This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Noggin Fc Chimera Protein, CF
catalog :
3344-NG
quantity :
50 ug (also 100 ug, 500 ug)
price :
329 USD
citations: 17
Reference
Chung S, Shen W, Davidson K, Pebay A, Wong R, Yau B, et al. Differentiation of Retinal Glial Cells From Human Embryonic Stem Cells by Promoting the Notch Signaling Pathway. Front Cell Neurosci. 2019;13:527 pubmed publisher
Matjusaitis M, Wagstaff L, Martella A, Baranowski B, Blin C, Gogolok S, et al. Reprogramming of Fibroblasts to Oligodendrocyte Progenitor-like Cells Using CRISPR/Cas9-Based Synthetic Transcription Factors. Stem Cell Reports. 2019;13:1053-1067 pubmed publisher
Scerbo P, Marchal L, Kodjabachian L. Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2. elife. 2017;6: pubmed publisher
Kestens C, Siersema P, Offerhaus G, van Baal J. BMP4 Signaling Is Able to Induce an Epithelial-Mesenchymal Transition-Like Phenotype in Barrett's Esophagus and Esophageal Adenocarcinoma through Induction of SNAIL2. PLoS ONE. 2016;11:e0155754 pubmed publisher
Guezguez A, Paré F, Benoit Y, Basora N, Beaulieu J. Modulation of stemness in a human normal intestinal epithelial crypt cell line by activation of the WNT signaling pathway. Exp Cell Res. 2014;322:355-64 pubmed publisher
Shi Y, Kirwan P, Livesey F. Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks. Nat Protoc. 2012;7:1836-46 pubmed publisher
Prabakar K, Dominguez Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, et al. Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells. Cell Transplant. 2012;21:1321-39 pubmed publisher
Kelly O, Chan M, Martinson L, Kadoya K, Ostertag T, Ross K, et al. Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells. Nat Biotechnol. 2011;29:750-6 pubmed publisher
Kelly M, Hirschi K. Signaling hierarchy regulating human endothelial cell development. Arterioscler Thromb Vasc Biol. 2009;29:718-24 pubmed publisher
Gil J, Woo D, Shim J, Kim S, You H, Park S, et al. Vitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cells. FEBS Lett. 2009;583:561-7 pubmed publisher
Yao Y, Shao E, Jumabay M, Shahbazian A, Ji S, BOSTROM K. High-density lipoproteins affect endothelial BMP-signaling by modulating expression of the activin-like kinase receptor 1 and 2. Arterioscler Thromb Vasc Biol. 2008;28:2266-74 pubmed publisher
Elkabetz Y, Panagiotakos G, Al Shamy G, Socci N, Tabar V, Studer L. Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev. 2008;22:152-65 pubmed publisher
Wen Z, Han L, Bamburg J, Shim S, Ming G, Zheng J. BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin. J Cell Biol. 2007;178:107-19 pubmed publisher
Knobloch J, Shaughnessy J, Ruther U. Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway. FASEB J. 2007;21:1410-21 pubmed
McLean A, D Amour K, Jones K, Krishnamoorthy M, Kulik M, Reynolds D, et al. Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells. 2007;25:29-38 pubmed
Bonafede A, Kohler T, Rodriguez Niedenführ M, Brand Saberi B. BMPs restrict the position of premuscle masses in the limb buds by influencing Tcf4 expression. Dev Biol. 2006;299:330-44 pubmed
Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, et al. Multipotent adult progenitor cells from swine bone marrow. Stem Cells. 2006;24:2355-66 pubmed
product information
brand :
R&D Systems
master code :
3344-NG
SKU :
3344-NG-050
product name :
Recombinant Human Noggin Fc Chimera Protein, CF
description :
The Recombinant Human Noggin Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Noggin Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
Noggin
category :
Proteins and Enzymes
unit size :
50 ug (also 100 ug, 500 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
58-62 kDa, reducing conditions
theoretical molecular weight :
49.6 kDa (monomer)
gene symbol :
NOG
details of functionality :
Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.1-0.4 µg/mL in the presence of 30 ng/mL of Recombinant Human BMP-4 (Catalog # 314-BP ).
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
catalog number base :
3344-NG
accessionNumbers :
Q13253
applications :
Bioactivity
source :
Mouse myeloma cell line, NS0-derived human Noggin protein Human Noggin (Gln28-Cys232) Accession # Q13253 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus
extended description :
A New and Improved rh Noggin is Now Available! The new protein has ~2 fold better activity, higher purity, and no tag! Earn double rewards for reviews
2020 USD :
329
2021 USD :
329 USD
product details :
A New and Improved rh Noggin is Now Available! The new protein has ~2 fold better activity, higher purity, and no tag! Earn double rewards for reviews
alt names :
NOG, noggin, SYM1, symphalangism 1 (proximal), synostoses (multiple) syndrome 1, SYNS1, SYNS1A
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.