Recombinant Mouse CD200 Fc Chimera Protein, CF | R&D Systems 3355-CD-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse CD200 Fc Chimera Protein, CF

catalog :

3355-CD-050

quantity :

50 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Chen X, Cui Q, Hu X, Ye J, Liu Z, Mei Y, et al. CD200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation. J Neuroinflammation. 2023;20:157 pubmed publisher
Chamera K, Curzytek K, Kami x144 ska K, Trojan E, Le x15b kiewicz M, Tylek K, et al. Insights into the Potential Impact of Quetiapine on the Microglial Trajectory and Inflammatory Response in Organotypic Cortical Cultures Derived from Rat Offspring. Biomedicines. 2023;11: pubmed publisher
Shafiei Jahani P, Helou D, Hurrell B, Howard E, Quach C, Painter J, et al. CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma. Nat Commun. 2021;12:2526 pubmed publisher
Casulli J, Fife M, Houston S, Rossi S, Dow J, Williamson E, et al. CD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality. Nat Commun. 2019;10:2121 pubmed publisher
Zhu B, Yu Y, Liu X, Han Q, Kang Y, Shi L. CD200 Modulates S. aureus-Induced Innate Immune Responses Through Suppressing p38 Signaling. Int J Mol Sci. 2019;20: pubmed publisher
HernangÃ³mez M, KlusÃ¡kovÃ¡ I, Joukal M, HradilovÃ¡ SvÃÅ¾enskÃ¡ I, Guaza C, DubovÃ½ P. CD200R1 agonist attenuates glial activation, inflammatory reactions, and hypersensitivity immediately after its intrathecal application in a rat neuropathic pain model. J Neuroinflammation. 2016;13:43 pubmed publisher
Lyons A, Downer E, Costello D, Murphy N, Lynch M. Dok2 mediates the CD200Fc attenuation of A?-induced changes in glia. J Neuroinflammation. 2012;9:107 pubmed publisher
Guarda G, Dostert C, Staehli F, Cabalzar K, Castillo R, Tardivel A, et al. T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature. 2009;460:269-73 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

3355-CD

SKU :

3355-CD-050

product name :

Recombinant Mouse CD200 Fc Chimera Protein, CF

Description :

The Recombinant Mouse CD200 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse CD200 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

CD200

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Mouse

observed molecular weight :

65-75 kDa, reducing conditions

theoretical molecular weight :

49 kDa (monomer)

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Mouse CD200 R1 Fc Chimera (Catalog # 2554-CD ) is immobilized at 2 µg/mL (100 µL/well), the concentration of Recombinant Mouse CD200 Fc Chimera that produces 50% of the optimal binding response is appoximately 5-30 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

O54901

applications :

Binding Activity

source :

NS0-derived Recombinant Mouse CD200 Fc Chimera Protein

USD :

423 USD

alt names :

antigen identified by monoclonal MRC OX-2, CD200, CD200 antigenMOX1, CD200 molecule, MOX1, MOX2, MOX2MRC, MRC, MRC OX-2 antigen, OX-2, OX-2 membrane glycoprotein

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage