;12:e0187349 pubmed publisher
Koehler L, Samsonov S, Rother S, Vogel S, Köhling S, Moeller S, et al. Sulfated Hyaluronan Derivatives Modulate TGF-?1:Receptor Complex Formation: Possible Consequences for TGF-?1 Signaling. Sci Rep. 2017;7:1210 pubmed publisher
Kaushansky N, Eisenstein M, Boura Halfon S, Hansen B, Nielsen C, Milo R, et al. Role of a Novel Human Leukocyte Antigen-DQA1*01:02;DRB1*15:01 Mixed Isotype Heterodimer in the Pathogenesis of "Humanized" Multiple Sclerosis-like Disease. J Biol Chem. 2015;290:15260-78 pubmed publisher
Ballesteros A, Mentink Kane M, Warren J, Kaplan G, Dveksler G. Induction and activation of latent transforming growth factor-β1 are carried out by two distinct domains of pregnancy-specific glycoprotein 1 (PSG1). J Biol Chem. 2015;290:4422-31 pubmed publisher
Mizuuchi Y, Aishima S, Ohuchida K, Shindo K, Fujino M, Hattori M, et al. Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition. Lab Invest. 2015;95:193-206 pubmed publisher
Romero D, Kawano Y, Bengoa N, Walker M, Maltry N, Niehrs C, et al. Downregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF-?/Smad signalling. J Cell Sci. 2013;126:1858-67 pubmed publisher
Lee W, Kang S, Choi J, Lee S, Shah K, Eynon E, et al. Regulating human Th17 cells via differential expression of IL-1 receptor. Blood. 2010;115:530-40 pubmed publisher
product information
brand :
R&D Systems
master code :
341-BR
SKU :
341-BR-050
product name :
Recombinant Human TGF-beta RII Fc Chimera Protein, CF
description :
The Recombinant Human TGF-beta RII Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human TGF-beta RII Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
TGF-beta RII
category :
Proteins and Enzymes
unit sizes :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
59 kDa-66 kDa, reducing conditions
theoretical molecular weight :
41.7 kDa (monomer)
gene symbol :
TGFBR2
details of functionality :
Measured by its binding ability in a functional ELISA. When Recombinant Human TGF-beta 1 (Catalog # 240-B/CF ) is immobilized at 0.5 µg/mL, the concentration of Recombinant Human TGF-beta RII Fc Chimera that produces 50% of the optimal binding response is found to be approximately 6-30 ng/mL.
endotoxin note :
<0.1 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P37173
applications :
Bioactivity
source :
NS0-derived Recombinant Human TGF-beta RII Fc Chimera Protein, CF
USD :
526 USD
alt names :
AAT3, EC 2.7.11, EC 2.7.11.30, FAA3, HNPCC6, LDS1B, LDS2B, MFS2, RIIC, TAAD2, tbetaR-II, TGF-beta receptor type II, TGF-beta receptor type IIB, TGF-beta receptor type-2, TGF-beta type II receptor, TGFbetaRII, TGFbeta-RII, TGFBR2, TGF-bRII, TGFR-2, transforming growth factor beta receptor type IIC, transforming growth factor, beta receptor II (70/80kDa), transforming growth factor, beta receptor II (70/80kDa) isoform 1, transforming growth factor, beta receptor II (70/80kDa) isoform 2, transforming growth factor, beta receptor II (70-80kD), Transforming growth factor-beta receptor type II
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.