Recombinant Human Activin RIIA Fc Chimera Protein, CF | R&D Systems 340-R2-100/CF product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Activin RIIA Fc Chimera Protein, CF

catalog :

340-R2-100/CF

quantity :

100 ug

price :

447 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Sakamoto K, Kanematsu Yamaki Y, Kamada Y, Oka M, Ohnishi T, Miwa M, et al. Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology. Biochem Biophys Rep. 2017;11:33-39 pubmed publisher
Yoon B, Chung Y, Yoo S, Kawara K, Kim J, Yoo I, et al. Preferential Induction of the T Cell Auxiliary Signaling Molecule B7-H3 on Synovial Monocytes in Rheumatoid Arthritis. J Biol Chem. 2016;291:4048-57 pubmed publisher
Kienast Y, Jucknischke U, Scheiblich S, Thier M, de Wouters M, Haas A, et al. Rapid Activation of Bone Morphogenic Protein 9 by Receptor-mediated Displacement of Pro-domains. J Biol Chem. 2016;291:3395-410 pubmed publisher
Sengle G, Ono R, Lyons K, Bachinger H, Sakai L. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol. 2008;381:1025-39 pubmed publisher
Fazzini M, Vallejo G, Colman Lerner A, Trigo R, Campo S, Barañao J, et al. Transforming growth factor beta1 regulates follistatin mRNA expression during in vitro bovine granulosa cell differentiation. J Cell Physiol. 2006;207:40-8 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

340-R2/CF

SKU :

340-R2-100/CF

product name :

Recombinant Human Activin RIIA Fc Chimera Protein, CF

Description :

The Recombinant Human Activin RIIA Fc Chimera Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human Activin RIIA Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

Activin RIIA

category :

Proteins and Enzymes

unit size :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

50 kDa, reducing conditions

theoretical molecular weight :

40 kDa (monomer)

gene symbol :

ACVR2A

details of functionality :

Measured by its ability to inhibit Activin A-induced hemoglobin expression in K562 human chronic myelogenous leukemia cells. Schwall, R.H. et al . (1991) Method Enzymol. 198 :340. Approximately 0.03-0.1 µg/mL of rhActivin RIIA/Fc Chimera will inhibit 50% of the biological response due to 3 ng/mL of rhActivin A.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P27037

applications :

Bioactivity

source :

Sf 21 (baculovirus)-derived Recombinant Human Activin RIIA Fc Chimera Protein

extended description :

A New Activin RIIA is Available! ~2-3x better activity; Lower endotoxin specification; CHO expressed!

USD :

447 USD

product details :

A New Activin RIIA is Available! ~2-3x better activity; Lower endotoxin specification; CHO expressed!

alt names :

activin A receptor, type II, activin A receptor, type IIA, Activin receptor type IIA, activin receptor type-2A, ActivinRIIA, ACTRII, ACTRIIA, ACVR2A, ACVR2ACTR-IIA, AVR2A, EC 2.7.11, EC 2.7.11.30

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage