This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human/Mouse/Rat Activin A Protein
catalog :
338-AC
quantity :
10 ug (also 50 ug, 500 ug, 1 mg)
price :
259 USD
citations: 352
Reference
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Yamamoto Y, Ito S, Okuda K, Kimura K. Involvement of activin signal pathway in cyclic apoptosis of the oviductal isthmic epithelium in cows. Theriogenology. 2020;153:143-150 pubmed publisher
Nafria M, Keane P, Ng E, Stanley E, Elefanty A, Bonifer C. Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells. Cell Rep. 2020;31:107691 pubmed publisher
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Loo L, Soetedjo A, Lau H, Ng N, Ghosh S, Nguyen L, et al. BCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells. Cell Death Dis. 2020;11:378 pubmed publisher
Fleischer A, Vallejo Díez S, Martín Fernández J, Sanchez Gilabert A, Castresana M, Del Pozo Á, et al. iPSC-Derived Intestinal Organoids from Cystic Fibrosis Patients Acquire CFTR Activity upon TALEN-Mediated Repair of the p.F508del Mutation. Mol Ther Methods Clin Dev. 2020;17:858-870 pubmed publisher
Thomas A, Castellanos K, Mancinelli G, Xia Y, Bauer J, Yazici C, et al. Activin A Modulates Inflammation in Acute Pancreatitis and Strongly Predicts Severe Disease Independent of Body Mass Index. Clin Transl Gastroenterol. 2020;11:e00152 pubmed publisher
Weyers J, Gunaje J, Van Biber B, Martinson A, Reinecke H, Mahoney W, et al. Sonic Hedgehog upregulation does not enhance the survival and engraftment of stem cell-derived cardiomyocytes in infarcted hearts. PLoS ONE. 2020;15:e0227780 pubmed publisher
Bauer J, Emon M, Staudacher J, Thomas A, Zessner Spitzenberg J, Mancinelli G, et al. Increased stiffness of the tumor microenvironment in colon cancer stimulates cancer associated fibroblast-mediated prometastatic activin A signaling. Sci Rep. 2020;10:50 pubmed publisher
Motazedian A, Bruveris F, Kumar S, Schiesser J, Chen T, Ng E, et al. Multipotent RAG1+ progenitors emerge directly from haemogenic endothelium in human pluripotent stem cell-derived haematopoietic organoids. Nat Cell Biol. 2020;22:60-73 pubmed publisher
Kawai K, Negoro R, Ichikawa M, Yamashita T, Deguchi S, Harada K, et al. Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies. Mol Ther Methods Clin Dev. 2020;17:49-57 pubmed publisher
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Chen M, Maimaitili M, Buchholdt S, Jensen U, Febbraro F, Denham M. Generation of eight human induced pluripotent stem cell lines from Parkinson's disease patients carrying familial mutations. Stem Cell Res. 2019;42:101657 pubmed publisher
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Ge J, Sun H, Li J, Shan Y, Zhao Y, Liao F, et al. Involvement of CHOP in activin A‑induced myeloma NS‑1 cell apoptosis. Oncol Rep. 2019;42:2644-2654 pubmed publisher
Guerriero I, De Angelis M, D Angelo F, Leveque R, Savignano E, Roberto L, et al. Exploring the Molecular Crosstalk between Pancreatic Bud and Mesenchyme in Embryogenesis: Novel Signals Involved. Int J Mol Sci. 2019;20: pubmed publisher
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Luo M, Bai J, Liu B, Yan P, Zuo F, Sun H, et al. H3K18ac Primes Mesendodermal Differentiation upon Nodal Signaling. Stem Cell Reports. 2019;13:642-656 pubmed publisher
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Pecha S, Yorgan K, Röhl M, Geertz B, Hansen A, Weinberger F, et al. Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model. Sci Rep. 2019;9:9831 pubmed publisher
Jung K, Kwon O, Lee M, Lee H, Son Y, Habib O, et al. Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells. J Clin Med. 2019;8: pubmed publisher
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Jin Q, Qiao C, Li J, Xiao B, Li J, Xiao X. A GDF11/myostatin inhibitor, GDF11 propeptide-Fc, increases skeletal muscle mass and improves muscle strength in dystrophic mdx mice. Skelet Muscle. 2019;9:16 pubmed publisher
Sharon N, Vanderhooft J, Straubhaar J, Mueller J, Chawla R, Zhou Q, et al. Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development. Cell Rep. 2019;27:2281-2291.e5 pubmed publisher
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Minami T, Ishii T, Yasuchika K, Fukumitsu K, Ogiso S, Miyauchi Y, et al. Novel hybrid three-dimensional artificial liver using human induced pluripotent stem cells and a rat decellularized liver scaffold. Regen Ther. 2019;10:127-133 pubmed publisher
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Kim J, Kim J, Sutikno L, Lee S, Jin D, Hong Y, et al. Identification of the minimum region of flatfish myostatin propeptide (Pep45-65) for myostatin inhibition and its potential to enhance muscle growth and performance in animals. PLoS ONE. 2019;14:e0215298 pubmed publisher
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Ito K, Matsuura K, Mihara Y, Sakamoto Y, Hasegawa K, Kokudo N, et al. Delivery of pancreatic digestive enzymes into the gastrointestinal tract by pancreatic exocrine tissue transplant. Sci Rep. 2019;9:5922 pubmed publisher
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Wang X, Sterr M, Ansarullah -, Burtscher I, Böttcher A, Beckenbauer J, et al. Point mutations in the PDX1 transactivation domain impair human β-cell development and function. Mol Metab. 2019;24:80-97 pubmed publisher
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Toba Y, Kiso A, Nakamae S, Sakurai F, Takayama K, Mizuguchi H. FGF signal is not required for hepatoblast differentiation of human iPS cells. Sci Rep. 2019;9:3713 pubmed publisher
Colunga T, Hayworth M, Kreß S, Reynolds D, Chen L, Nazor K, et al. Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair. Cell Rep. 2019;26:2566-2579.e10 pubmed publisher
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Rentsch P, Stayte S, Morris G, Vissel B. Time dependent degeneration of the nigrostriatal tract in mice with 6-OHDA lesioned medial forebrain bundle and the effect of activin A on L-Dopa induced dyskinesia. BMC Neurosci. 2019;20:5 pubmed publisher
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Montel Hagen A, Seet C, Li S, Chick B, Zhu Y, Chang P, et al. Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 2019;24:376-389.e8 pubmed publisher
Lin T, Chien Y, Lin Y, Wang M, Yarmishyn A, Yang Y, et al. Establishing Liposome-Immobilized Dexamethasone-Releasing PDMS Membrane for the Cultivation of Retinal Pigment Epithelial Cells and Suppression of Neovascularization. Int J Mol Sci. 2019;20: pubmed publisher
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Lin Y, Chien Y, Chuang J, Chang C, Yang Y, Lai Y, et al. Development of a Graphene Oxide-Incorporated Polydimethylsiloxane Membrane with Hexagonal Micropillars. Int J Mol Sci. 2018;19: pubmed publisher
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Miyagi Shiohira C, Nakashima Y, Kobayashi N, Saitoh I, Watanabe M, Noguchi H. Characterization of induced tissue-specific stem cells from pancreas by a synthetic self-replicative RNA. Sci Rep. 2018;8:12341 pubmed publisher
Spangler A, Su E, Craft A, Cahan P. A single cell transcriptional portrait of embryoid body differentiation and comparison to progenitors of the developing embryo. Stem Cell Res. 2018;31:201-215 pubmed publisher
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Magro Lopez E, Palmer C, Manso J, Liste I, Zambrano A. Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids. Stem Cell Res Ther. 2018;9:186 pubmed publisher
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Workman M, Gleeson J, Troisi E, Estrada H, Kerns S, HINOJOSA C, et al. Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips. Cell Mol Gastroenterol Hepatol. 2018;5:669-677.e2 pubmed publisher
Zambelli F, Mertens J, Dziedzicka D, Sterckx J, Markouli C, Keller A, et al. Random Mutagenesis, Clonal Events, and Embryonic or Somatic Origin Determine the mtDNA Variant Type and Load in Human Pluripotent Stem Cells. Stem Cell Reports. 2018;11:102-114 pubmed publisher
Russell R, Fu Y, Liu Y, Maye P. Inverse agonism of retinoic acid receptors directs epiblast cells into the paraxial mesoderm lineage. Stem Cell Res. 2018;30:85-95 pubmed publisher
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Schöbel A, Rösch K, Herker E. Functional innate immunity restricts Hepatitis C Virus infection in induced pluripotent stem cell-derived hepatocytes. Sci Rep. 2018;8:3893 pubmed publisher
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Yamashita T, Takayama K, Sakurai F, Mizuguchi H. Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells. Biochem Biophys Res Commun. 2018;496:1269-1275 pubmed publisher
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Merfeld Clauss S, Lu H, Wu X, March K, Traktuev D. Hypoxia-induced activin A diminishes endothelial cell vasculogenic activity. J Cell Mol Med. 2018;22:173-184 pubmed publisher
Fagg W, Liu N, Yang M, Cheng K, Chung E, Kim J, et al. Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver. Cell Transplant. 2017;26:1868-1877 pubmed publisher
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Kotaka M, Toyoda T, Yasuda K, Kitano Y, Okada C, Ohta A, et al. Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells. Sci Rep. 2017;7:16734 pubmed publisher
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product information
brand :
R&D Systems
master code :
338-AC
SKU :
338-AC-010
product name :
Recombinant Human/Mouse/Rat Activin A Protein
description :
The Recombinant Human/Mouse/Rat Activin A Protein from R&D Systems is derived from CHO. The Recombinant Human/Mouse/Rat Activin A Protein has been validated for the following applications: Bioactivity.
target :
Activin A
category :
Proteins and Enzymes
unit size :
10 ug (also 50 ug, 500 ug, 1 mg)
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE with silver staining.
species :
Human, Mouse, Rat
observed molecular weight :
14 kDa, reducing conditions 24 kDa, non-reducing conditions
theoretical molecular weight :
13 kDa (monomer)
gene symbol :
INHBA
details of functionality :
Measured by its ability to induce hemoglobin expression in K562 human chronic myelogenous leukemia cells. Schwall, R.H. et al . (1991) Method Enzymol. 198 :340. The ED50 for this effect is 0.2-1.2 ng/mL. The specific activity of Recombinant Human/Mouse/Rat Activin A is approximately 1 IU/µg, which is calibrated against human Activin A WHO International Standard (NIBSC code: 91/626).
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
catalog number base :
338-AC
accessionNumbers :
P08476
applications :
Bioactivity
source :
Chinese Hamster Ovary cell line, CHO-derived Activin A protein Gly311-Ser426
extended description :
CHO derived
2020 USD :
259
2021 USD :
259 USD
product details :
CHO derived
alt names :
activin AB alpha polypeptide, Activin beta-A chain, erythroid differentiation factor, Erythroid differentiation protein, follicle-stimulating hormone-releasing protein, FSH-releasing protein, inhibin beta A chain, inhibin beta A subunit, Inhibin, beta-1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.