Zhao C, Inada Y, Motoike S, Kamiya D, Hino K, Ikeya M. BMP-9 mediates fibroproliferation in fibrodysplasia ossificans progressiva through TGF-β signaling. EMBO Mol Med. 2025;17:112-128 pubmed publisher

Hogrebe N, Schmidt M, Augsornworawat P, Gale S, Shunkarova M, Millman J. Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation. bioRxiv. 2025;: pubmed publisher

Bisson J, Gordillo M, Kumar R, de Silva N, Yang E, Banks K, et al. GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis. bioRxiv. 2025;: pubmed publisher

Yoo S, Yuan X, Engstrom C, Chang P, Li S, Lathrop L, et al. Stage-specific CAR-mediated signaling generates naïve-like, TCR-null CAR T cells from induced pluripotent stem cells. bioRxiv. 2024;: pubmed publisher

Kelley A, Shunkarova M, Maestas M, Gale S, Hogrebe N, Millman J. Controlling human stem cell-derived islet composition using magnetic sorting. bioRxiv. 2024;: pubmed publisher

Saito Diaz K, Saini T, Patel A, James C, Thomas K, Knight T, et al. Laminin β4 is required for the development of human peripheral sensory neurons. bioRxiv. 2024;: pubmed publisher

Lim A, Pouyabahar D, Ashraf M, Huang K, Lohbihler M, Murareanu B, et al. Single-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes. Nat Commun. 2024;15:10206 pubmed publisher

Hill M, Simonson B, Roselli C, Xiao L, Herndon C, Chaffin M, et al. Large-scale single-nuclei profiling identifies role for ATRNL1 in atrial fibrillation. Nat Commun. 2024;15:10002 pubmed publisher

Kim D, Lim H, Youn J, Park T, Kim D. Scalable production of uniform and mature organoids in a 3D geometrically-engineered permeable membrane. Nat Commun. 2024;15:9420 pubmed publisher

Wei X, Qiu J, Lai R, Wei T, Lin Z, Huang S, et al. A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration. Cell Stem Cell. 2024;31:1813-1830.e8 pubmed publisher

Zhang F, Cui X, Yang K, Guo R, Zhu L, Zhao W, et al. Activin A inhibits the migration of human lung adenocarcinoma A549 cells induced by EGF. Int Immunopharmacol. 2024;142:113170 pubmed publisher

Lekkala V, Shrestha S, Qaryoute A, Dhinoja S, Acharya P, Raheem A, et al. Enhanced Maturity and Functionality of Vascularized Human Liver Organoids through 3D Bioprinting and Pillar Plate Culture. bioRxiv. 2024;: pubmed publisher

Kent G, Atkins M, Lung B, Nikitina A, Fernandes I, Kwan J, et al. Human liver sinusoidal endothelial cells support the development of functional human pluripotent stem cell-derived Kupffer cells. Cell Rep. 2024;43:114629 pubmed publisher

Tereshchenko Y, Petkov S, Behr R. The Efficiency of In Vitro Differentiation of Primate iPSCs into Cardiomyocytes Depending on Their Cell Seeding Density and Cell Line Specificity. Int J Mol Sci. 2024;25: pubmed publisher

Modic M, Kuret K, Steinhauser S, Faraway R, van Genderen E, Ruiz de Los Mozos I, et al. Poised PABP-RNA hubs implement signal-dependent mRNA decay in development. Nat Struct Mol Biol. 2024;31:1439-1447 pubmed publisher

Jo K, Liu Z, Patel G, Yu Z, Yao L, Teague S, et al. Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids. bioRxiv. 2024;: pubmed publisher

Landau S, Zhao Y, Hamidzada H, Kent G, Okhovatian S, Lu R, et al. Primitive macrophages enable long-term vascularization of human heart-on-a-chip platforms. Cell Stem Cell. 2024;31:1222-1238.e10 pubmed publisher

x130 x15f x, Wang X, Reddy J, Min Y, Yilmaz E, Bhattarai P, et al. Gliovascular transcriptional perturbations in Alzheimer's disease reveal molecular mechanisms of blood brain barrier dysfunction. Nat Commun. 2024;15:4758 pubmed publisher

Wang S, Leng L, Wang Q, Gu Y, Li J, An Y, et al. A single-cell transcriptome atlas of human euploid and aneuploid blastocysts. Nat Genet. 2024;56:1468-1481 pubmed publisher

Fujita S, Plianchaisuk A, Deguchi S, Ito H, Nao N, Wang L, et al. Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236. EBioMedicine. 2024;104:105181 pubmed publisher

O Connell A, Raveenthiraraj S, Oliveira L, Adegboye C, Dasuri V, Qi W, et al. WNT2B Deficiency Causes Enhanced Susceptibility to Colitis Due to Increased Inflammatory Cytokine Production. Cell Mol Gastroenterol Hepatol. 2024;18:101349 pubmed publisher

Namoto K, Baader C, Orsini V, Landshammer A, Breuer E, Dinh K, et al. NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo. Cell Stem Cell. 2024;31:554-569.e17 pubmed publisher

Farahani E, Reinert L, Narita R, Serrero M, Skouboe M, van der Horst D, et al. The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation. Cell Rep. 2024;43:113792 pubmed publisher

Johnson B, Cosson M, Tsansizi L, Holmes T, Gilmore T, Hampton K, et al. Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes. Cell Rep. 2024;43:113668 pubmed publisher

Cota P, Caliskan x, Bastidas Ponce A, Jing C, Jaki J, Saber L, et al. Insulin regulates human pancreatic endocrine cell differentiation in vitro. Mol Metab. 2024;79:101853 pubmed publisher

Isaac E, Berg D, Pfeffer P. Using extended growth of cattle embryos in culture to gain insights into bovine developmental events on embryonic days 8 to 10. Theriogenology. 2024;214:10-20 pubmed publisher

Marcoux P, Hwang J, Desterke C, Imeri J, Bennaceur Griscelli A, Turhan A. Modeling RET-Rearranged Non-Small Cell Lung Cancer (NSCLC): Generation of Lung Progenitor Cells (LPCs) from Patient-Derived Induced Pluripotent Stem Cells (iPSCs). Cells. 2023;12: pubmed publisher

Tao Y, Li X, Dong Q, Kong L, Petersen A, Yan Y, et al. Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells. Nat Biotechnol. 2023;: pubmed publisher

Chen Y, Chen Y, Li Q, Liu H, Han J, Zhang H, et al. Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells. Cell Rep. 2023;42:113308 pubmed publisher

Lyu X, Rowley M, Kulik M, Dalton S, Corces V. Regulation of CTCF loop formation during pancreatic cell differentiation. Nat Commun. 2023;14:6314 pubmed publisher

Yang Y, Lin C, Ma H, Xie J, Kaplan F, Gao G, et al. AAV-Mediated Targeting of the Activin A-ACVR1R206H Signaling in Fibrodysplasia Ossificans Progressiva. Biomolecules. 2023;13: pubmed publisher

Shimizu K, Kikuta J, Ohta Y, Uchida Y, Miyamoto Y, Morimoto A, et al. Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction. Nat Commun. 2023;14:4417 pubmed publisher

Bourhill T, Rohani L, Kumar M, Bose P, Rancourt D, Johnston R. Modulation of Reoviral Cytolysis (II): Cellular Stemness. Viruses. 2023;15: pubmed publisher

Mullari M, Fossat N, Skotte N, Asenjo Martinez A, Humphreys D, Bukh J, et al. Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington's disease. Nat Commun. 2023;14:4348 pubmed publisher

Overeem A, Chang Y, Moustakas I, Roelse C, Hillenius S, Helm T, et al. Efficient and scalable generation of primordial germ cells in 2D culture using basement membrane extract overlay. Cell Rep Methods. 2023;3:100488 pubmed publisher

L xe1 zaro J, Costanzo M, Sanaki Matsumiya M, Girardot C, Hayashi M, Hayashi K, et al. A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals. Cell Stem Cell. 2023;30:938-949.e7 pubmed publisher

Alber A, Marquez H, Ma L, Kwong G, Thapa B, Villacorta Martin C, et al. Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme. Nat Commun. 2023;14:3488 pubmed publisher

Matkovic Leko I, Schneider R, Thimraj T, Schrode N, Beitler D, Liu H, et al. A distal lung organoid model to study interstitial lung disease, viral infection and human lung development. Nat Protoc. 2023;18:2283-2312 pubmed publisher

Li S, Wang C, Montel Hagen A, Chen H, Lopez S, Zhou O, et al. Strength of CAR signaling determines T cell versus ILC differentiation from pluripotent stem cells. Cell Rep. 2023;42:112241 pubmed publisher

Dicks A, Maksaev G, Harissa Z, Savadipour A, Tang R, Steward N, et al. Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes. elife. 2023;12: pubmed publisher

Ugur E, de la Porte A, Qin W, Bultmann S, Ivanova A, Drukker M, et al. Comprehensive chromatin proteomics resolves functional phases of pluripotency and identifies changes in regulatory components. Nucleic Acids Res. 2023;51:2671-2690 pubmed publisher

Choi E, Vodnala M, Saini P, Anugula S, Zerbato M, Ho J, et al. Transcription factor SOX15 regulates stem cell pluripotency and promotes neural fate during differentiation by activating the neurogenic gene Hes5. J Biol Chem. 2023;299:102996 pubmed publisher

Landshammer A, Bolondi A, Kretzmer H, Much C, Buschow R, Rose A, et al. T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation. elife. 2023;12: pubmed publisher

Madrigal P, Deng S, Feng Y, Militi S, Goh K, Nibhani R, et al. Epigenetic and transcriptional regulations prime cell fate before division during human pluripotent stem cell differentiation. Nat Commun. 2023;14:405 pubmed publisher

Shah P, Keough K, Gjoni K, Santini G, Abdill R, Wickramasinghe N, et al. An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype. Genome Biol. 2023;24:16 pubmed publisher

Taniguchi S, Matsui T, Kimura K, Funaki S, Miyamoto Y, Uchida Y, et al. In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma. Nat Commun. 2023;14:143 pubmed publisher

Liu Q, Liu Z, Gu H, Ge Y, Wu X, Zuo F, et al. Comparative study of differentiating human pluripotent stem cells into vascular smooth muscle cells in hydrogel-based culture methods. Regen Ther. 2023;22:39-49 pubmed publisher

Stevens A, Harris A, Gerdts J, Kim K, Trentesaux C, Ramirez J, et al. Programming multicellular assembly with synthetic cell adhesion molecules. Nature. 2023;614:144-152 pubmed publisher

Reader K, John McHaffie S, Zellhuber McMillan S, Jowett T, Mottershead D, Cunliffe H, et al. Activin B and Activin C Have Opposing Effects on Prostate Cancer Progression and Cell Growth. Cancers (Basel). 2022;15: pubmed publisher

Chen F, Zhu X. Activin A Reduces Porcine Granulosa Cells Apoptosis via ERβ-Dependent ROS Modulation. Vet Sci. 2022;9: pubmed publisher

Triolo T, Matuschek J, Castro Gutierrez R, Shilleh A, Williams S, Hansen M, et al. Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity. Cells. 2022;11: pubmed publisher

Karabiyik Acar x, Nozhatzadeh G, Tuncer A, Torun K xf6 se G, Hacihasano x11f lu E, Sahin F, et al. Production of parathyroid-like cells from thyroid stem cells in co-culture environment. Medicine (Baltimore). 2022;101:e32009 pubmed publisher

Shang D, Lan T, Wang Y, Li X, Liu Q, Dong H, et al. PGCLCs of human 45,XO reveal pathogenetic pathways of neurocognitive and psychosocial disorders. Cell Biosci. 2022;12:194 pubmed publisher

Watts J, Grunseich C, Rodriguez Y, Liu Y, Li D, Burdick J, et al. A common transcriptional mechanism involving R-loop and RNA abasic site regulates an enhancer RNA of APOE. Nucleic Acids Res. 2022;50:12497-12514 pubmed publisher

Bas Crist xf3 bal Men xe9 ndez A, Du Z, van den Bosch T, Othman A, Gaio N, Silvestri C, et al. Creating a kidney organoid-vasculature interaction model using a novel organ-on-chip system. Sci Rep. 2022;12:20699 pubmed publisher

Florentino R, Morita K, Haep N, Motomura T, Díaz Aragon R, Faccioli L, et al. Biofabrication of synthetic human liver tissue with advanced programmable functions. iScience. 2022;25:105503 pubmed publisher

Ng E, Kady N, Hu J, Dave A, Jiang Z, Pei J, et al. Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration. Cells. 2022;11: pubmed publisher

Lesage R, Ferrao Blanco M, Narcisi R, Welting T, van Osch G, Geris L. An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis. BMC Biol. 2022;20:253 pubmed publisher

Raad S, David A, Sagniez M, Par xe9 B, Orfi Z, Dumont N, et al. iPSCs derived from esophageal atresia patients reveal SOX2 dysregulation at the anterior foregut stage. Dis Model Mech. 2022;15: pubmed publisher

Yang Y, Kim J, Xie J, Chaugule S, Lin C, Ma H, et al. Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery. Nat Commun. 2022;13:6175 pubmed publisher

Han Y, Tan L, Zhou T, Yang L, Carrau L, Lacko L, et al. A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. Cell Stem Cell. 2022;29:1475-1490.e6 pubmed publisher

Beucher A, Miguel Escalada I, Balboa D, De Vas M, Maestro M, García Hurtado J, et al. The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A. Nat Cell Biol. 2022;24:1528-1540 pubmed publisher

Wang Z, Fan R, Russo A, Cernilogar F, Nuber A, Schirge S, et al. Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm. Nat Commun. 2022;13:5447 pubmed publisher

Yang D, Gomez Garcia J, Funakoshi S, Tran T, Fernandes I, Bader G, et al. Modeling human multi-lineage heart field development with pluripotent stem cells. Cell Stem Cell. 2022;29:1382-1401.e8 pubmed publisher

R xf6 ssig A, Hill K, N xf6 renberg W, Weidenbach S, Zierler S, Schaefer M, et al. Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7. Cell Calcium. 2022;106:102640 pubmed publisher

Kim S, Lee M, Choi K, Jeong J, Lee D, Oh J, et al. Species-Specific Enhancer Activity of OCT4 in Porcine Pluripotency: The Porcine OCT4 Reporter System Could Monitor Pluripotency in Porcine Embryo Development and Embryonic Stem Cells. Stem Cells Int. 2022;2022:6337532 pubmed publisher

xc1 vila Gonz xe1 lez D, Portillo W, Barrag xe1 n xc1 lvarez C, Hernández Montes G, Flores Garza E, Molina Hern xe1 ndez A, et al. The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells. elife. 2022;11: pubmed publisher

Pulcrano S, De Gregorio R, De Sanctis C, Lahti L, Perrone Capano C, Ponti D, et al. Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation. Int J Mol Sci. 2022;23: pubmed publisher

Tan K, Wilkinson M. Regulation of both transcription and RNA turnover contribute to germline specification. Nucleic Acids Res. 2022;50:7310-7325 pubmed publisher

Tsujisaka Y, Hatani T, Okubo C, Ito R, Kimura A, Narita M, et al. Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting. Stem Cell Reports. 2022;17:1772-1785 pubmed publisher

Marvin D, You L, Bornes L, Van Dinther M, Peters N, Dang H, et al. Dynamic Visualization of TGF-β/SMAD3 Transcriptional Responses in Single Living Cells. Cancers (Basel). 2022;14: pubmed publisher

Kadokawa H, Yoshino R, Saito R, Hirokawa T. Chemosynthetic ethanolamine plasmalogen stimulates gonadotropin secretion from bovine gonadotrophs by acting as a potential GPR61 agonist. Anim Reprod Sci. 2022;241:106992 pubmed publisher

Nair A, Traurig M, Sutherland J, Muller Y, Grellinger E, Saporito L, et al. Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians. Cells. 2022;11: pubmed publisher

Samanta M, Gayen S, Harris C, Maclary E, Murata Nakamura Y, Malcore R, et al. Activation of Xist by an evolutionarily conserved function of KDM5C demethylase. Nat Commun. 2022;13:2602 pubmed publisher

Fagg W, Liu N, Braunschweig U, Pereira de Castro K, Chen X, Ditmars F, et al. Definition of germ layer cell lineage alternative splicing programs reveals a critical role for Quaking in specifying cardiac cell fate. Nucleic Acids Res. 2022;50:5313-5334 pubmed publisher

Cloutier M, Kumar S, Buttigieg E, Keller L, Lee B, Williams A, et al. Preventing erosion of X-chromosome inactivation in human embryonic stem cells. Nat Commun. 2022;13:2516 pubmed publisher

Aykul S, Huang L, Wang L, Das N, Reisman S, Ray Y, et al. Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1. J Clin Invest. 2022;132: pubmed publisher

Lees Shepard J, Stoessel S, Chandler J, Bouchard K, Bento P, Apuzzo L, et al. An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro-adipogenic progenitors in fibrodysplasia ossificans progressiva mice. J Clin Invest. 2022;132: pubmed publisher

Luff S, Creamer J, Valsoni S, Dege C, Scarf xf2 R, Dacunto A, et al. Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells. Nat Cell Biol. 2022;24:616-624 pubmed publisher

Kojima H, Yagi H, Kushige H, Toda Y, Takayama K, Masuda S, et al. Decellularized Organ-Derived Scaffold Is a Promising Carrier for Human Induced Pluripotent Stem Cells-Derived Hepatocytes. Cells. 2022;11: pubmed publisher

Li J, Liu X, Yang Q, Huang J, Zhou W, Tan Z, et al. The effect of docetaxel on retinal pigment epithelial cells. Toxicol Rep. 2022;9:670-678 pubmed publisher

Calvanese V, Capellera Garcia S, Ma F, Fares I, Liebscher S, Ng E, et al. Mapping human haematopoietic stem cells from haemogenic endothelium to birth. Nature. 2022;604:534-540 pubmed publisher

Gage B, Merlin S, Olgasi C, Follenzi A, Keller G. Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors. Cell Rep. 2022;39:110621 pubmed publisher

Jiang C, Goyal Y, Jain N, Wang Q, Truitt R, Cot xe9 A, et al. Cell type determination for cardiac differentiation occurs soon after seeding of human-induced pluripotent stem cells. Genome Biol. 2022;23:90 pubmed publisher

Kim S, Min S, Choi Y, Jo S, Jung J, Han K, et al. Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids. Nat Commun. 2022;13:1692 pubmed publisher

Zhu Y, Prata L, Gerdes E, Netto J, Pirtskhalava T, Giorgadze N, et al. Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans. EBioMedicine. 2022;77:103912 pubmed publisher

Wang Z, McWilliams Koeppen H, Reza H, Ostberg J, Chen W, Wang X, et al. 3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells. Cell Stem Cell. 2022;29:515-527.e8 pubmed publisher

Kim H, Song B, Park S, Choi S, Moon H, Hwang K, et al. Ultraefficient extracellular vesicle-guided direct reprogramming of fibroblasts into functional cardiomyocytes. Sci Adv. 2022;8:eabj6621 pubmed publisher

Kim H, Seok J, Jung S, Lee M, Tran A, Yeo S, et al. Development of Surgically Transplantable Parathyroid Hormone-Releasing Microbeads. Biomedicines. 2022;10: pubmed publisher

Capeling M, Huang S, Childs C, Wu J, Tsai Y, Wu A, et al. Suspension culture promotes serosal mesothelial development in human intestinal organoids. Cell Rep. 2022;38:110379 pubmed publisher

Zhao K, Shi Y, Yu J, Yu L, Mael A, Li Y, et al. Intracameral Microimaging of Maturation of Human iPSC Derivatives into Islet Endocrine Cells. Cell Transplant. 2022;31:9636897211066508 pubmed publisher

Li X, Morgan C, Goff L, Doetzlhofer A. Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea. Sci Adv. 2022;8:eabj7651 pubmed publisher

Raggi C, M Callum M, Pham Q, Gaub P, Selleri S, Baratang N, et al. Leveraging interacting signaling pathways to robustly improve the quality and yield of human pluripotent stem cell-derived hepatoblasts and hepatocytes. Stem Cell Reports. 2022;17:584-598 pubmed publisher

Tada T, Ohnishi H, Yamamoto N, Kuwata F, Hayashi Y, Okuyama H, et al. Transplantation of a human induced pluripotent stem cell-derived airway epithelial cell sheet into the middle ear of rats. Regen Ther. 2022;19:77-87 pubmed publisher

Kim J, Park S, Oh S, Nam Y, Choi Y, Choi Y, et al. Density-Dependent Differentiation of Tonsil-Derived Mesenchymal Stem Cells into Parathyroid-Hormone-Releasing Cells. Int J Mol Sci. 2022;23: pubmed publisher

Xian H, Blanco C, Bonham K, Snodgrass H. Kinase inhibitor-induced cardiotoxicity assessed in vitro with human pluripotent stem cell derived cardiomyocytes. Toxicol Appl Pharmacol. 2022;437:115886 pubmed publisher

Hu X, Wang H, Tian G, Hou C, Xu B, Zhao X, et al. Offspring production of haploid spermatid-like cells derived from mouse female germline stem cells with chromatin condensation. Cell Biosci. 2022;12:5 pubmed publisher

Ungricht R, Guibbal L, Lasbennes M, Orsini V, Beibel M, Waldt A, et al. Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis. Cell Stem Cell. 2022;29:160-175.e7 pubmed publisher

Jiang L, Liang J, Huang W, Ma J, Park K, Wu Z, et al. CRISPR activation of endogenous genes reprograms fibroblasts into cardiovascular progenitor cells for myocardial infarction therapy. Mol Ther. 2022;30:54-74 pubmed publisher

Xia S, Bozoky Z, Di Paola M, Laselva O, Ahmadi S, Jiang J, et al. High-Throughput Functional Analysis of CFTR and Other Apically Localized Proteins in iPSC-Derived Human Intestinal Organoids. Cells. 2021;10: pubmed publisher

Sharma R, George A, Nimmagadda M, Ortolan D, Karla B, Qureshy Z, et al. Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model. Nat Commun. 2021;12:7293 pubmed publisher

Chesnokova V, Zonis S, Apostolou A, Estrada H, Knott S, Wawrowsky K, et al. Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage. Cell Rep. 2021;37:110068 pubmed publisher

Brulé E, Wang Y, Li Y, Lin Y, Zhou X, Ongaro L, et al. TGFBR3L is an inhibin B co-receptor that regulates female fertility. Sci Adv. 2021;7:eabl4391 pubmed publisher

Lan Y, Banks K, Pan H, Verma N, Dixon G, Zhou T, et al. Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation. Cell Rep. 2021;37:110095 pubmed publisher

Xu F, Deng C, Ren Z, Sun L, Meng Y, Liu W, et al. Lysophosphatidic acid shifts metabolic and transcriptional landscapes to induce a distinct cellular state in human pluripotent stem cells. Cell Rep. 2021;37:110063 pubmed publisher

de Souza A, Bressan F, Pieri N, Botigelli R, Revay T, Haddad S, et al. Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients. Cells. 2021;10: pubmed publisher

Gil Recio C, Montori S, Al Demour S, Ababneh M, Ferr xe9 s Padr xf3 E, Martí C, et al. Chemically Defined Conditions Mediate an Efficient Induction of Dental Pulp Pluripotent-Like Stem Cells into Hepatocyte-Like Cells. Stem Cells Int. 2021;2021:5212852 pubmed publisher

Geusz R, Wang A, Lam D, Vinckier N, Alysandratos K, Roberts D, et al. Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors. Nat Commun. 2021;12:6636 pubmed publisher

Hernandez J, Wang X, Vazquez Segoviano M, Lopez Marfil M, Sobral Reyes M, Moran Horowich A, et al. A tissue-bioengineering strategy for modeling rare human kidney diseases in vivo. Nat Commun. 2021;12:6496 pubmed publisher

Valcourt J, Huang R, Kundu S, Venkatasubramanian D, Kingston R, Ramanathan S. Modulating mesendoderm competence during human germ layer differentiation. Cell Rep. 2021;37:109990 pubmed publisher

Schaniel C, Dhanan P, Hu B, Xiong Y, Raghunandan T, Gonzalez D, et al. A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals. Stem Cell Reports. 2021;16:3036-3049 pubmed publisher

Duan X, Tang X, Nair M, Zhang T, Qiu Y, Zhang W, et al. An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection. Cell Rep. 2021;37:109920 pubmed publisher

Le M, Takahi M, Ohnuma K. Auto/paracrine factors and early Wnt inhibition promote cardiomyocyte differentiation from human induced pluripotent stem cells at initial low cell density. Sci Rep. 2021;11:21426 pubmed publisher

Hosaka N, Kanda S, Shimono T, Nishiyama T. Induction of γδT cells from HSC-enriched BMCs co-cultured with iPSC-derived thymic epithelial cells. J Cell Mol Med. 2021;25:10604-10613 pubmed publisher

Lim J, Sakai E, Sakurai F, Mizuguchi H. miR-27b antagonizes BMP signaling in early differentiation of human induced pluripotent stem cells. Sci Rep. 2021;11:19820 pubmed publisher

Aghazadeh Y, Poon F, Sarangi F, Wong F, Khan S, Sun X, et al. Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models. Cell Stem Cell. 2021;28:1936-1949.e8 pubmed publisher

Wei M, Zhang J, Liu J, Zhao C, Cao S, Yan X, et al. Derivation of Mouse Parthenogenetic Advanced Stem Cells. Int J Mol Sci. 2021;22: pubmed publisher

Martin Inaraja M, Ferreira M, Taelman J, Eguizabal C, Chuva de Sousa Lopes S. Improving In Vitro Culture of Human Male Fetal Germ Cells. Cells. 2021;10: pubmed publisher

Parent A, Faleo G, Chavez J, SAXTON M, Berrios D, Kerper N, et al. Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection. Cell Rep. 2021;36:109538 pubmed publisher

Hogrebe N, Maxwell K, Augsornworawat P, Millman J. Generation of insulin-producing pancreatic β cells from multiple human stem cell lines. Nat Protoc. 2021;16:4109-4143 pubmed publisher

Grancharova T, Gerbin K, Rosenberg A, Roco C, Arakaki J, DeLizo C, et al. A comprehensive analysis of gene expression changes in a high replicate and open-source dataset of differentiating hiPSC-derived cardiomyocytes. Sci Rep. 2021;11:15845 pubmed publisher

Lee M, Lee S, Jung C, Son Y, Ryu J, Jung K, et al. Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells. Nat Commun. 2021;12:4492 pubmed publisher

Sattler K, El Battrawy I, Cyganek L, Lang S, Lan H, Li X, et al. TRPV1 activation and internalization is part of the LPS-induced inflammation in human iPSC-derived cardiomyocytes. Sci Rep. 2021;11:14689 pubmed publisher

Degani N, Lubelsky Y, Perry R, Ainbinder E, Ulitsky I. Highly conserved and cis-acting lncRNAs produced from paralogous regions in the center of HOXA and HOXB clusters in the endoderm lineage. PLoS Genet. 2021;17:e1009681 pubmed publisher

Grow E, Weaver B, Smith C, Guo J, Stein P, Shadle S, et al. p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models. Nat Genet. 2021;53:1207-1220 pubmed publisher

Djidrovski I, Georgiou M, Hughes G, Patterson E, Casas Sánchez A, Pennington S, et al. SARS-CoV-2 infects an upper airway model derived from induced pluripotent stem cells. Stem Cells. 2021;39:1310-1321 pubmed publisher

Iseoka H, Miyagawa S, Sakai Y, Sawa Y. Cardiac fibrosis models using human induced pluripotent stem cell-derived cardiac tissues allow anti-fibrotic drug screening in vitro. Stem Cell Res. 2021;54:102420 pubmed publisher

Kwon O, Jung K, Lee K, Son Y, Lee H, Kim J, et al. The development of a functional human small intestinal epithelium model for drug absorption. Sci Adv. 2021;7: pubmed publisher

Mishra S, Taelman J, Chang Y, Boel A, De Sutter P, Heindryckx B, et al. Sex-Specific Isolation and Propagation of Human Premeiotic Fetal Germ Cells and Germ Cell-Like Cells. Cells. 2021;10: pubmed publisher

Zahmatkesh E, Ghanian M, Zarkesh I, Farzaneh Z, Halvaei M, Heydari Z, et al. Tissue-Specific Microparticles Improve Organoid Microenvironment for Efficient Maturation of Pluripotent Stem-Cell-Derived Hepatocytes. Cells. 2021;10: pubmed publisher

Soto D, Navarro M, Zheng C, Halstead M, Zhou C, Guiltinan C, et al. Simplification of culture conditions and feeder-free expansion of bovine embryonic stem cells. Sci Rep. 2021;11:11045 pubmed publisher

Funakoshi S, Fernandes I, Mastikhina O, Wilkinson D, Tran T, Dhahri W, et al. Generation of mature compact ventricular cardiomyocytes from human pluripotent stem cells. Nat Commun. 2021;12:3155 pubmed publisher

Huang M, Liao Z, Li X, Yang Z, Fan X, Li Y, et al. Effects of Antiarrhythmic Drugs on hERG Gating in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1. Front Pharmacol. 2021;12:675003 pubmed publisher

Ruf Zamojski F, Zhang Z, Zamojski M, Smith G, Mendelev N, Liu H, et al. Single nucleus multi-omics regulatory landscape of the murine pituitary. Nat Commun. 2021;12:2677 pubmed publisher

Yamamura Y, Furuichi K, Murakawa Y, Hirabayashi S, Yoshihara M, Sako K, et al. Identification of candidate PAX2-regulated genes implicated in human kidney development. Sci Rep. 2021;11:9123 pubmed publisher

Mancinelli G, Torres C, Krett N, Bauer J, Castellanos K, McKinney R, et al. Role of stromal activin A in human pancreatic cancer and metastasis in mice. Sci Rep. 2021;11:7986 pubmed publisher

Io S, Kabata M, Iemura Y, Semi K, Morone N, Minagawa A, et al. Capturing human trophoblast development with naive pluripotent stem cells in vitro. Cell Stem Cell. 2021;28:1023-1039.e13 pubmed publisher

Chiara Perego M, Bellitto N, Maylem E, Caloni F, Spicer L. Effects of selected hormones and their combination on progesterone and estradiol production and proliferation of feline granulosa cells cultured in vitro. Theriogenology. 2021;168:1-12 pubmed publisher

Lee C, Cho H, Lee J, Son H, Chai J, Kim H. Adhesion GPCR Latrophilin-2 Specifies Cardiac Lineage Commitment through CDK5, Src, and P38MAPK. Stem Cell Reports. 2021;16:868-882 pubmed publisher

Preisler L, Habib A, Shapira G, Kuznitsov Yanovsky L, Mayshar Y, Carmel Gross I, et al. Heterozygous APC germline mutations impart predisposition to colorectal cancer. Sci Rep. 2021;11:5113 pubmed publisher

Rodrigues Toste de Carvalho A, Liu H, Chen Y, Porotto M, Moscona A, Snoeck H. The in vitro multilineage differentiation and maturation of lung and airway cells from human pluripotent stem cell-derived lung progenitors in 3D. Nat Protoc. 2021;16:1802-1829 pubmed publisher

Kadokawa H, Kotaniguchi M, Kereilwe O, Kitamura S. Reduced gonadotroph stimulation by ethanolamine plasmalogens in old bovine brains. Sci Rep. 2021;11:4757 pubmed publisher

Katagiri N, Hitomi H, Mae S, Kotaka M, Lei L, Yamamoto T, et al. Retinoic acid regulates erythropoietin production cooperatively with hypoxia-inducible factors in human iPSC-derived erythropoietin-producing cells. Sci Rep. 2021;11:3936 pubmed publisher

Mischler A, Karakis V, Mahinthakumar J, Carberry C, San Miguel A, Rager J, et al. Two distinct trophectoderm lineage stem cells from human pluripotent stem cells. J Biol Chem. 2021;296:100386 pubmed publisher

Shah P, Lv W, Rhoades J, Poleshko A, Abbey D, Caporizzo M, et al. Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Cell Stem Cell. 2021;: pubmed publisher

Yan Q, Zhang Y, Fang X, Liu B, Wong T, Gong L, et al. PGC7 promotes tumor oncogenic dedifferentiation through remodeling DNA methylation pattern for key developmental transcription factors. Cell Death Differ. 2021;: pubmed publisher

Wu C, Dicks A, Steward N, Tang R, Katz D, Choi Y, et al. Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis. Nat Commun. 2021;12:362 pubmed publisher

Souidi M, Sleiman Y, Acimovic I, Pribyl J, Charrabi A, Baecker V, et al. Oxygen Is an Ambivalent Factor for the Differentiation of Human Pluripotent Stem Cells in Cardiac 2D Monolayer and 3D Cardiac Spheroids. Int J Mol Sci. 2021;22: pubmed publisher

Harland L, Simon C, Senft A, Costello I, Greder L, Imaz Rosshandler I, et al. The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors. Nat Cell Biol. 2021;23:61-74 pubmed publisher

Fang H, Geng S, Hao M, Chen Q, Liu M, Liu C, et al. Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells. Nat Commun. 2021;12:109 pubmed publisher

Barbeau S, Desprat R, Eymard B, Martinat C, Lemaitre J, Legay C. Generation of a human induced pluripotent stem cell line (iPSC) from peripheral blood mononuclear cells of a patient with a myasthenic syndrome due to mutation in COLQ. Stem Cell Res. 2020;49:102106 pubmed publisher

Uchimura K, Wu H, Yoshimura Y, Humphreys B. Human Pluripotent Stem Cell-Derived Kidney Organoids with Improved Collecting Duct Maturation and Injury Modeling. Cell Rep. 2020;33:108514 pubmed publisher

Zheng Y, Shao Y, Fu J. A microfluidics-based stem cell model of early post-implantation human development. Nat Protoc. 2021;16:309-326 pubmed publisher

Michielin F, Giobbe G, Luni C, Hu Q, Maroni I, Orford M, et al. The Microfluidic Environment Reveals a Hidden Role of Self-Organizing Extracellular Matrix in Hepatic Commitment and Organoid Formation of hiPSCs. Cell Rep. 2020;33:108453 pubmed publisher

Hagg A, Kharoud S, Goodchild G, Goodman C, Chen J, Thomson R, et al. TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass. Front Physiol. 2020;11:560225 pubmed publisher

Jiang L, Liu B, Qi Y, Zhu L, Cui X, Liu Z. Antagonistic effects of activin A and TNF-α on the activation of L929 fibroblast cells via Smad3-independent signaling. Sci Rep. 2020;10:20623 pubmed publisher

Mulholland C, Nishiyama A, Ryan J, Nakamura R, Yiğit M, Glück I, et al. Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals. Nat Commun. 2020;11:5972 pubmed publisher

Samuel R, Majd H, Richter M, Ghazizadeh Z, Zekavat S, Navickas A, et al. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men. Cell Stem Cell. 2020;27:876-889.e12 pubmed publisher

Gartz M, Lin C, Sussman M, Lawlor M, Strande J. Duchenne muscular dystrophy (DMD) cardiomyocyte-secreted exosomes promote the pathogenesis of DMD-associated cardiomyopathy. Dis Model Mech. 2020;13: pubmed publisher

Mandal P, De D, Im D, Um S, Kim K. Exosome-Mediated Differentiation of Mouse Embryonic Fibroblasts and Exocrine Cells into β-Like Cells and the Identification of Key miRNAs for Differentiation. Biomedicines. 2020;8: pubmed publisher

Hwang Y, Suzuki S, Seita Y, Ito J, Sakata Y, Aso H, et al. Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells. Nat Commun. 2020;11:5656 pubmed publisher

Fukushima H, Yoshioka M, Kawatou M, López Dávila V, Takeda M, Kanda Y, et al. Specific induction and long-term maintenance of high purity ventricular cardiomyocytes from human induced pluripotent stem cells. PLoS ONE. 2020;15:e0241287 pubmed publisher

Hwang H, Liu R, Maxwell J, Yang J, Xu C. Machine learning identifies abnormal Ca2+ transients in human induced pluripotent stem cell-derived cardiomyocytes. Sci Rep. 2020;10:16977 pubmed publisher

Crosse E, Gordon Keylock S, Rybtsov S, Binagui Casas A, Felchle H, Nnadi N, et al. Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development. Cell Stem Cell. 2020;27:822-839.e8 pubmed publisher

Kiyokawa Y, Sato M, Noguchi H, Inada E, Iwase Y, Kubota N, et al. Drug-Induced Naïve iPS Cells Exhibit Better Performance than Primed iPS Cells with Respect to the Ability to Differentiate into Pancreatic β-Cell Lineage. J Clin Med. 2020;9: pubmed publisher

Duan F, Guo L, Yang L, Han Y, Thakur A, Nilsson Payant B, et al. Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2. Res Sq. 2020;: pubmed publisher

Arita T, Kondo J, Kaneko Y, Tsutsumi M, Kanemaru M, Matsui M, et al. Novel ex vivo disease model for extramammary Paget's disease using the cancer tissue-originated spheroid method. J Dermatol Sci. 2020;99:185-192 pubmed publisher

Chen M, Maimaitili M, Habekost M, Gill K, Mermet Joret N, Nabavi S, et al. Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells. Stem Cell Res. 2020;48:101945 pubmed publisher

Zhang L, Avery J, Yin A, Singh A, Cliff T, Yin H, et al. Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State. Cell Stem Cell. 2020;27:784-797.e11 pubmed publisher

Mae S, Ryosaka M, Sakamoto S, Matsuse K, Nozaki A, Igami M, et al. Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential. Cell Rep. 2020;32:107963 pubmed publisher

Leite N, Sintov E, Meissner T, Brehm M, Greiner D, Harlan D, et al. Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells. Cell Rep. 2020;32:107894 pubmed publisher

Takahashi K, Akatsu Y, Podyma Inoue K, Matsumoto T, Takahashi H, Yoshimatsu Y, et al. Targeting all transforming growth factor-β isoforms with an Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer. J Biol Chem. 2020;295:12559-12572 pubmed publisher

Khoa L, Tsan Y, Mao F, Kremer D, Sajjakulnukit P, Zhang L, et al. Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation. Cell Stem Cell. 2020;27:441-458.e10 pubmed publisher

Yagi M, Kabata M, Tanaka A, Ukai T, Ohta S, Nakabayashi K, et al. Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development. Nat Commun. 2020;11:3199 pubmed publisher

Yang L, Han Y, Nilsson Payant B, Gupta V, Wang P, Duan X, et al. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell Stem Cell. 2020;27:125-136.e7 pubmed publisher

Blanchard J, Bula M, Davila Velderrain J, Akay L, Zhu L, Frank A, et al. Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes. Nat Med. 2020;26:952-963 pubmed publisher

Wei K, Korsunsky I, Marshall J, Gao A, Watts G, Major T, et al. Notch signalling drives synovial fibroblast identity and arthritis pathology. Nature. 2020;582:259-264 pubmed publisher

Takeishi K, Collin de l Hortet A, Wang Y, Handa K, Guzman Lepe J, Matsubara K, et al. Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells. Cell Rep. 2020;31:107711 pubmed publisher

Yamamoto Y, Ito S, Okuda K, Kimura K. Involvement of activin signal pathway in cyclic apoptosis of the oviductal isthmic epithelium in cows. Theriogenology. 2020;153:143-150 pubmed publisher

Nafria M, Keane P, Ng E, Stanley E, Elefanty A, Bonifer C. Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells. Cell Rep. 2020;31:107691 pubmed publisher

Liang H, Zhang P, Bai H, Huang J, Yang H. TATA box-binding protein-related factor 3 drives the mesendoderm specification of human embryonic stem cells by globally interacting with the TATA box of key mesendodermal genes. Stem Cell Res Ther. 2020;11:196 pubmed publisher

Loo L, Soetedjo A, Lau H, Ng N, Ghosh S, Nguyen L, et al. BCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells. Cell Death Dis. 2020;11:378 pubmed publisher

Kumar Gupta A, Sarkar P, Wertheim J, Pan X, Carroll T, Oxburgh L. Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids. Commun Biol. 2020;3:231 pubmed publisher

Fleischer A, Vallejo Díez S, Martín Fernández J, Sanchez Gilabert A, Castresana M, Del Pozo Á, et al. iPSC-Derived Intestinal Organoids from Cystic Fibrosis Patients Acquire CFTR Activity upon TALEN-Mediated Repair of the p.F508del Mutation. Mol Ther Methods Clin Dev. 2020;17:858-870 pubmed publisher

Thomas A, Castellanos K, Mancinelli G, Xia Y, Bauer J, Yazici C, et al. Activin A Modulates Inflammation in Acute Pancreatitis and Strongly Predicts Severe Disease Independent of Body Mass Index. Clin Transl Gastroenterol. 2020;11:e00152 pubmed publisher

Vinckier N, Patel N, Geusz R, Wang A, Wang J, Matta I, et al. LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. Nat Commun. 2020;11:2082 pubmed publisher

Grosch M, Ittermann S, Rusha E, Greisle T, Ori C, Truong D, et al. Nucleus size and DNA accessibility are linked to the regulation of paraspeckle formation in cellular differentiation. BMC Biol. 2020;18:42 pubmed publisher

Tsujimoto H, Kasahara T, Sueta S, Araoka T, Sakamoto S, Okada C, et al. A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells. Cell Rep. 2020;31:107476 pubmed publisher

Yoshida S, Miwa H, Kawachi T, Kume S, Takahashi K. Generation of intestinal organoids derived from human pluripotent stem cells for drug testing. Sci Rep. 2020;10:5989 pubmed publisher

Jeyarajah M, Jaju Bhattad G, Hillier D, Renaud S. The Transcription Factor OVOL2 Represses ID2 and Drives Differentiation of Trophoblast Stem Cells and Placental Development in Mice. Cells. 2020;9: pubmed publisher

Tay W, Fang Y, Beh S, Liu Y, Hsu L, Yen C, et al. Programmed Cell Death-1: Programmed Cell Death-Ligand 1 Interaction Protects Human Cardiomyocytes Against T-Cell Mediated Inflammation and Apoptosis Response In Vitro. Int J Mol Sci. 2020;21: pubmed publisher

Atlasi Y, Jafarnejad S, Gkogkas C, Vermeulen M, Sonenberg N, Stunnenberg H. The translational landscape of ground state pluripotency. Nat Commun. 2020;11:1617 pubmed publisher

Plaza Reyes A, Petrus Reurer S, Padrell Sánchez S, Kumar P, Douagi I, Bartuma H, et al. Identification of cell surface markers and establishment of monolayer differentiation to retinal pigment epithelial cells. Nat Commun. 2020;11:1609 pubmed publisher

Tsukamoto Y, Akagi T, Akashi M. Vascularized cardiac tissue construction with orientation by layer-by-layer method and 3D printer. Sci Rep. 2020;10:5484 pubmed publisher

Cangkrama M, Wietecha M, Mathis N, Okumura R, Ferrarese L, Al Nuaimi D, et al. A paracrine activin A-mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming. EMBO Mol Med. 2020;12:e11466 pubmed publisher

Chanthra N, Abe T, Miyamoto M, Sekiguchi K, Kwon C, Hanazono Y, et al. A Novel Fluorescent Reporter System Identifies Laminin-511/521 as Potent Regulators of Cardiomyocyte Maturation. Sci Rep. 2020;10:4249 pubmed publisher

Liu M, Yan Q, Sun Y, Nam Y, Hu L, Loong J, et al. A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets. Proc Natl Acad Sci U S A. 2020;117:6103-6113 pubmed publisher

Toba Y, Deguchi S, Mimura N, Sakamoto A, Harada K, Hirata K, et al. Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance. PLoS ONE. 2020;15:e0229654 pubmed publisher

Hogrebe N, Augsornworawat P, Maxwell K, Velazco Cruz L, Millman J. Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells. Nat Biotechnol. 2020;38:460-470 pubmed publisher

Gleeson J, Estrada H, Yamashita M, Svendsen C, Targan S, Barrett R. Development of Physiologically Responsive Human iPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD. Int J Mol Sci. 2020;21: pubmed publisher

Kim J, Hwang S, Ryu J, Hong H, Lee J, Lee S, et al. ER stress reliever enhances functionalities of in vitro cultured hepatocytes. Stem Cell Res. 2020;43:101732 pubmed publisher

Yuan Y, Li L, Cheng Q, Diao F, Zeng Q, Yang X, et al. In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids. Cell Res. 2020;30:244-255 pubmed publisher

Wang Y, Lifshitz L, Gellatly K, Vinton C, Busman Sahay K, McCauley S, et al. HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells. Nat Immunol. 2020;21:274-286 pubmed publisher

Buljubasic F, El Battrawy I, Lan H, Lomada S, Chatterjee A, Zhao Z, et al. Nucleoside Diphosphate Kinase B Contributes to Arrhythmogenesis in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes from a Patient with Arrhythmogenic Right Ventricular Cardiomyopathy. J Clin Med. 2020;9: pubmed publisher

Hu J, Liang H, Zhang H, Yang M, Sun W, Zhang P, et al. FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells. Nucleic Acids Res. 2020;48:2733-2748 pubmed publisher

Horvath A, Christ T, Koivumäki J, Prondzynski M, Zech A, Spohn M, et al. Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes-An Artifact by Big Conductance Calcium Activated Potassium Current (Ibk,Ca). Cells. 2020;9: pubmed publisher

Weyers J, Gunaje J, Van Biber B, Martinson A, Reinecke H, Mahoney W, et al. Sonic Hedgehog upregulation does not enhance the survival and engraftment of stem cell-derived cardiomyocytes in infarcted hearts. PLoS ONE. 2020;15:e0227780 pubmed publisher

Bauer J, Emon M, Staudacher J, Thomas A, Zessner Spitzenberg J, Mancinelli G, et al. Increased stiffness of the tumor microenvironment in colon cancer stimulates cancer associated fibroblast-mediated prometastatic activin A signaling. Sci Rep. 2020;10:50 pubmed publisher

Motazedian A, Bruveris F, Kumar S, Schiesser J, Chen T, Ng E, et al. Multipotent RAG1+ progenitors emerge directly from haemogenic endothelium in human pluripotent stem cell-derived haematopoietic organoids. Nat Cell Biol. 2020;22:60-73 pubmed publisher

Shinohara M, Choi H, Ibuki M, Yabe S, Okochi H, Miyajima A, et al. Endodermal differentiation of human induced pluripotent stem cells using simple dialysis culture system in suspension culture. Regen Ther. 2019;12:14-19 pubmed publisher

Matsuura K, Wada M, Sakaguchi K, Matsuhashi Y, Shimizu T. Adequate taylor couette flow-mediated shear stress is useful for dissociating human iPS cell-derived cell aggregates. Regen Ther. 2019;12:6-13 pubmed publisher

Kawai K, Negoro R, Ichikawa M, Yamashita T, Deguchi S, Harada K, et al. Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies. Mol Ther Methods Clin Dev. 2020;17:49-57 pubmed publisher

Loo L, Vethe H, Soetedjo A, Paulo J, Jasmen J, Jackson N, et al. Dynamic proteome profiling of human pluripotent stem cell-derived pancreatic progenitors. Stem Cells. 2020;38:542-555 pubmed publisher

Hiepen C, Jatzlau J, Hildebrandt S, Kampfrath B, Goktas M, Murgai A, et al. BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics. PLoS Biol. 2019;17:e3000557 pubmed publisher

Pan T, Chen Y, Zhuang Y, Yang F, Xu Y, Tao J, et al. Synergistic modulation of signaling pathways to expand and maintain the bipotency of human hepatoblasts. Stem Cell Res Ther. 2019;10:364 pubmed publisher

Chen M, Maimaitili M, Buchholdt S, Jensen U, Febbraro F, Denham M. Generation of eight human induced pluripotent stem cell lines from Parkinson's disease patients carrying familial mutations. Stem Cell Res. 2019;42:101657 pubmed publisher

Subramanian A, Sidhom E, Emani M, Vernon K, Sahakian N, Zhou Y, et al. Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation. Nat Commun. 2019;10:5462 pubmed publisher

Liang W, Han P, Kim E, Mak J, Zhang R, Torrente A, et al. Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells. Stem Cells. 2020;38:352-368 pubmed publisher

Ge J, Sun H, Li J, Shan Y, Zhao Y, Liao F, et al. Involvement of CHOP in activin A‑induced myeloma NS‑1 cell apoptosis. Oncol Rep. 2019;42:2644-2654 pubmed publisher

Guerriero I, De Angelis M, D Angelo F, Leveque R, Savignano E, Roberto L, et al. Exploring the Molecular Crosstalk between Pancreatic Bud and Mesenchyme in Embryogenesis: Novel Signals Involved. Int J Mol Sci. 2019;20: pubmed publisher

Yung T, Poon F, Liang M, Coquenlorge S, McGaugh E, Hui C, et al. Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals. Nat Commun. 2019;10:4647 pubmed publisher

Song W, Chiu A, Wang L, Schwartz R, Li B, Bouklas N, et al. Engineering transferrable microvascular meshes for subcutaneous islet transplantation. Nat Commun. 2019;10:4602 pubmed publisher

Luo M, Bai J, Liu B, Yan P, Zuo F, Sun H, et al. H3K18ac Primes Mesendodermal Differentiation upon Nodal Signaling. Stem Cell Reports. 2019;13:642-656 pubmed publisher

Zamudio A, Dall Agnese A, Henninger J, Manteiga J, Afeyan L, Hannett N, et al. Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes. Mol Cell. 2019;76:753-766.e6 pubmed publisher

Mei Q, Bansal A, Jayakumar M, Zhang Z, Zhang J, Huang H, et al. Manipulating energy migration within single lanthanide activator for switchable upconversion emissions towards bidirectional photoactivation. Nat Commun. 2019;10:4416 pubmed publisher

Gentsch G, Spruce T, Owens N, Smith J. Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals. Nat Commun. 2019;10:4269 pubmed publisher

Zheng Y, Xue X, Shao Y, Wang S, Esfahani S, Li Z, et al. Controlled modelling of human epiblast and amnion development using stem cells. Nature. 2019;573:421-425 pubmed publisher

Song C, Xu F, Ren Z, Zhang Y, Meng Y, Yang Y, et al. Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells. Stem Cell Reports. 2019;13:338-351 pubmed publisher

Cernilogar F, Hasenöder S, Wang Z, Scheibner K, Burtscher I, Sterr M, et al. Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2. Nucleic Acids Res. 2019;47:9069-9086 pubmed publisher

Bai H, Zhang P, Ma L, Liang H, Wei G, Yang H. SMYD2 Drives Mesendodermal Differentiation of Human Embryonic Stem Cells Through Mediating the Transcriptional Activation of Key Mesendodermal Genes. Stem Cells. 2019;: pubmed publisher

Pecha S, Yorgan K, Röhl M, Geertz B, Hansen A, Weinberger F, et al. Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model. Sci Rep. 2019;9:9831 pubmed publisher

Jung K, Kwon O, Lee M, Lee H, Son Y, Habib O, et al. Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells. J Clin Med. 2019;8: pubmed publisher

Choi K, Lee D, Kim S, Woo S, Kim D, Lee C. Chemically Defined Media Can Maintain Pig Pluripotency Network In Vitro. Stem Cell Reports. 2019;13:221-234 pubmed publisher

Takayama K, Negoro R, Yamashita T, Kawai K, Ichikawa M, Mori T, et al. Generation of human iPS cell-derived intestinal epithelial cell monolayers by CDX2 transduction. Cell Mol Gastroenterol Hepatol. 2019;: pubmed publisher

Prajapati DiNubila M, Benito Gonzalez A, Golden E, Zhang S, Doetzlhofer A. A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea. elife. 2019;8: pubmed publisher

Shcherbina A, Li J, Narayanan C, Greenleaf W, Kundaje A, Chetty S. Brief Report: Cell Cycle Dynamics of Human Pluripotent Stem Cells Primed for Differentiation. Stem Cells. 2019;37:1151-1157 pubmed publisher

Jin Q, Qiao C, Li J, Xiao B, Li J, Xiao X. A GDF11/myostatin inhibitor, GDF11 propeptide-Fc, increases skeletal muscle mass and improves muscle strength in dystrophic mdx mice. Skelet Muscle. 2019;9:16 pubmed publisher

Sharon N, Vanderhooft J, Straubhaar J, Mueller J, Chawla R, Zhou Q, et al. Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development. Cell Rep. 2019;27:2281-2291.e5 pubmed publisher

Bijland S, Thomson G, Euston M, Michail K, Thümmler K, Mücklisch S, et al. An in vitro model for studying CNS white matter: functional properties and experimental approaches. F1000Res. 2019;8:117 pubmed publisher

Atlasi Y, Megchelenbrink W, Peng T, Habibi E, Joshi O, Wang S, et al. Epigenetic modulation of a hardwired 3D chromatin landscape in two naive states of pluripotency. Nat Cell Biol. 2019;21:568-578 pubmed publisher

Minami T, Ishii T, Yasuchika K, Fukumitsu K, Ogiso S, Miyauchi Y, et al. Novel hybrid three-dimensional artificial liver using human induced pluripotent stem cells and a rat decellularized liver scaffold. Regen Ther. 2019;10:127-133 pubmed publisher

Regier M, Tokar J, Warrick J, Pabon L, Berthier E, Beebe D, et al. User-defined morphogen patterning for directing human cell fate stratification. Sci Rep. 2019;9:6433 pubmed publisher

Kim J, Kim J, Sutikno L, Lee S, Jin D, Hong Y, et al. Identification of the minimum region of flatfish myostatin propeptide (Pep45-65) for myostatin inhibition and its potential to enhance muscle growth and performance in animals. PLoS ONE. 2019;14:e0215298 pubmed publisher

Genga R, Kernfeld E, Parsi K, Parsons T, Ziller M, Maehr R. Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development. Cell Rep. 2019;27:708-718.e10 pubmed publisher

Ito K, Matsuura K, Mihara Y, Sakamoto Y, Hasegawa K, Kokudo N, et al. Delivery of pancreatic digestive enzymes into the gastrointestinal tract by pancreatic exocrine tissue transplant. Sci Rep. 2019;9:5922 pubmed publisher

Mair B, Tomic J, Masud S, Tonge P, Weiss A, Usaj M, et al. Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies. Cell Rep. 2019;27:599-615.e12 pubmed publisher

Rosado Olivieri E, Anderson K, Kenty J, Melton D. YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells. Nat Commun. 2019;10:1464 pubmed publisher

Wang X, Sterr M, Ansarullah -, Burtscher I, Böttcher A, Beckenbauer J, et al. Point mutations in the PDX1 transactivation domain impair human β-cell development and function. Mol Metab. 2019;24:80-97 pubmed publisher

Xu H, Wang B, Ono M, Kagita A, Fujii K, Sasakawa N, et al. Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility. Cell Stem Cell. 2019;: pubmed publisher

Toba Y, Kiso A, Nakamae S, Sakurai F, Takayama K, Mizuguchi H. FGF signal is not required for hepatoblast differentiation of human iPS cells. Sci Rep. 2019;9:3713 pubmed publisher

Colunga T, Hayworth M, Kreß S, Reynolds D, Chen L, Nazor K, et al. Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair. Cell Rep. 2019;26:2566-2579.e10 pubmed publisher

Noguchi H, Miyagi Shiohira C, Nakashima Y, Kinjo T, Kobayashi N, Saitoh I, et al. Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors. Mol Ther Methods Clin Dev. 2019;13:243-252 pubmed publisher

Ito E, Miyagawa S, Takeda M, Kawamura A, Harada A, Iseoka H, et al. Tumorigenicity assay essential for facilitating safety studies of hiPSC-derived cardiomyocytes for clinical application. Sci Rep. 2019;9:1881 pubmed publisher

Rentsch P, Stayte S, Morris G, Vissel B. Time dependent degeneration of the nigrostriatal tract in mice with 6-OHDA lesioned medial forebrain bundle and the effect of activin A on L-Dopa induced dyskinesia. BMC Neurosci. 2019;20:5 pubmed publisher

Matsui S, Ochiai M, Yasuda K, Mae S, Kotaka M, Toyoda T, et al. Differentiation and isolation of iPSC-derived remodeling ductal plate-like cells by use of an AQP1-GFP reporter human iPSC line. Stem Cell Res. 2019;35:101400 pubmed publisher

Chesnokova V, Zonis S, Barrett R, Kameda H, Wawrowsky K, Ben Shlomo A, et al. Excess growth hormone suppresses DNA damage repair in epithelial cells. JCI Insight. 2019;4: pubmed publisher

Yan Y, Bejoy J, Xia J, Griffin K, Guan J, Li Y. Cell population balance of cardiovascular spheroids derived from human induced pluripotent stem cells. Sci Rep. 2019;9:1295 pubmed publisher

Liu L, Leng L, Liu C, Lu C, Yuan Y, Wu L, et al. An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos. Nat Commun. 2019;10:364 pubmed publisher

Miller A, Dye B, Ferrer Torres D, Hill D, Overeem A, Shea L, et al. Generation of lung organoids from human pluripotent stem cells in vitro. Nat Protoc. 2019;14:518-540 pubmed publisher

Montel Hagen A, Seet C, Li S, Chick B, Zhu Y, Chang P, et al. Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 2019;24:376-389.e8 pubmed publisher

Lin T, Chien Y, Lin Y, Wang M, Yarmishyn A, Yang Y, et al. Establishing Liposome-Immobilized Dexamethasone-Releasing PDMS Membrane for the Cultivation of Retinal Pigment Epithelial Cells and Suppression of Neovascularization. Int J Mol Sci. 2019;20: pubmed publisher

Scavuzzo M, Chmielowiec J, Yang D, Wamble K, Chaboub L, Duraine L, et al. Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA. Cell Rep. 2018;25:3811-3827.e7 pubmed publisher

Li J, Narayanan C, Bian J, Sambo D, Brickler T, Zhang W, et al. A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family. PLoS ONE. 2018;13:e0208110 pubmed publisher

Masuda S, Matsuura K, Shimizu T. Preparation of iPS cell-derived CD31+ endothelial cells using three-dimensional suspension culture. Regen Ther. 2018;9:1-9 pubmed publisher

Negoro R, Takayama K, Kawai K, Harada K, Sakurai F, Hirata K, et al. Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies. Stem Cell Reports. 2018;11:1539-1550 pubmed publisher

Azami T, Matsumoto K, Jeon H, Waku T, Muratani M, Niwa H, et al. Klf5 suppresses ERK signaling in mouse pluripotent stem cells. PLoS ONE. 2018;13:e0207321 pubmed publisher

Wu H, Uchimura K, Donnelly E, Kirita Y, Morris S, Humphreys B. Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics. Cell Stem Cell. 2018;23:869-881.e8 pubmed publisher

Jørgensen A, Macdonald J, Nielsen J, Kilcoyne K, Perlman S, Lundvall L, et al. Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis. Cell Rep. 2018;25:1924-1937.e4 pubmed publisher

Tezuka T, Ota A, Karnan S, Matsuura K, Yokoo K, Hosokawa Y, et al. The plant alkaloid conophylline inhibits matrix formation of fibroblasts. J Biol Chem. 2018;293:20214-20226 pubmed publisher

Ida H, Akiyama T, Ishiguro K, Goparaju S, Nakatake Y, Chikazawa Nohtomi N, et al. Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors. Stem Cell Res Ther. 2018;9:277 pubmed publisher

Yoney A, Etoc F, Ruzo A, Carroll T, Metzger J, Martyn I, et al. WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids. elife. 2018;7: pubmed publisher

Huang D, Wang L, Talbot N, Huang C, Pu L, Zhao X, et al. Analyzing bovine OCT4 and NANOG enhancer activity in pluripotent stem cells using fluorescent protein reporters. PLoS ONE. 2018;13:e0203923 pubmed publisher

Zhang Y, Yang Y, Jiang M, Huang S, Zhang W, Al Alam D, et al. 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling. Cell Stem Cell. 2018;23:516-529.e5 pubmed publisher

Skrzypczyk A, Kehr S, Krystel I, Bernhart S, Giri S, Bader A, et al. Noncoding RNA Transcripts during Differentiation of Induced Pluripotent Stem Cells into Hepatocytes. Stem Cells Int. 2018;2018:5692840 pubmed publisher

Bajaj P, Rodrigues A, Steppan C, Engle S, Mathialagan S, Schroeter T. Human Pluripotent Stem Cell-Derived Kidney Model for Nephrotoxicity Studies. Drug Metab Dispos. 2018;46:1703-1711 pubmed publisher

Lin Y, Chien Y, Chuang J, Chang C, Yang Y, Lai Y, et al. Development of a Graphene Oxide-Incorporated Polydimethylsiloxane Membrane with Hexagonal Micropillars. Int J Mol Sci. 2018;19: pubmed publisher

Scavuzzo M, Hill M, Chmielowiec J, Yang D, Teaw J, Sheng K, et al. Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis. Nat Commun. 2018;9:3356 pubmed publisher

Miyagi Shiohira C, Nakashima Y, Kobayashi N, Saitoh I, Watanabe M, Noguchi H. Characterization of induced tissue-specific stem cells from pancreas by a synthetic self-replicative RNA. Sci Rep. 2018;8:12341 pubmed publisher

Spangler A, Su E, Craft A, Cahan P. A single cell transcriptional portrait of embryoid body differentiation and comparison to progenitors of the developing embryo. Stem Cell Res. 2018;31:201-215 pubmed publisher

Yamada S, Kubo Y, Yamazaki D, Sekino Y, Nomura Y, Yoshida S, et al. Tributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells. Sci Rep. 2018;8:12155 pubmed publisher

Di Baldassarre A, D Amico M, Izzicupo P, Gaggi G, Guarnieri S, Mariggio M, et al. Cardiomyocytes Derived from Human CardiopoieticAmniotic Fluids. Sci Rep. 2018;8:12028 pubmed publisher

Xu Z, He X, Shi X, Xia Y, Liu X, Wu H, et al. Analysis of differentially expressed genes among human hair follicle-derived iPSCs, induced hepatocyte-like cells, and primary hepatocytes. Stem Cell Res Ther. 2018;9:211 pubmed publisher

Andersen P, Tampakakis E, Jimenez D, Kannan S, Miyamoto M, Shin H, et al. Precardiac organoids form two heart fields via Bmp/Wnt signaling. Nat Commun. 2018;9:3140 pubmed publisher

Shoji M, Minato H, Ogaki S, Seki M, Suzuki Y, Kume S, et al. Different murine-derived feeder cells alter the definitive endoderm differentiation of human induced pluripotent stem cells. PLoS ONE. 2018;13:e0201239 pubmed publisher

Magro Lopez E, Palmer C, Manso J, Liste I, Zambrano A. Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids. Stem Cell Res Ther. 2018;9:186 pubmed publisher

Koefoed K, Skat Rørdam J, Andersen P, Warzecha C, Pye M, Andersen T, et al. The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development. Sci Rep. 2018;8:9542 pubmed publisher

Workman M, Gleeson J, Troisi E, Estrada H, Kerns S, HINOJOSA C, et al. Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips. Cell Mol Gastroenterol Hepatol. 2018;5:669-677.e2 pubmed publisher

Zambelli F, Mertens J, Dziedzicka D, Sterckx J, Markouli C, Keller A, et al. Random Mutagenesis, Clonal Events, and Embryonic or Somatic Origin Determine the mtDNA Variant Type and Load in Human Pluripotent Stem Cells. Stem Cell Reports. 2018;11:102-114 pubmed publisher

Li J, Xing F, Chen F, He L, So K, Liu Y, et al. Functional 3D Human Liver Bud Assembled from MSC-Derived Multiple Liver Cell Lineages. Cell Transplant. 2019;28:510-521 pubmed publisher

Russell R, Fu Y, Liu Y, Maye P. Inverse agonism of retinoic acid receptors directs epiblast cells into the paraxial mesoderm lineage. Stem Cell Res. 2018;30:85-95 pubmed publisher

Guo X, Xu Y, Wang Z, Wu Y, Chen J, Wang G, et al. A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis. Cell Stem Cell. 2018;22:893-908.e6 pubmed publisher

Yamane M, Ohtsuka S, Matsuura K, Nakamura A, Niwa H. Overlapping functions of Krüppel-like factor family members: targeting multiple transcription factors to maintain the naïve pluripotency of mouse embryonic stem cells. Development. 2018;145: pubmed publisher

Zhou J, Plagge A, Murray P. Functional comparison of distinct Brachyury+ states in a renal differentiation assay. Biol Open. 2018;7: pubmed publisher

Okamoto R, Takayama K, Akita N, Nagamoto Y, Hosokawa D, Iizuka S, et al. Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B. Cell Transplant. 2018;27:299-309 pubmed publisher

Deutsch M, Doppler S, Li X, Lahm H, Santamaria G, Cuda G, et al. Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis. Cardiovasc Res. 2018;114:1098-1114 pubmed publisher

Jin Y, Liu Y, Li Z, Santostefano K, Shi J, Zhang X, et al. Enhanced differentiation of human pluripotent stem cells into cardiomyocytes by bacteria-mediated transcription factors delivery. PLoS ONE. 2018;13:e0194895 pubmed publisher

Tu J, Tian G, Cheung H, Wei W, Lee T. Gas5 is an essential lncRNA regulator for self-renewal and pluripotency of mouse embryonic stem cells and induced pluripotent stem cells. Stem Cell Res Ther. 2018;9:71 pubmed publisher

Yoshida A, Lee J, Tomoyama S, Miwa K, Shirakawa K, Hamanaka S, et al. In vitro platform of allogeneic stem cell-derived cardiomyocyte transplantation for cardiac conduction defects. Europace. 2018;20:1553-1560 pubmed publisher

Galvan L, Francelle L, Gaillard M, de Longprez L, Carrillo de Sauvage M, Liot G, et al. The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin. Brain. 2018;141:1434-1454 pubmed publisher

Sin Y, Ballantyne L, Richmond C, Funk C. Transplantation of Gene-Edited Hepatocyte-like Cells Modestly Improves Survival of Arginase-1-Deficient Mice. Mol Ther Nucleic Acids. 2018;10:122-130 pubmed publisher

Schöbel A, Rösch K, Herker E. Functional innate immunity restricts Hepatitis C Virus infection in induced pluripotent stem cell-derived hepatocytes. Sci Rep. 2018;8:3893 pubmed publisher

Yang X, Wang R, Wang X, Cai G, Qian Y, Feng S, et al. TGFβ signaling hyperactivation-induced tumorigenicity during the derivation of neural progenitors from mouse ESCs. J Mol Cell Biol. 2018;10:216-228 pubmed publisher

Chen M, Laursen S, Habekost M, Knudsen C, Buchholdt S, Huang J, et al. Central and Peripheral Nervous System Progenitors Derived from Human Pluripotent Stem Cells Reveal a Unique Temporal and Cell-Type Specific Expression of PMCAs. Front Cell Dev Biol. 2018;6:5 pubmed publisher

Ostrin E, Little D, Gerner Mauro K, Sumner E, Ríos Corzo R, Ambrosio E, et al. β-Catenin maintains lung epithelial progenitors after lung specification. Development. 2018;145: pubmed publisher

Zhang R, Koido M, Tadokoro T, Ouchi R, Matsuno T, Ueno Y, et al. Human iPSC-Derived Posterior Gut Progenitors Are Expandable and Capable of Forming Gut and Liver Organoids. Stem Cell Reports. 2018;10:780-793 pubmed publisher

Yamashita T, Takayama K, Sakurai F, Mizuguchi H. Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells. Biochem Biophys Res Commun. 2018;496:1269-1275 pubmed publisher

Long C, Li H, Tiburcy M, Rodriguez Caycedo C, Kyrychenko V, Zhou H, et al. Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing. Sci Adv. 2018;4:eaap9004 pubmed publisher

Dillenburg A, Ireland G, Holloway R, Davies C, Evans F, Swire M, et al. Activin receptors regulate the oligodendrocyte lineage in health and disease. Acta Neuropathol. 2018;135:887-906 pubmed publisher

Lees Shepard J, Yamamoto M, Biswas A, Stoessel S, Nicholas S, Cogswell C, et al. Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva. Nat Commun. 2018;9:471 pubmed publisher

Wang X, Sterr M, Burtscher I, Chen S, Hieronimus A, Machicao F, et al. Genome-wide analysis of PDX1 target genes in human pancreatic progenitors. Mol Metab. 2018;9:57-68 pubmed publisher

Li J, Wu X, Zhou Y, Lee M, Guo L, Han W, et al. Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC. Nucleic Acids Res. 2018;46:2883-2900 pubmed publisher

Fagg W, Liu N, Yang M, Cheng K, Chung E, Kim J, et al. Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver. Cell Transplant. 2017;26:1868-1877 pubmed publisher

Yachie Kinoshita A, Onishi K, Ostblom J, Langley M, Pósfai E, Rossant J, et al. Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions. Mol Syst Biol. 2018;14:e7952 pubmed publisher

Tengroth L, Arebro J, Larsson O, Bachert C, Georén S, Cardell L. Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps. Sci Rep. 2018;8:1561 pubmed publisher

Tumelty K, Higginson Scott N, Fan X, Bajaj P, Knowlton K, Shamashkin M, et al. Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein-Gremlin signaling pathways. J Biol Chem. 2018;293:3039-3055 pubmed publisher

Perino M, Yamanaka S, Riordon D, Tarasova Y, Boheler K. Ascorbic acid promotes cardiomyogenesis through SMAD1 signaling in differentiating mouse embryonic stem cells. PLoS ONE. 2017;12:e0188569 pubmed publisher

Kotaka M, Toyoda T, Yasuda K, Kitano Y, Okada C, Ohta A, et al. Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells. Sci Rep. 2017;7:16734 pubmed publisher

Matson J, Dumitru R, Coryell P, Baxley R, Chen W, Twaroski K, et al. Rapid DNA replication origin licensing protects stem cell pluripotency. elife. 2017;6: pubmed publisher

Varghese D, Parween S, Ardah M, Emerald B, Ansari S. Effects of Aminoglycoside Antibiotics on Human Embryonic Stem Cell Viability during Differentiation In Vitro. Stem Cells Int. 2017;2017:2451927 pubmed publisher

Taguchi A, Nishinakamura R. Higher-Order Kidney Organogenesis from Pluripotent Stem Cells. Cell Stem Cell. 2017;21:730-746.e6 pubmed publisher

Bao S, Tang W, Wu B, Kim S, Li J, Li L, et al. Derivation of hypermethylated pluripotent embryonic stem cells with high potency. Cell Res. 2017;: pubmed publisher

Sakamoto K, Kanematsu Yamaki Y, Kamada Y, Oka M, Ohnishi T, Miwa M, et al. Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology. Biochem Biophys Rep. 2017;11:33-39 pubmed publisher

Merienne N, Vachey G, de Longprez L, Meunier C, Zimmer V, Perriard G, et al. The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes. Cell Rep. 2017;20:2980-2991 pubmed publisher

Ito M, Sun S, Fukuhara T, Suzuki R, Tamai M, Yamauchi T, et al. Development of hepatoma-derived, bidirectional oval-like cells as a model to study host interactions with hepatitis C virus during differentiation. Oncotarget. 2017;8:53899-53915 pubmed publisher

He Z, Xia B, Wang Y, Li J, Feng G, Zhang L, et al. Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening. Cell Rep. 2017;20:2227-2237 pubmed publisher

Cogger K, Sinha A, Sarangi F, McGaugh E, Saunders D, Dorrell C, et al. Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors. Nat Commun. 2017;8:331 pubmed publisher

Kooreman N, de Almeida P, Stack J, Nelakanti R, Diecke S, Shao N, et al. Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics. Cell Rep. 2017;20:1978-1990 pubmed publisher

Merfeld Clauss S, Lu H, Wu X, March K, Traktuev D. Hypoxia-induced activin A diminishes endothelial cell vasculogenic activity. J Cell Mol Med. 2018;22:173-184 pubmed publisher

Xing J, Cao Y, Yu Y, Li H, Song Z, Yu H. In Vitro Micropatterned Human Pluripotent Stem Cell Test (µP-hPST) for Morphometric-Based Teratogen Screening. Sci Rep. 2017;7:8491 pubmed publisher

Palpant N, Wang Y, Hadland B, Zaunbrecher R, Redd M, Jones D, et al. Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis. Cell Rep. 2017;20:1597-1608 pubmed publisher

Hosokawa Y, Toyoda T, Fukui K, Baden M, Funato M, Kondo Y, et al. Insulin-producing cells derived from 'induced pluripotent stem cells' of patients with fulminant type 1 diabetes: Vulnerability to cytokine insults and increased expression of apoptosis-related genes. J Diabetes Investig. 2017;: pubmed publisher

Shao Y, Taniguchi K, Townshend R, Miki T, Gumucio D, Fu J. A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nat Commun. 2017;8:208 pubmed publisher

Lee J, Protze S, Laksman Z, Backx P, Keller G. Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations. Cell Stem Cell. 2017;21:179-194.e4 pubmed publisher

Hino K, Horigome K, Nishio M, Komura S, Nagata S, Zhao C, et al. Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva. J Clin Invest. 2017;127:3339-3352 pubmed publisher

Sallon C, Callebaut I, Boulay I, Fontaine J, Logeart Avramoglou D, Henriquet C, et al. Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells. J Biol Chem. 2017;292:15352-15368 pubmed publisher

Staudacher J, Bauer J, Jana A, Tian J, Carroll T, Mancinelli G, et al. Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer. Sci Rep. 2017;7:5569 pubmed publisher

Goh B, Singhal V, Herrera A, Tomlinson R, Kim S, Faugere M, et al. Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass. J Biol Chem. 2017;292:13809-13822 pubmed publisher

Freire A, Waghray A, Soares da Silva F, Resende T, Lee D, Pereira C, et al. Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate. Stem Cell Reports. 2017;9:136-148 pubmed publisher

Crespo M, Vilar E, Tsai S, Chang K, Amin S, Srinivasan T, et al. Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing. Nat Med. 2017;23:878-884 pubmed publisher

Yücel G, Zhao Z, El Battrawy I, Lan H, Lang S, Li X, et al. Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes. Sci Rep. 2017;7:2935 pubmed publisher

Arauchi A, Matsuura K, Shimizu T, Okano T. Functional Thyroid Follicular Cells Differentiation from Human-Induced Pluripotent Stem Cells in Suspension Culture. Front Endocrinol (Lausanne). 2017;8:103 pubmed publisher

Jeziorowska D, Fontaine V, Jouve C, Villard E, Dussaud S, Akbar D, et al. Differential Sarcomere and Electrophysiological Maturation of Human iPSC-Derived Cardiac Myocytes in Monolayer vs. Aggregation-Based Differentiation Protocols. Int J Mol Sci. 2017;18: pubmed publisher

Seachrist D, Sizemore S, Johnson E, Abdul Karim F, Weber Bonk K, Keri R. Follistatin is a metastasis suppressor in a mouse model of HER2-positive breast cancer. Breast Cancer Res. 2017;19:66 pubmed publisher

Sin Y, Price P, Ballantyne L, Funk C. Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency. Sci Rep. 2017;7:2585 pubmed publisher

Gu Q, Wang J, Wang L, Liu Z, Zhu W, Tan Y, et al. Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations. Stem Cell Reports. 2017;9:366-380 pubmed publisher

Breckwoldt K, Letuffe Brenière D, Mannhardt I, Schulze T, Ulmer B, Werner T, et al. Differentiation of cardiomyocytes and generation of human engineered heart tissue. Nat Protoc. 2017;12:1177-1197 pubmed publisher

Bollum L, Huse K, Oksvold M, Bai B, Hilden V, Forfang L, et al. BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5. PLoS ONE. 2017;12:e0177188 pubmed publisher

Sone M, Morone N, Nakamura T, Tanaka A, Okita K, Woltjen K, et al. Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency. Cell Metab. 2017;25:1103-1117.e6 pubmed publisher

Mitani S, Takayama K, Nagamoto Y, Imagawa K, Sakurai F, Tachibana M, et al. Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling. Mol Ther. 2017;25:1420-1433 pubmed publisher

Low K, Wong L, Maldonado M, Manjunath C, Horner C, Perez M, et al. Physico-electrochemical Characterization of Pluripotent Stem Cells during Self-Renewal or Differentiation by a Multi-modal Monitoring System. Stem Cell Reports. 2017;8:1329-1339 pubmed publisher

Heslop J, Kia R, Pridgeon C, Sison Young R, Liloglou T, Elmasry M, et al. Donor-Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells. Stem Cells Transl Med. 2017;6:1321-1331 pubmed publisher

Latres E, Mastaitis J, Fury W, Miloscio L, Trejos J, Pangilinan J, et al. Activin A more prominently regulates muscle mass in primates than does GDF8. Nat Commun. 2017;8:15153 pubmed publisher

Warrier S, Van der Jeught M, Duggal G, Tilleman L, Sutherland E, Taelman J, et al. Direct comparison of distinct naive pluripotent states in human embryonic stem cells. Nat Commun. 2017;8:15055 pubmed publisher

Hirano K, Konagaya S, Turner A, Noda Y, Kitamura S, Kotera H, et al. Closed-channel culture system for efficient and reproducible differentiation of human pluripotent stem cells into islet cells. Biochem Biophys Res Commun. 2017;487:344-350 pubmed publisher

Pashos E, Park Y, Wang X, Raghavan A, Yang W, Abbey D, et al. Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci. Cell Stem Cell. 2017;20:558-570.e10 pubmed publisher

Li Y, Tian S, Lei I, Liu L, Ma P, Wang Z. Transplantation of multipotent Isl1+ cardiac progenitor cells preserves infarcted heart function in mice. Am J Transl Res. 2017;9:1530-1542 pubmed

Montacir H, Freyer N, Knöspel F, Urbaniak T, Dědová T, Berger M, et al. The Cell-Surface N-Glycome of Human Embryonic Stem Cells and Differentiated Hepatic Cells thereof. Chembiochem. 2017;18:1234-1241 pubmed publisher

Sampaziotis F, de Brito M, Geti I, Bertero A, Hannan N, Vallier L. Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells. Nat Protoc. 2017;12:814-827 pubmed publisher

Tousa S, Semitekolou M, Morianos I, Banos A, Trochoutsou A, Brodie T, et al. Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses. Proc Natl Acad Sci U S A. 2017;114:E2891-E2900 pubmed publisher

Yoshitoshi Uebayashi E, Toyoda T, Yasuda K, Kotaka M, Nomoto K, Okita K, et al. Modelling urea-cycle disorder citrullinemia type 1 with disease-specific iPSCs. Biochem Biophys Res Commun. 2017;486:613-619 pubmed publisher

Asai A, Aihara E, Watson C, Mourya R, Mizuochi T, Shivakumar P, et al. Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells. Development. 2017;144:1056-1064 pubmed publisher

Hammers D, Merscham Banda M, Hsiao J, ENGST S, Hartman J, Sweeney H. Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med. 2017;9:531-544 pubmed publisher

Garcia M, Barrio R, Garcia Lavandeira M, Garcia Rendueles A, Escudero A, Diaz Rodriguez E, et al. The syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGFβ and Activin pathways. Sci Rep. 2017;7:42937 pubmed publisher

Zhang X, Cao H, Bai S, Huo W, Ma Y. Differentiation and characterization of rhesus monkey atrial and ventricular cardiomyocytes from induced pluripotent stem cells. Stem Cell Res. 2017;20:21-29 pubmed publisher

Sambi M, Chow T, Whiteley J, Li M, Chua S, Raileanu V, et al. Acellular Mouse Kidney ECM can be Used as a Three-Dimensional Substrate to Test the Differentiation Potential of Embryonic Stem Cell Derived Renal Progenitors. Stem Cell Rev. 2017;13:513-531 pubmed publisher

Ulmer B, Tingler M, Kurz S, Maerker M, Andre P, Mönch D, et al. A novel role of the organizer gene Goosecoid as an inhibitor of Wnt/PCP-mediated convergent extension in Xenopus and mouse. Sci Rep. 2017;7:43010 pubmed publisher

Koike H, Zhang R, Ueno Y, Sekine K, Zheng Y, Takebe T, et al. Nutritional modulation of mouse and human liver bud growth through a branched-chain amino acid metabolism. Development. 2017;144:1018-1024 pubmed publisher

Valenti G, Quinn H, Heynen G, Lan L, Holland J, Vogel R, et al. Cancer Stem Cells Regulate Cancer-Associated Fibroblasts via Activation of Hedgehog Signaling in Mammary Gland Tumors. Cancer Res. 2017;77:2134-2147 pubmed publisher

Cerdá Esteban N, Naumann H, Ruzittu S, Mah N, Pongrac I, Cozzitorto C, et al. Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2. Nat Commun. 2017;8:14127 pubmed publisher

Voges H, Mills R, Elliott D, Parton R, Porrello E, Hudson J. Development of a human cardiac organoid injury model reveals innate regenerative potential. Development. 2017;144:1118-1127 pubmed publisher

Simon C, Downes D, Gosden M, Telenius J, Higgs D, Hughes J, et al. Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo. Development. 2017;144:1249-1260 pubmed publisher

Tiburcy M, Hudson J, Balfanz P, Schlick S, Meyer T, Chang Liao M, et al. Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair. Circulation. 2017;135:1832-1847 pubmed publisher

Saini J, Corneo B, Miller J, Kiehl T, Wang Q, Boles N, et al. Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration. Cell Stem Cell. 2017;20:635-647.e7 pubmed publisher

Stayte S, Rentsch P, Tröscher A, Bamberger M, Li K, Vissel B. Activin A Inhibits MPTP and LPS-Induced Increases in Inflammatory Cell Populations and Loss of Dopamine Neurons in the Mouse Midbrain In Vivo. PLoS ONE. 2017;12:e0167211 pubmed publisher

Choudhury Y, Toh Y, Xing J, Qu Y, Poh J, Li H, et al. Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity. Sci Rep. 2017;7:41238 pubmed publisher

DEAN M, Davis D, Burdette J. Activin A stimulates migration of the fallopian tube epithelium, an origin of high-grade serous ovarian cancer, through non-canonical signaling. Cancer Lett. 2017;391:114-124 pubmed publisher

Jiajie T, Yanzhou Y, Hoi Hung A, Zi Jiang C, Wai Yee C. Conserved miR-10 family represses proliferation and induces apoptosis in ovarian granulosa cells. Sci Rep. 2017;7:41304 pubmed publisher

Kadota S, Pabon L, Reinecke H, Murry C. In Vivo Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Neonatal and Adult Rat Hearts. Stem Cell Reports. 2017;8:278-289 pubmed publisher

Morizane R, Bonventre J. Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells. Nat Protoc. 2017;12:195-207 pubmed publisher

Golestaneh N, Chu Y, Cheng S, Cao H, Poliakov E, Berinstein D. Repressed SIRT1/PGC-1? pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration. J Transl Med. 2016;14:344 pubmed publisher

Li Y, Schang G, Boehm U, Deng C, Graff J, Bernard D. SMAD3 Regulates Follicle-stimulating Hormone Synthesis by Pituitary Gonadotrope Cells in Vivo. J Biol Chem. 2017;292:2301-2314 pubmed publisher

Lee S, Chong J, Min S, Bak S, Kim K. Are Adipose-Derived Stem Cells From Liver Falciform Ligaments Another Possible Source of Mesenchymal Stem Cells?. Cell Transplant. 2017;26:855-866 pubmed publisher

Antsiferova M, Piwko Czuchra A, Cangkrama M, Wietecha M, Sahin D, Birkner K, et al. Activin promotes skin carcinogenesis by attraction and reprogramming of macrophages. EMBO Mol Med. 2017;9:27-45 pubmed publisher

Parisi S, Passaro F, Russo L, Musto A, Navarra A, Romano S, et al. Lin28 is induced in primed embryonic stem cells and regulates let-7-independent events. FASEB J. 2017;31:1046-1058 pubmed publisher

Palpant N, Pabon L, Friedman C, Roberts M, Hadland B, Zaunbrecher R, et al. Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells. Nat Protoc. 2017;12:15-31 pubmed publisher

Wang Q, Zou Y, Nowotschin S, Kim S, Li Q, Soh C, et al. The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells. Cell Stem Cell. 2017;20:70-86 pubmed publisher

Kumar R, Ciprianidis A, Theis S, Steinbeißer H, Kaufmann L. Nemo-like kinase 1 (Nlk1) and paraxial protocadherin (PAPC) cooperatively control Xenopus gastrulation through regulation of Wnt/planar cell polarity (PCP) signaling. Differentiation. 2017;93:27-38 pubmed publisher

Zeltner N, Fattahi F, Dubois N, Saurat N, Lafaille F, Shang L, et al. Capturing the biology of disease severity in a PSC-based model of familial dysautonomia. Nat Med. 2016;22:1421-1427 pubmed publisher

Ma R, Morshed S, Latif R, Davies T. TAZ Induction Directs Differentiation of Thyroid Follicular Cells from Human Embryonic Stem Cells. Thyroid. 2017;27:292-299 pubmed publisher

Xue L, Xu Z, Wang J, Cui Y, Liu H, Liang W, et al. Activin A/Smads signaling pathway negatively regulates Oxygen Glucose Deprivation-induced autophagy via suppression of JNK and p38 MAPK pathways in neuronal PC12 cells. Biochem Biophys Res Commun. 2016;480:355-361 pubmed publisher

VanOudenhove J, Medina R, Ghule P, Lian J, Stein J, Zaidi S, et al. Transient RUNX1 Expression during Early Mesendodermal Differentiation of hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 Signaling. Stem Cell Reports. 2016;7:884-896 pubmed publisher

Saitoh I, Sato M, Soda M, Inada E, Iwase Y, Murakami T, et al. Tissue-Specific Stem Cells Obtained by Reprogramming of Non-Obese Diabetic (NOD) Mouse-Derived Pancreatic Cells Confer Insulin Production in Response to Glucose. PLoS ONE. 2016;11:e0163580 pubmed publisher

Choudhary P, Whiting P. A strategy to ensure safety of stem cell-derived retinal pigment epithelium cells. Stem Cell Res Ther. 2016;7:127 pubmed publisher

Liu Z, Ning G, Xu R, Cao Y, Meng A, Wang Q. Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation. Nat Commun. 2016;7:12603 pubmed publisher

Barruet E, Morales B, Lwin W, White M, Theodoris C, Kim H, et al. The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling. Stem Cell Res Ther. 2016;7:115 pubmed publisher

Shen X, Soibam B, Benham A, Xu X, Chopra M, Peng X, et al. miR-322/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification. Proc Natl Acad Sci U S A. 2016;113:9551-6 pubmed publisher

Khoa L, Azami T, Tsukiyama T, Matsushita J, Tsukiyama Fujii S, Takahashi S, et al. Visualization of the Epiblast and Visceral Endodermal Cells Using Fgf5-P2A-Venus BAC Transgenic Mice and Epiblast Stem Cells. PLoS ONE. 2016;11:e0159246 pubmed publisher

Locci M, Wu J, Arumemi F, Mikulski Z, Dahlberg C, Miller A, et al. Activin A programs the differentiation of human TFH cells. Nat Immunol. 2016;17:976-84 pubmed publisher

Song L, Chen J, Peng G, Tang K, Jing N. Dynamic Heterogeneity of Brachyury in Mouse Epiblast Stem Cells Mediates Distinct Response to Extrinsic Bone Morphogenetic Protein (BMP) Signaling. J Biol Chem. 2016;291:15212-25 pubmed publisher

Chesnokova V, Zonis S, Zhou C, Recouvreux M, Ben Shlomo A, Araki T, et al. Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A. 2016;113:E3250-9 pubmed publisher

Smith D, Glen K, Thomas R. Automated image analysis with the potential for process quality control applications in stem cell maintenance and differentiation. Biotechnol Prog. 2016;32:215-23 pubmed publisher

Morizane R, Lam A, Freedman B, Kishi S, Valerius M, Bonventre J. Nephron organoids derived from human pluripotent stem cells model kidney development and injury. Nat Biotechnol. 2015;33:1193-200 pubmed

Latres E, Pangilinan J, Miloscio L, Bauerlein R, Na E, Potocky T, et al. Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice. Skelet Muscle. 2015;5:34 pubmed publisher

Bufalino A, Cervigne N, de Oliveira C, Fonseca F, Rodrigues P, Macedo C, et al. Low miR-143/miR-145 Cluster Levels Induce Activin A Overexpression in Oral Squamous Cell Carcinomas, Which Contributes to Poor Prognosis. PLoS ONE. 2015;10:e0136599 pubmed publisher

Nagaoka M, Kobayashi M, Kawai C, Mallanna S, Duncan S. Design of a Vitronectin-Based Recombinant Protein as a Defined Substrate for Differentiation of Human Pluripotent Stem Cells into Hepatocyte-Like Cells. PLoS ONE. 2015;10:e0136350 pubmed publisher

Yang W, Liu Y, Slovik K, Wu J, Duncan S, Rader D, et al. Generation of iPSCs as a Pooled Culture Using Magnetic Activated Cell Sorting of Newly Reprogrammed Cells. PLoS ONE. 2015;10:e0134995 pubmed publisher

Ohsawa Y, Takayama K, Nishimatsu S, Okada T, Fujino M, Fukai Y, et al. The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy. PLoS ONE. 2015;10:e0133713 pubmed publisher

Calderon Gierszal E, Prins G. Directed Differentiation of Human Embryonic Stem Cells into Prostate Organoids In Vitro and its Perturbation by Low-Dose Bisphenol A Exposure. PLoS ONE. 2015;10:e0133238 pubmed publisher

Zhu G, Fei T, Li Z, Yan X, Chen Y. Activin Regulates Self-renewal and Differentiation of Trophoblast Stem Cells by Down-regulating the X Chromosome Gene Bcor. J Biol Chem. 2015;290:22019-29 pubmed publisher

Gerbin K, Yang X, Murry C, Coulombe K. Enhanced Electrical Integration of Engineered Human Myocardium via Intramyocardial versus Epicardial Delivery in Infarcted Rat Hearts. PLoS ONE. 2015;10:e0131446 pubmed publisher

Duggal G, Warrier S, Ghimire S, Broekaert D, Van der Jeught M, Lierman S, et al. Alternative Routes to Induce Naïve Pluripotency in Human Embryonic Stem Cells. Stem Cells. 2015;33:2686-98 pubmed publisher

Dhawan S, Tschen S, Zeng C, Guo T, Hebrok M, MATVEYENKO A, et al. DNA methylation directs functional maturation of pancreatic β cells. J Clin Invest. 2015;125:2851-60 pubmed publisher

Wang Z, Niu W, Wang Y, Teng Z, Wen J, Xia G, et al. Follistatin288 Regulates Germ Cell Cyst Breakdown and Primordial Follicle Assembly in the Mouse Ovary. PLoS ONE. 2015;10:e0129643 pubmed publisher

Merfeld Clauss S, Lupov I, Lu H, March K, Traktuev D. Adipose Stromal Cell Contact with Endothelial Cells Results in Loss of Complementary Vasculogenic Activity Mediated by Induction of Activin A. Stem Cells. 2015;33:3039-51 pubmed publisher

Gancarz A, Wang Z, Schroeder G, Damez Werno D, Braunscheidel K, Mueller L, et al. Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity. Nat Neurosci. 2015;18:959-61 pubmed publisher

Sun G, Hu Z, Min Z, Yan X, Guan Z, Su H, et al. Small C-terminal Domain Phosphatase 3 Dephosphorylates the Linker Sites of Receptor-regulated Smads (R-Smads) to Ensure Transforming Growth Factor β (TGFβ)-mediated Germ Layer Induction in Xenopus Embryos. J Biol Chem. 2015;290:17239-49 pubmed publisher

Craft A, Rockel J, Nartiss Y, Kandel R, Alman B, Keller G. Generation of articular chondrocytes from human pluripotent stem cells. Nat Biotechnol. 2015;33:638-45 pubmed publisher

Stayte S, Rentsch P, Li K, Vissel B. Activin A protects midbrain neurons in the 6-hydroxydopamine mouse model of Parkinson's disease. PLoS ONE. 2015;10:e0124325 pubmed publisher

Wilson C, Ottewell P, Coleman R, Holen I. The differential anti-tumour effects of zoledronic acid in breast cancer - evidence for a role of the activin signaling pathway. BMC Cancer. 2015;15:55 pubmed publisher

Majumder A, Syed K, Joseph S, Scambler P, Dutta D. Histone Chaperone HIRA in Regulation of Transcription Factor RUNX1. J Biol Chem. 2015;290:13053-63 pubmed publisher

Iyer D, Gambardella L, Bernard W, Serrano F, Mascetti V, Pedersen R, et al. Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells. Development. 2015;142:1528-41 pubmed publisher

Dye B, Hill D, Ferguson M, Tsai Y, Nagy M, Dyal R, et al. In vitro generation of human pluripotent stem cell derived lung organoids. elife. 2015;4: pubmed publisher

Haile Y, Nakhaei Nejad M, Boakye P, Baker G, Smith P, Murray A, et al. Reprogramming of HUVECs into induced pluripotent stem cells (HiPSCs), generation and characterization of HiPSC-derived neurons and astrocytes. PLoS ONE. 2015;10:e0119617 pubmed publisher

Yoon S, Foley J, Baker J. HEB associates with PRC2 and SMAD2/3 to regulate developmental fates. Nat Commun. 2015;6:6546 pubmed publisher

Pezzolla D, López Beas J, Lachaud C, Domínguez Rodríguez A, Smani T, Hmadcha A, et al. Resveratrol ameliorates the maturation process of β-cell-like cells obtained from an optimized differentiation protocol of human embryonic stem cells. PLoS ONE. 2015;10:e0119904 pubmed publisher

Sugawa F, Araúzo Bravo M, Yoon J, Kim K, Aramaki S, Wu G, et al. Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile. EMBO J. 2015;34:1009-24 pubmed publisher

Kim M, Horst A, Blinka S, Stamm K, Mahnke D, Schuman J, et al. Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis. PLoS ONE. 2015;10:e0118670 pubmed publisher

Tsankov A, Gu H, Akopian V, Ziller M, Donaghey J, Amit I, et al. Transcription factor binding dynamics during human ES cell differentiation. Nature. 2015;518:344-9 pubmed publisher

Czysz K, Minger S, Thomas N. DMSO efficiently down regulates pluripotency genes in human embryonic stem cells during definitive endoderm derivation and increases the proficiency of hepatic differentiation. PLoS ONE. 2015;10:e0117689 pubmed publisher

Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D Souza S, et al. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Nat Protoc. 2015;10:413-25 pubmed publisher

Fowler T, Kamalakar A, Akel N, Kurten R, Suva L, Gaddy D. Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures. J Cell Sci. 2015;128:683-94 pubmed publisher

Krawchuk D, Anani S, Honma Yamanaka N, Polito S, Shafik M, Yamanaka Y. Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo. J Cell Sci. 2015;128:1011-22 pubmed publisher

Tamminen J, Yin M, Rönty M, Sutinen E, Pasternack A, Ritvos O, et al. Overexpression of activin-A and -B in malignant mesothelioma - attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth. Exp Cell Res. 2015;332:102-15 pubmed publisher

Yang J, Wang W, Ooi J, Campos L, Lu L, Liu P. Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells. Stem Cells. 2015;33:1390-404 pubmed publisher

Katano M, Ema M, Nakachi Y, Mizuno Y, Hirasaki M, Suzuki A, et al. Forced expression of Nanog or Esrrb preserves the ESC status in the absence of nucleostemin expression. Stem Cells. 2015;33:1089-101 pubmed publisher

Galvagni F, Lentucci C, Neri F, Dettori D, De Clemente C, Orlandini M, et al. Snai1 promotes ESC exit from the pluripotency by direct repression of self-renewal genes. Stem Cells. 2015;33:742-50 pubmed publisher

Wu J, Fan Y, Tzanakakis E. Increased culture density is linked to decelerated proliferation, prolonged G1 phase, and enhanced propensity for differentiation of self-renewing human pluripotent stem cells. Stem Cells Dev. 2015;24:892-903 pubmed publisher

Gao W, Zhou P, Ma X, Tschudy Seney B, Chen J, Magner N, et al. Ethanol negatively regulates hepatic differentiation of hESC by inhibition of the MAPK/ERK signaling pathway in vitro. PLoS ONE. 2014;9:e112698 pubmed publisher

Shelton M, Metz J, Liu J, Carpenedo R, Demers S, Stanford W, et al. Derivation and expansion of PAX7-positive muscle progenitors from human and mouse embryonic stem cells. Stem Cell Reports. 2014;3:516-29 pubmed publisher

Wile B, Ban K, Yoon Y, Bao G. Molecular beacon-enabled purification of living cells by targeting cell type-specific mRNAs. Nat Protoc. 2014;9:2411-24 pubmed publisher

Noguchi H, Saitoh I, Tsugata T, Kataoka H, Watanabe M, Noguchi Y. Induction of tissue-specific stem cells by reprogramming factors, and tissue-specific selection. Cell Death Differ. 2015;22:145-55 pubmed publisher

Guo T, Marmol P, Moliner A, Björnholm M, Zhang C, Shokat K, et al. Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity. elife. 2014;3:e03245 pubmed publisher

Gouti M, Tsakiridis A, Wymeersch F, Huang Y, Kleinjung J, Wilson V, et al. In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity. PLoS Biol. 2014;12:e1001937 pubmed publisher

Noguchi F, Nakajima T, Inui S, Reddy J, Itami S. Alteration of skin wound healing in keratinocyte-specific mediator complex subunit 1 null mice. PLoS ONE. 2014;9:e102271 pubmed publisher

Onishi K, Tonge P, Nagy A, Zandstra P. Local BMP-SMAD1 signaling increases LIF receptor-dependent STAT3 responsiveness and primed-to-naive mouse pluripotent stem cell conversion frequency. Stem Cell Reports. 2014;3:156-68 pubmed publisher

Hua X, Wang Y, Tang Y, Yu S, Jin S, Meng X, et al. Pancreatic insulin-producing cells differentiated from human embryonic stem cells correct hyperglycemia in SCID/NOD mice, an animal model of diabetes. PLoS ONE. 2014;9:e102198 pubmed publisher

Dambrot C, Braam S, Tertoolen L, Birket M, Atsma D, Mummery C. Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes. J Cell Mol Med. 2014;18:1509-18 pubmed publisher

Zhu Q, Song L, Peng G, Sun N, Chen J, Zhang T, et al. The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways. elife. 2014;3: pubmed publisher

Togashi Y, Sakamoto H, Hayashi H, Terashima M, De Velasco M, Fujita Y, et al. Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer. Mol Cancer. 2014;13:126 pubmed publisher

Pethe P, Nagvenkar P, Bhartiya D. Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro. BMC Cell Biol. 2014;15:18 pubmed publisher

Ferrer M, Corneo B, Davis J, Wan Q, Miyagishima K, King R, et al. A multiplex high-throughput gene expression assay to simultaneously detect disease and functional markers in induced pluripotent stem cell-derived retinal pigment epithelium. Stem Cells Transl Med. 2014;3:911-22 pubmed publisher

Poh Y, Chen J, Hong Y, Yi H, Zhang S, Chen J, et al. Generation of organized germ layers from a single mouse embryonic stem cell. Nat Commun. 2014;5:4000 pubmed publisher

Hinton A, Hunter S, Afrikanova I, Jones G, Lopez A, Fogel G, et al. sRNA-seq analysis of human embryonic stem cells and definitive endoderm reveals differentially expressed microRNAs and novel IsomiRs with distinct targets. Stem Cells. 2014;32:2360-72 pubmed publisher

Fuerer C, Nostro M, Constam D. Nodal·Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation. J Biol Chem. 2014;289:17854-71 pubmed publisher

Jørgensen A, Young J, Nielsen J, Joensen U, Toft B, Rajpert De Meyts E, et al. Hanging drop cultures of human testis and testis cancer samples: a model used to investigate activin treatment effects in a preserved niche. Br J Cancer. 2014;110:2604-14 pubmed publisher

Chong J, Yang X, Don C, Minami E, Liu Y, Weyers J, et al. Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts. Nature. 2014;510:273-7 pubmed publisher

Mitchell R, Szabo E, Shapovalova Z, Aslostovar L, Makondo K, Bhatia M. Molecular evidence for OCT4-induced plasticity in adult human fibroblasts required for direct cell fate conversion to lineage specific progenitors. Stem Cells. 2014;32:2178-87 pubmed publisher

Tsukiyama T, Ohinata Y. A modified EpiSC culture condition containing a GSK3 inhibitor can support germline-competent pluripotency in mice. PLoS ONE. 2014;9:e95329 pubmed publisher

Luo J, Weaver M, Cao B, Dennis J, Van Biber B, Laflamme M, et al. Cobalt protoporphyrin pretreatment protects human embryonic stem cell-derived cardiomyocytes from hypoxia/reoxygenation injury in vitro and increases graft size and vascularization in vivo. Stem Cells Transl Med. 2014;3:734-44 pubmed publisher

Ohnuma K, Fujiki A, Yanagihara K, Tachikawa S, Hayashi Y, Ito Y, et al. Enzyme-free passage of human pluripotent stem cells by controlling divalent cations. Sci Rep. 2014;4:4646 pubmed publisher

Kowno M, Watanabe Susaki K, Ishimine H, Komazaki S, Enomoto K, Seki Y, et al. Prohibitin 2 regulates the proliferation and lineage-specific differentiation of mouse embryonic stem cells in mitochondria. PLoS ONE. 2014;9:e81552 pubmed publisher

Watanabe H, Takayama K, Inamura M, Tachibana M, Mimura N, Katayama K, et al. HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin. PLoS ONE. 2014;9:e90791 pubmed publisher

Carrancio S, Markovics J, Wong P, Leisten J, Castiglioni P, Groza M, et al. An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin. Br J Haematol. 2014;165:870-82 pubmed publisher

Liu Y, Kaneda R, Leja T, Subkhankulova T, Tolmachov O, Minchiotti G, et al. Hhex and Cer1 mediate the Sox17 pathway for cardiac mesoderm formation in embryonic stem cells. Stem Cells. 2014;32:1515-26 pubmed publisher

Eresheim C, Leeb C, Buchegger P, Nimpf J. Signaling by the extracellular matrix protein Reelin promotes granulosa cell proliferation in the chicken follicle. J Biol Chem. 2014;289:10182-91 pubmed publisher

Suresh Babu S, Valdez Y, Xu A, O Byrne A, Calvo F, Lei V, et al. TGF?-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells. BMC Cancer. 2014;14:113 pubmed publisher

Hakim F, Kaitsuka T, Raeed J, Wei F, Shiraki N, Akagi T, et al. High oxygen condition facilitates the differentiation of mouse and human pluripotent stem cells into pancreatic progenitors and insulin-producing cells. J Biol Chem. 2014;289:9623-38 pubmed publisher

Ono T, Suzuki Y, Kato Y, Fujita R, Araki T, Yamashita T, et al. A single-cell and feeder-free culture system for monkey embryonic stem cells. PLoS ONE. 2014;9:e88346 pubmed publisher

Takebe T, Zhang R, Koike H, Kimura M, Yoshizawa E, Enomura M, et al. Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant. Nat Protoc. 2014;9:396-409 pubmed publisher

Araoka T, Mae S, Kurose Y, Uesugi M, Ohta A, Yamanaka S, et al. Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods. PLoS ONE. 2014;9:e84881 pubmed publisher

Seth A, Ye J, Yu N, Guez F, Bedford D, Neale G, et al. Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014;141:538-47 pubmed publisher

Massumi M, Hoveizi E, Baktash P, Hooti A, Ghazizadeh L, Nadri S, et al. Efficient programming of human eye conjunctiva-derived induced pluripotent stem (ECiPS) cells into definitive endoderm-like cells. Exp Cell Res. 2014;322:51-61 pubmed publisher

Singh A, Chappell J, Trost R, Lin L, Wang T, Tang J, et al. Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells. Stem Cell Reports. 2013;1:532-44 pubmed publisher

Lam A, Freedman B, Morizane R, Lerou P, Valerius M, Bonventre J. Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. J Am Soc Nephrol. 2014;25:1211-25 pubmed publisher

Lippmann E, Estevez Silva M, Ashton R. Defined human pluripotent stem cell culture enables highly efficient neuroepithelium derivation without small molecule inhibitors. Stem Cells. 2014;32:1032-42 pubmed publisher

Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, Sasaki H, et al. Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell. 2014;14:53-67 pubmed publisher

Takayama K, Nagamoto Y, Mimura N, Tashiro K, Sakurai F, Tachibana M, et al. Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes. Stem Cell Reports. 2013;1:322-35 pubmed publisher

Fortin J, Boehm U, WEINSTEIN M, Graff J, Bernard D. Follicle-stimulating hormone synthesis and fertility are intact in mice lacking SMAD3 DNA binding activity and SMAD2 in gonadotrope cells. FASEB J. 2014;28:1474-85 pubmed publisher

Kaitsuka T, Noguchi H, Shiraki N, Kubo T, Wei F, Hakim F, et al. Generation of functional insulin-producing cells from mouse embryonic stem cells through 804G cell-derived extracellular matrix and protein transduction of transcription factors. Stem Cells Transl Med. 2014;3:114-27 pubmed publisher

Huang S, Islam M, O NEILL J, Hu Z, Yang Y, Chen Y, et al. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol. 2014;32:84-91 pubmed publisher

Takayama K, Kawabata K, Nagamoto Y, Inamura M, Ohashi K, Okuno H, et al. CCAAT/enhancer binding protein-mediated regulation of TGF? receptor 2 expression determines the hepatoblast fate decision. Development. 2014;141:91-100 pubmed publisher

Garrel G, Simon V, Denoyelle C, Ishaq M, Rouch C, Dairou J, et al. Unsaturated fatty acids disrupt Smad signaling in gonadotrope cells leading to inhibition of FSHβ gene expression. Endocrinology. 2014;155:592-604 pubmed publisher

Turnbull I, Karakikes I, Serrao G, Backeris P, Lee J, Xie C, et al. Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium. FASEB J. 2014;28:644-54 pubmed publisher

Xu D, Nishimura T, Zheng M, Wu M, Su H, Sato N, et al. Enabling autologous human liver regeneration with differentiated adipocyte stem cells. Cell Transplant. 2014;23:1573-84 pubmed publisher

Lin P, Hung S, Yang Y, Liao L, Hsieh Y, Yen H, et al. A synthetic peptide-acrylate surface for production of insulin-producing cells from human embryonic stem cells. Stem Cells Dev. 2014;23:372-9 pubmed publisher

Liang P, Lan F, Sanchez Freire V, Simmons C, Gong T, Sharma A, et al. Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation. 2013;128:S3-13 pubmed publisher

Duggal G, Heindryckx B, Warrier S, O Leary T, Van der Jeught M, Lierman S, et al. Influence of activin A supplementation during human embryonic stem cell derivation on germ cell differentiation potential. Stem Cells Dev. 2013;22:3141-55 pubmed publisher

Goldman O, Han S, Sourisseau M, Sourrisseau M, Dziedzic N, Hamou W, et al. KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development. Cell Stem Cell. 2013;12:748-60 pubmed publisher

Buchholz D, Pennington B, Croze R, Hinman C, Coffey P, Clegg D. Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium. Stem Cells Transl Med. 2013;2:384-93 pubmed publisher

Zhang Q, Sun H, Jiang Y, Ding L, Wu S, Fang T, et al. MicroRNA-181a suppresses mouse granulosa cell proliferation by targeting activin receptor IIA. PLoS ONE. 2013;8:e59667 pubmed publisher

Hoffman J, Wu C, Merrill B. Tcf7l1 prepares epiblast cells in the gastrulating mouse embryo for lineage specification. Development. 2013;140:1665-75 pubmed publisher

Narayanan K, Schumacher K, Tasnim F, Kandasamy K, Schumacher A, Ni M, et al. Human embryonic stem cells differentiate into functional renal proximal tubular-like cells. Kidney Int. 2013;83:593-603 pubmed publisher

Mae S, Shono A, Shiota F, Yasuno T, Kajiwara M, Gotoda Nishimura N, et al. Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells. Nat Commun. 2013;4:1367 pubmed publisher

Brafman D, Phung C, Kumar N, Willert K. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Cell Death Differ. 2013;20:369-81 pubmed publisher

White M, Rufaihah A, Liu L, Ghebremariam Y, Ivey K, Cooke J, et al. Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells. Stem Cells. 2013;31:92-103 pubmed publisher

Sneddon J, Borowiak M, Melton D. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature. 2012;491:765-8 pubmed publisher

Sui L, Mfopou J, Geens M, Sermon K, Bouwens L. FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells. Biochem Biophys Res Commun. 2012;426:380-5 pubmed publisher

Pereira P, Dobreva M, Maas E, Cornelis F, Moya I, Umans L, et al. Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion. Development. 2012;139:3343-54 pubmed publisher

Bruce D, MacArtney T, Yong W, Shou W, Sapkota G. Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-? pathway. Cell Signal. 2012;24:1999-2006 pubmed publisher

Shah S, Lowery E, Braun R, Martin A, Huang N, Medina M, et al. Cellular basis of tissue regeneration by omentum. PLoS ONE. 2012;7:e38368 pubmed publisher

Yu Q, Hirst C, Costa M, Ng E, Schiesser J, Gertow K, et al. APELIN promotes hematopoiesis from human embryonic stem cells. Blood. 2012;119:6243-54 pubmed publisher

Jeon K, Lim H, Kim J, Thuan N, Park S, Lim Y, et al. Differentiation and transplantation of functional pancreatic beta cells generated from induced pluripotent stem cells derived from a type 1 diabetes mouse model. Stem Cells Dev. 2012;21:2642-55 pubmed publisher

Wang P, McKnight K, Wong D, Rodriguez R, Sugiyama T, Gu X, et al. A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells. Stem Cells Dev. 2012;21:2273-87 pubmed publisher

Joubin K, Richardson A, Novoa N, Tu E, Tomishima M. The endothelial cell line bEnd.3 maintains human pluripotent stem cells. Stem Cells Dev. 2012;21:2312-21 pubmed publisher

Prabakar K, Dominguez Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, et al. Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells. Cell Transplant. 2012;21:1321-39 pubmed publisher

Mottershead D, Ritter L, Gilchrist R. Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15. Mol Hum Reprod. 2012;18:121-8 pubmed publisher

Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher

Tsai S, Bouwman B, Ang Y, Kim S, Lee D, Lemischka I, et al. Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells. Stem Cells. 2011;29:964-71 pubmed publisher

Spence J, Mayhew C, Rankin S, Kuhar M, Vallance J, Tolle K, et al. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature. 2011;470:105-9 pubmed publisher

Zhang Q, Jiang J, Han P, Yuan Q, Zhang J, Zhang X, et al. Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals. Cell Res. 2011;21:579-87 pubmed publisher

Klim J, Li L, Wrighton P, Piekarczyk M, Kiessling L. A defined glycosaminoglycan-binding substratum for human pluripotent stem cells. Nat Methods. 2010;7:989-94 pubmed publisher

Emre N, Vidal J, Elia J, O Connor E, Paramban R, Hefferan M, et al. The ROCK inhibitor Y-27632 improves recovery of human embryonic stem cells after fluorescence-activated cell sorting with multiple cell surface markers. PLoS ONE. 2010;5:e12148 pubmed publisher

Roelandt P, Pauwelyn K, Sancho Bru P, Subramanian K, Bose B, Ordovas L, et al. Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS ONE. 2010;5:e12101 pubmed publisher

Tramullas M, Lantero A, Diaz A, Morchón N, Merino D, Villar A, et al. BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) reveals the involvement of the transforming growth factor-beta family in pain modulation. J Neurosci. 2010;30:1502-11 pubmed publisher

Chng Z, Teo A, Pedersen R, Vallier L. SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells. Cell Stem Cell. 2010;6:59-70 pubmed publisher

Chayosumrit M, Tuch B, Sidhu K. Alginate microcapsule for propagation and directed differentiation of hESCs to definitive endoderm. Biomaterials. 2010;31:505-14 pubmed publisher

Hansson M, Olesen D, Peterslund J, Engberg N, Kahn M, Winzi M, et al. A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. Dev Biol. 2009;330:286-304 pubmed publisher

Borowiak M, Maehr R, Chen S, Chen A, Tang W, Fox J, et al. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell. 2009;4:348-58 pubmed publisher

Dickinson R, Stewart A, Myers M, Millar R, Duncan W. Differential expression and functional characterization of luteinizing hormone receptor splice variants in human luteal cells: implications for luteolysis. Endocrinology. 2009;150:2873-81 pubmed publisher

Stevens K, Pabon L, Muskheli V, Murry C. Scaffold-free human cardiac tissue patch created from embryonic stem cells. Tissue Eng Part A. 2009;15:1211-22 pubmed publisher

Bernardo A, Cho C, Mason S, Docherty H, Pedersen R, Vallier L, et al. Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells. Stem Cells. 2009;27:341-51 pubmed publisher

Jeanpierre S, Nicolini F, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, et al. BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling. Blood. 2008;112:3154-63 pubmed publisher

Wu Z, Zhang W, Chen G, Cheng L, Liao J, Jia N, et al. Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells. J Biol Chem. 2008;283:24991-5002 pubmed publisher

Desbordes S, Placantonakis D, Ciro A, Socci N, Lee G, Djaballah H, et al. High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell. 2008;2:602-12 pubmed publisher

Yang L, Soonpaa M, Adler E, Roepke T, Kattman S, Kennedy M, et al. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature. 2008;453:524-8 pubmed publisher

Shiraki N, Yoshida T, Araki K, Umezawa A, Higuchi Y, Goto H, et al. Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm. Stem Cells. 2008;26:874-85 pubmed publisher

Schulz T, Swistowska A, Liu Y, Swistowski A, Palmarini G, Brimble S, et al. A large-scale proteomic analysis of human embryonic stem cells. BMC Genomics. 2007;8:478 pubmed

Cho Y, Lim J, Yoo D, Kim J, Chung S, Park S, et al. Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells. Biochem Biophys Res Commun. 2008;366:129-34 pubmed

Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861-72 pubmed

Alexander S, Watt F, Sawaji Y, Hermansson M, Saklatvala J. Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB. Arthritis Rheum. 2007;56:3715-25 pubmed

Tahinci E, Thorne C, Franklin J, Salic A, Christian K, Lee L, et al. Lrp6 is required for convergent extension during Xenopus gastrulation. Development. 2007;134:4095-106 pubmed

Oki S, Hashimoto R, Okui Y, Shen M, Mekada E, Otani H, et al. Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo. Development. 2007;134:3893-904 pubmed

Kavanagh K, Evans A, Jernvall J. Predicting evolutionary patterns of mammalian teeth from development. Nature. 2007;449:427-32 pubmed

Wang L, Schulz T, Sherrer E, Dauphin D, Shin S, Nelson A, et al. Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling. Blood. 2007;110:4111-9 pubmed

Kupershmidt L, Amit T, Bar Am O, Youdim M, Blumenfeld Z. The neuroprotective effect of Activin A and B: implication for neurodegenerative diseases. J Neurochem. 2007;103:962-71 pubmed

Tesar P, Chenoweth J, Brook F, Davies T, Evans E, Mack D, et al. New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature. 2007;448:196-9 pubmed

Tamura K, Matsushita M, Endo A, Kutsukake M, Kogo H. Effect of insulin-like growth factor-binding protein 7 on steroidogenesis in granulosa cells derived from equine chorionic gonadotropin-primed immature rat ovaries. Biol Reprod. 2007;77:485-91 pubmed

Ilancheran S, Michalska A, Peh G, Wallace E, Pera M, Manuelpillai U. Stem cells derived from human fetal membranes display multilineage differentiation potential. Biol Reprod. 2007;77:577-88 pubmed

Eijken M, Swagemakers S, Koedam M, Steenbergen C, Derkx P, Uitterlinden A, et al. The activin A-follistatin system: potent regulator of human extracellular matrix mineralization. FASEB J. 2007;21:2949-60 pubmed

Sherwood R, Jitianu C, Cleaver O, Shaywitz D, Lamenzo J, Chen A, et al. Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Dev Biol. 2007;304:541-55 pubmed

Vallier L, Alexander M, Pedersen R. Conditional gene expression in human embryonic stem cells. Stem Cells. 2007;25:1490-7 pubmed

McLean A, D Amour K, Jones K, Krishnamoorthy M, Kulik M, Reynolds D, et al. Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells. 2007;25:29-38 pubmed

Greber B, Lehrach H, Adjaye J. Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal. Stem Cells. 2007;25:455-64 pubmed

Mukhopadhyay A, Chan S, Lim I, Phillips D, Phan T. The role of the activin system in keloid pathogenesis. Am J Physiol Cell Physiol. 2007;292:C1331-8 pubmed

Kurita R, Sasaki E, Yokoo T, Hiroyama T, Takasugi K, Imoto H, et al. Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells. Stem Cells. 2006;24:2014-22 pubmed

Maeshima A, Vaughn D, Choi Y, Nigam S. Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev Biol. 2006;295:473-85 pubmed

Yao S, Chen S, Clark J, Hao E, Beattie G, Hayek A, et al. Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proc Natl Acad Sci U S A. 2006;103:6907-12 pubmed

Silva J, Tharasanit T, Taverne M, van der Weijden G, Santos R, Figueiredo J, et al. The activin-follistatin system and in vitro early follicle development in goats. J Endocrinol. 2006;189:113-25 pubmed

Ng R, Gurdon J. Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer. Proc Natl Acad Sci U S A. 2005;102:1957-62 pubmed

Tardif G, Hum D, Pelletier J, Boileau C, Ranger P, Martel Pelletier J. Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts. Arthritis Rheum. 2004;50:2521-30 pubmed

Gilchrist R, Ritter L, Cranfield M, Jeffery L, Amato F, Scott S, et al. Immunoneutralization of growth differentiation factor 9 reveals it partially accounts for mouse oocyte mitogenic activity. Biol Reprod. 2004;71:732-9 pubmed

Oren A, Toporik A, Biton S, Almogy N, Eshel D, Bernstein J, et al. hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. Gene. 2004;331:17-31 pubmed

Grimm O, Gurdon J. Nuclear exclusion of Smad2 is a mechanism leading to loss of competence. Nat Cell Biol. 2002;4:519-22 pubmed

Kawakami S, Fujii Y, Okada Y, Winters S. Paracrine regulation of FSH by follistatin in folliculostellate cell-enriched primate pituitary cell cultures. Endocrinology. 2002;143:2250-8 pubmed