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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Mesothelin (aa 296-580) His Protein, CF
catalog :
3265-MS-050
quantity :
50 ug
price :
396 USD
more info or order :
R&D Systems product webpage
citations: 4
Reference
Duran A, Guerrero P, Ortiz M, P xe9 rez Del Campo D, Castro E, Garcia Velasco A, et al. Characterization of Mesothelin Glycosylation in Pancreatic Cancer: Decreased Core Fucosylated Glycoforms in Pancreatic Cancer Patients' Sera. Biomedicines. 2022;10: pubmed publisher
Fierle J, Abram Saliba J, Atsaves V, Brioschi M, de Tiani M, Reichenbach P, et al. A cell-based phenotypic library selection and screening approach for the de novo discovery of novel functional chimeric antigen receptors. Sci Rep. 2022;12:1136 pubmed publisher
Montemagno C, Bacot S, Ahmadi M, Kerfelec B, Baty D, Debiossat M, et al. Preclinical Evaluation of Mesothelin-Specific Ligands for SPECT Imaging of Triple-Negative Breast Cancer. J Nucl Med. 2018;59:1056-1062 pubmed publisher
Yuan J, Kashiwagi S, Reeves P, Nezivar J, Yang Y, Arrifin N, et al. A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma. J Hematol Oncol. 2014;7:15 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
3265-MS
SKU :
3265-MS-050
product name :
Recombinant Human Mesothelin (aa 296-580) His Protein, CF
Description :
The Recombinant Human Mesothelin (aa 296-580) His Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Mesothelin (aa 296-580) His Protein, CF has been validated for the following applications: Bioactivity.
target :
Mesothelin
category :
Proteins and Enzymes
unit size :
50 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
40-45 kDa, reducing conditions
theoretical molecular weight :
33 kDa
gene symbol :
MSLN
details of functionality :
Measured by its binding ability in a functional ELISA. When Recombinant Human CA125/MUC16 (Catalog # 5609-MU ) is coated at 2 µg/mL (100 µL/well), the concentration of Recombinant Human Mesothelin C-Terminal (aa 296-580) His-tag that produces 50% of the optimal binding response is found to be approximately 0.5-2.5 µg/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
AAH09272
applications :
Bioactivity
source :
NS0-derived Recombinant Human Mesothelin (aa 296-580) His Protein
extended description :
C-Terminal
USD :
396 USD
product details :
C-Terminal
alt names :
CAK1, CAK1 antigen, megakaryocyte potentiating factor, mesothelin, MPF, MPFSMRP, MSLN, Pre-pro-megakaryocyte-potentiating factor, SMR, soluble MPF mesothelin related protein
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.