Recombinant Human Activin RIIA Fc Chimera Protein | R&D Systems 340-R2 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Activin RIIA Fc Chimera Protein

catalog :

340-R2

quantity :

100 ug

price :

359 USD

citations: 4

Reference
Sakamoto K, Kanematsu Yamaki Y, Kamada Y, Oka M, Ohnishi T, Miwa M, et al. Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology. Biochem Biophys Rep. 2017;11:33-39 pubmed publisher
Kienast Y, Jucknischke U, Scheiblich S, Thier M, de Wouters M, Haas A, et al. Rapid Activation of Bone Morphogenic Protein 9 by Receptor-mediated Displacement of Pro-domains. J Biol Chem. 2016;291:3395-410 pubmed publisher
Sengle G, Ono R, Lyons K, Bachinger H, Sakai L. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol. 2008;381:1025-39 pubmed publisher
Fazzini M, Vallejo G, Colman Lerner A, Trigo R, Campo S, Barañao J, et al. Transforming growth factor beta1 regulates follistatin mRNA expression during in vitro bovine granulosa cell differentiation. J Cell Physiol. 2006;207:40-8 pubmed

product information

brand :

R&D Systems

master code :

340-R2

SKU :

340-R2-100

product name :

Recombinant Human Activin RIIA Fc Chimera Protein

description :

The Recombinant Human Activin RIIA Fc Chimera Protein from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human Activin RIIA Fc Chimera Protein has been validated for the following applications: Bioactivity.

target :

Activin RIIA

category :

Proteins and Enzymes

unit size :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

50 kDa, reducing conditions

theoretical molecular weight :

40 kDa (monomer)

gene symbol :

ACVR2A

details of functionality :

Measured by its ability to inhibit Activin A-induced hemoglobin expression in K562 human chronic myelogenous leukemia cells. Schwall, R.H. et al . (1991) Method Enzymol. 198 :340. Approximately 0.03-0.1 µg/mL of rhActivin RIIA/Fc Chimera will inhibit 50% of the biological response due to 3 ng/mL of rhActivin A.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

catalog number base :

340-R2

accessionNumbers :

P27037

applications :

Bioactivity

source :

Spodoptera frugiperda , Sf 21 (baculovirus)-derived human Activin RIIA protein Human Activin RIIA (Ser25 - Pro134) Accession # P27037 IEGRMD Human IgG1 (Pro100 - Lys330) 6-His tag N-terminus C-terminus

extended description :

A New Activin RIIA is Available! ~2-3x better activity; Lower endotoxin specification; CHO expressed!

2020 USD :

359

2021 USD :

359 USD

product details :

A New Activin RIIA is Available! ~2-3x better activity; Lower endotoxin specification; CHO expressed!

alt names :

activin A receptor, type II, activin A receptor, type IIA, Activin receptor type IIA, activin receptor type-2A, ActivinRIIA, ACTRII, ACTRIIA, ACVR2A, ACVR2ACTR-IIA, AVR2A, EC 2.7.11, EC 2.7.11.30

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.