product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Noggin Fc Chimera Protein, CF
catalog :
3344-NG-050
quantity :
50 ug (also 100 ug, 500 ug)
price :
416 USD
more info or order :
R&D Systems product webpage
citations: 24
Reference
Gilmore R, Gorka D, Stoddard C, Cotney J, Chamberlain S. Generation of isogenic models of Angelman syndrome and Prader-Willi syndrome in CRISPR/Cas9-engineered human embryonic stem cells. bioRxiv. 2023;: pubmed publisher
Cohn E, Clayton B, Madhavan M, Yacoub S, Federov Y, Paul Friedman K, et al. Pervasive environmental chemicals impair oligodendrocyte development. bioRxiv. 2023;: pubmed publisher
Wakimizu T, Morikawa K, Fukumura K, Yuki T, Adachi T, Kurata Y, et al. SHOX2 refines the identification of human sinoatrial nodal cell population in the in vitro cardiac differentiation. Regen Ther. 2022;21:239-249 pubmed publisher
Yang D, Gomez Garcia J, Funakoshi S, Tran T, Fernandes I, Bader G, et al. Modeling human multi-lineage heart field development with pluripotent stem cells. Cell Stem Cell. 2022;29:1382-1401.e8 pubmed publisher
Tang Y, Kwiatkowski D, Henske E. Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment. Nat Commun. 2022;13:5018 pubmed publisher
Martin S, Allan K, Pinkard O, Sweet T, Tesar P, Coller J. Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay. Nat Commun. 2022;13:5003 pubmed publisher
Aghazadeh Y, Poon F, Sarangi F, Wong F, Khan S, Sun X, et al. Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models. Cell Stem Cell. 2021;28:1936-1949.e8 pubmed publisher
Allan K, Hu L, Scavuzzo M, Morton A, Gevorgyan A, Cohn E, et al. Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function. Cell Stem Cell. 2021;28:257-272.e11 pubmed publisher
Chung S, Shen W, Davidson K, Pebay A, Wong R, Yau B, et al. Differentiation of Retinal Glial Cells From Human Embryonic Stem Cells by Promoting the Notch Signaling Pathway. Front Cell Neurosci. 2019;13:527 pubmed publisher
Matjusaitis M, Wagstaff L, Martella A, Baranowski B, Blin C, Gogolok S, et al. Reprogramming of Fibroblasts to Oligodendrocyte Progenitor-like Cells Using CRISPR/Cas9-Based Synthetic Transcription Factors. Stem Cell Reports. 2019;13:1053-1067 pubmed publisher
Scerbo P, Marchal L, Kodjabachian L. Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2. elife. 2017;6: pubmed publisher
Kestens C, Siersema P, Offerhaus G, van Baal J. BMP4 Signaling Is Able to Induce an Epithelial-Mesenchymal Transition-Like Phenotype in Barrett's Esophagus and Esophageal Adenocarcinoma through Induction of SNAIL2. PLoS ONE. 2016;11:e0155754 pubmed publisher
Guezguez A, Paré F, Benoit Y, Basora N, Beaulieu J. Modulation of stemness in a human normal intestinal epithelial crypt cell line by activation of the WNT signaling pathway. Exp Cell Res. 2014;322:355-64 pubmed publisher
Prabakar K, Dominguez Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, et al. Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells. Cell Transplant. 2012;21:1321-39 pubmed publisher
Kelly O, Chan M, Martinson L, Kadoya K, Ostertag T, Ross K, et al. Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells. Nat Biotechnol. 2011;29:750-6 pubmed publisher
Kelly M, Hirschi K. Signaling hierarchy regulating human endothelial cell development. Arterioscler Thromb Vasc Biol. 2009;29:718-24 pubmed publisher
Gil J, Woo D, Shim J, Kim S, You H, Park S, et al. Vitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cells. FEBS Lett. 2009;583:561-7 pubmed publisher
Yao Y, Shao E, Jumabay M, Shahbazian A, Ji S, BOSTROM K. High-density lipoproteins affect endothelial BMP-signaling by modulating expression of the activin-like kinase receptor 1 and 2. Arterioscler Thromb Vasc Biol. 2008;28:2266-74 pubmed publisher
Elkabetz Y, Panagiotakos G, Al Shamy G, Socci N, Tabar V, Studer L. Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev. 2008;22:152-65 pubmed publisher
Wen Z, Han L, Bamburg J, Shim S, Ming G, Zheng J. BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin. J Cell Biol. 2007;178:107-19 pubmed publisher
Knobloch J, Shaughnessy J, Ruther U. Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway. FASEB J. 2007;21:1410-21 pubmed
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product information
master code :
3344-NG
SKU :
3344-NG-050
product name :
Recombinant Human Noggin Fc Chimera Protein, CF
unit size :
50 ug (also 100 ug, 500 ug)
description :
The Recombinant Human Noggin Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Noggin Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
Noggin
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
species :
Human
observed molecular weight :
58-62 kDa, reducing conditions
theoretical molecular weight :
49.6 kDa (monomer)
gene symbol :
NOG
details of functionality :
Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.100-0.400 ╡g/mL in the presence of 30 ng/mL of Recombinant Human BMP-4 (Catalog # 314-BP ).
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Graph showing bioactivity of human Noggin protein
accessionNumbers :
Q13253
applications :
Bioactivity
source long :
Mouse myeloma cell line, NS0-derived human Noggin protein Human Noggin (Gln28-Cys232) Accession # Q13253 IEGRMD Human IgG1 (Pro100-Lys330) N-terminus C-terminus
source short :
NS0
USD :
416 USD
alt names :
NOG, noggin, SYM1, symphalangism 1 (proximal), synostoses (multiple) syndrome 1, SYNS1, SYNS1A
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.