Recombinant Human Activin RIIB Fc Chimera (NS0-expressed) | R&D Systems 339-RB-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Activin RIIB Fc Chimera (NS0-expressed)

catalog :

339-RB-100

quantity :

100 ug

price :

443 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Srole D, Jung G, Waring A, Nemeth E, Ganz T. Characterization of erythroferrone structural domains relevant to its iron-regulatory function. J Biol Chem. 2023;299:105374 pubmed publisher
Walker R, Czepnik M, Goebel E, McCoy J, Vujic A, Cho M, et al. Structural basis for potency differences between GDF8 and GDF11. BMC Biol. 2017;15:19 pubmed publisher
Huang B, Yuan Y, Li T, Ding S, Zhang W, Gu Y, et al. Facilitated receptor-recognition and enhanced bioactivity of bone morphogenetic protein-2 on magnesium-substituted hydroxyapatite surface. Sci Rep. 2016;6:24323 pubmed publisher
Yoon B, Chung Y, Yoo S, Kawara K, Kim J, Yoo I, et al. Preferential Induction of the T Cell Auxiliary Signaling Molecule B7-H3 on Synovial Monocytes in Rheumatoid Arthritis. J Biol Chem. 2016;291:4048-57 pubmed publisher
Kienast Y, Jucknischke U, Scheiblich S, Thier M, de Wouters M, Haas A, et al. Rapid Activation of Bone Morphogenic Protein 9 by Receptor-mediated Displacement of Pro-domains. J Biol Chem. 2016;291:3395-410 pubmed publisher
Sengle G, Ono R, Lyons K, Bachinger H, Sakai L. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol. 2008;381:1025-39 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne brand

catalog number base :

339-RB

SKU :

339-RB-100

product name :

Recombinant Human Activin RIIB Fc Chimera (NS0-expressed)

description :

The Recombinant Human Activin RIIB Fc Chimera (NS0-expressed) from R&D Systems is derived from NS0. The Recombinant Human Activin RIIB Fc Chimera (NS0-expressed) has been validated for the following applications: Bioactivity.

target :

Activin RIIB

unit size :

100 ug

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

observed molecular weight :

60 kDa, reducing conditions

theoretical molecular weight :

41 kDa (monomer)

gene symbol :

ACVR2B

details of functionality :

Measured by its ability to inhibit Activin A-induced hemoglobin expression in K562 human chronic myelogenous leukemia cells. Schwall, R.H. et al . (1991) Method Enzymol. 198 :340. Approximately 0.3-1 µg/mL of rhActivin RIIB/Fc Chimera will inhibit 50% of the biological response due to 3 ng/mL of rhActivin A.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

CAA54671

applications :

Bioactivity

product keywords :

339-RB, rhActivin RIIB/Fc NS0, hActivin RIIB,, 339RB, ActivinRIIB, ActivinRIIB, Activin Receptor IIB, ActRIIB, cytokine, cytokines

source :

NS0-derived Recombinant Human Activin RIIB Fc Chimera (NS0-expressed)

USD :

434

USD 2025 :

443 USD

alt names :

activin A receptor, type IIB, Activin receptor type IIB, activin receptor type-2B, ActivinRIIB, ActR-IIB, ACTRIIB, ACVR2B, EC 2.7.11, EC 2.7.11.30, MGC116908

more info or order :

R&D Systems product webpage